Development Level

Tbio 35 | 10,625
Tchem 8 | 1,890
Tdark 8 | 7,003
Tclin 3 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

embryonic lethality prior to t... 6 | 187
abnormal bone mineralization 5 | 55
embryonic lethality prior to o... 5 | 148
abnormal bone structure 4 | 131
increased heart weight 4 | 37
preweaning lethality, complete... 4 | 633
decreased mean corpuscular vol... 2 | 50
hypoactivity 2 | 89
abnormal kidney morphology 1 | 30
abnormal seminal vesicle morph... 1 | 47
cardiovascular system phenotyp... 1 | 35
decreased B cell number 1 | 30
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased hemoglobin content 1 | 53
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean platelet volume 1 | 12
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased mean corpuscular hem... 1 | 93
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small adrenal glands 1 | 15
small lymph nodes 1 | 1
thrombocytosis 1 | 23

Disease

ovarian cancer 29 | 8,484
osteosarcoma 26 | 7,933
glioblastoma 24 | 5,572
psoriasis 24 | 6,685
medulloblastoma, large-cell 22 | 6,234
atypical teratoid / rhabdoid tumor 20 | 4,369
ependymoma 17 | 2,514
lung cancer 15 | 4,466
oligodendroglioma 15 | 2,849
primitive neuroectodermal tumor 15 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
astrocytic glioma 13 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
lung adenocarcinoma 13 | 2,713
Pick disease 12 | 1,893
lung carcinoma 12 | 2,844
pancreatic cancer 12 | 2,300
pilocytic astrocytoma 12 | 3,086
Cancer 11 | 2,346
Carcinoma 11 | 2,147
adult high grade glioma 11 | 2,148
invasive ductal carcinoma 11 | 2,950
pituitary cancer 11 | 1,972
Breast cancer 10 | 3,094
Multiple myeloma 10 | 1,327
pediatric high grade glioma 10 | 2,712
subependymal giant cell astrocytoma 10 | 2,287
astrocytoma 9 | 1,493
medulloblastoma 9 | 1,524
non-small cell lung cancer 9 | 2,798
dermatomyositis 8 | 933
malignant mesothelioma 8 | 3,162
Kidney disease 7 | 396
colon cancer 7 | 1,475
diabetes mellitus 7 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
primary pancreatic ductal adenocarcinoma 7 | 1,271
sonic hedgehog group medulloblastoma 7 | 1,482
spina bifida 7 | 1,064
Carney complex 6 | 23
esophageal adenocarcinoma 6 | 737
group 3 medulloblastoma 6 | 2,254
group 4 medulloblastoma 6 | 1,875
Adenoma 5 | 165
Beckwith-Wiedemann syndrome 5 | 46
Cushing's syndrome 5 | 47
Down syndrome 5 | 548
Obesity 5 | 616
Osteopetrosis 5 | 40
breast carcinoma 5 | 1,614
cystic fibrosis 5 | 1,665
ductal carcinoma in situ 5 | 1,745
non primary Sjogren syndrome sicca 5 | 840
ulcerative colitis 5 | 2,087
Acrodysostosis 4 | 9
Acromegaly 4 | 40
Alzheimer's disease 4 | 644
Bone cancer 4 | 9
Brachydactyly 4 | 52
Fibrodysplasia ossificans progressiva 4 | 17
Fibrous dysplasia 4 | 15
Hyperphosphatemia 4 | 32
Hyperthyroidism 4 | 50
Hypoparathyroidism 4 | 29
Hypothyroidism 4 | 89
Kidney cancer 4 | 118
McCune Albright syndrome 4 | 19
Multiple Endocrine Neoplasia Type 1 4 | 30
Ossifying fibroma 4 | 13
Pituitary adenoma 4 | 35
Primary pigmented nodular adrenocortical disease 4 | 12
Pseudohypoparathyroidism 4 | 17
Sensorineural hearing loss 4 | 107
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 918
atypical teratoid/rhabdoid tumor 4 | 1,095
cutaneous lupus erythematosus 4 | 1,056
interstitial cystitis 4 | 2,299
tuberculosis 4 | 1,557
Animal Mammary Neoplasms 3 | 136
Cholangiocarcinoma 3 | 32
Craniofacial Abnormalities 3 | 147
Cutis laxa 3 | 28
Epilepsy 3 | 346
Intellectual disability 3 | 573
Mammary Neoplasms, Experimental 3 | 150
Parkinson's disease 3 | 364
Prostatic Neoplasms 3 | 471
active ulcerative colitis 3 | 477
adrenocortical carcinoma 3 | 1,427
aldosterone-producing adenoma 3 | 664
chronic rhinosinusitis 3 | 512
glioblastoma multiforme 3 | 347
hepatocellular carcinoma 3 | 532
mucosa-associated lymphoid tissue lymphoma 3 | 480
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
tuberculosis and treatment for 3 months 3 | 327
tuberculosis and treatment for 6 months 3 | 686

Tissue

Cardiovascular System 53 | 17,958
Digestive Tract 53 | 18,473
Male tissues 53 | 17,969
Urinary Tract 53 | 18,444
Blood and immune system 52 | 17,995
Nervous System 52 | 18,561
Respiratory system 52 | 17,484
Endocrine System 51 | 18,512
Female tissues 51 | 18,647
Liver and Pancreas 51 | 18,136
Skin and soft tissues 50 | 18,115

Target Family

Enzyme 30 | 4,146
Non-IDG 17 | 11,971
Kinase 4 | 634
Ion Channel 2 | 341
Transporter 1 | 473

KEGG Pathway

Vibrio cholerae infection 54 | 54
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
V-type proton ATPase 116 kDa subunit a isoform 1 ATP6V0A1 Tbio Enzyme -1.36455 23.7 59
Protein transport protein Sec61 subunit alpha isoform 1 SEC61A1 Tbio Non-IDG -2.43916 280.2 94
Protein disulfide-isomerase A4 PDIA4 Tbio Enzyme -1.63645 41.6 248
ER lumen protein-retaining receptor 1 KDELR1 Tbio Non-IDG -2.24993 170.8 122
Protein transport protein Sec61 subunit gamma SEC61G Tdark Non-IDG -0.37727 2.21 27
V-type proton ATPase subunit e 2 ATP6V0E2 Tdark Enzyme 0.18 0.40 19
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -0.98803 10.3 111
Cystic fibrosis transmembrane conductance regulator CFTR Tclin Ion Channel -3.74904 5988.4 267