Development Level

Tbio 35 | 11,445
Tchem 9 | 1,598
Tdark 6 | 6,588
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

embryonic lethality prior to t... 6 | 278
preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 5 | 239
abnormal bone structure 4 | 187
increased heart weight 4 | 62
increased startle reflex 4 | 112
decreased hemoglobin content 3 | 68
abnormal behavior 2 | 298
decreased hematocrit 2 | 46
increased or absent threshold ... 2 | 101
abnormal bone mineralization 1 | 38
abnormal digit morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
hyperactivity 1 | 148
hypoactivity 1 | 132
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased erythrocyte cell num... 1 | 39
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 38 | 11,493
ovarian cancer 32 | 8,520
osteosarcoma 26 | 7,950
glioblastoma 25 | 5,792
psoriasis 24 | 6,694
atypical teratoid / rhabdoid tumor 23 | 5,112
ependymoma 23 | 4,679
medulloblastoma, large-cell 22 | 6,241
lung cancer 19 | 4,740
adult high grade glioma 16 | 3,801
astrocytic glioma 16 | 2,597
oligodendroglioma 15 | 2,850
primitive neuroectodermal tumor 15 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
lung adenocarcinoma 13 | 2,716
Astrocytoma, Pilocytic 12 | 3,081
Breast cancer 12 | 3,578
Kidney cancer 12 | 2,613
Pick disease 12 | 1,894
group 3 medulloblastoma 12 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung carcinoma 12 | 2,843
pancreatic cancer 12 | 2,398
invasive ductal carcinoma 11 | 2,951
pituitary cancer 11 | 1,972
Cancer 10 | 2,499
Multiple myeloma 10 | 1,332
subependymal giant cell astrocytoma 10 | 2,287
Autosomal recessive predisposition 9 | 1,442
diabetes mellitus 9 | 1,728
group 4 medulloblastoma 9 | 1,855
non-small cell lung cancer 9 | 2,890
dermatomyositis 8 | 966
malignant mesothelioma 8 | 3,232
Epilepsy 7 | 792
Kidney disease 7 | 430
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primary pancreatic ductal adenocarcinoma 7 | 1,109
spina bifida 7 | 1,074
Carney complex 6 | 25
Failure to gain weight 6 | 365
Pediatric failure to thrive 6 | 365
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
esophageal adenocarcinoma 6 | 737
tuberculosis 6 | 2,010
Beckwith-Wiedemann syndrome 5 | 44
Brachydactyly 5 | 156
Cushing's syndrome 5 | 48
Down syndrome 5 | 499
Obesity 5 | 678
Osteopetrosis 5 | 43
Polycystic ovary syndrome 5 | 360
Primary pigmented nodular adrenocortical disease 5 | 13
Short stature 5 | 531
Small intestine cancer 5 | 12
breast carcinoma 5 | 1,638
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,312
medulloblastoma 5 | 720
non primary Sjogren syndrome sicca 5 | 891
pediatric high grade glioma 5 | 1,064
ulcerative colitis 5 | 1,819
Acrodysostosis 4 | 12
Acromegaly 4 | 51
Adenoma 4 | 167
Adrenal gland cancer 4 | 12
Alzheimer's disease 4 | 658
Biliary tract cancer 4 | 19
Bipolar Disorder 4 | 666
Bone cancer 4 | 16
Cervix carcinoma 4 | 10
Cutis Laxa 4 | 39
DOID:3297 4 | 4
Fibrodysplasia ossificans progressiva 4 | 17
Fibrous dysplasia 4 | 15
Hyperphosphatemia 4 | 32
Hyperthyroidism 4 | 53
Hypoparathyroidism 4 | 41
Hypothyroidism 4 | 122
Liver cancer 4 | 604
McCune Albright syndrome 4 | 19
Multiple Endocrine Neoplasia Type 1 4 | 29
Ossifying fibroma 4 | 15
Osteoporosis 4 | 363
Pituitary adenoma 4 | 38
Plummer's disease 4 | 11
Pseudohypoparathyroidism 4 | 18
Pseudohypoparathyroidism type 1C 4 | 4
Schizophrenia 4 | 1,160
Seizures 4 | 596
Sensorineural hearing loss 4 | 106
Stomach cancer 4 | 30
Substance Withdrawal Syndrome 4 | 55
Thyroid cancer 4 | 36
Waldenstrons macroglobulinemia 4 | 765
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
substance-related disorder 4 | 162

Tissue

Male tissues 50 | 17,142
Blood and immune system 49 | 16,909
Endocrine System 49 | 18,159
Urinary Tract 49 | 16,678
Digestive Tract 48 | 17,369
Female tissues 48 | 17,400
Nervous System 48 | 16,725
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230
Liver and Pancreas 47 | 16,750
Cardiovascular System 46 | 15,192

Target Family

Enzyme 30 | 4,145
Non-IDG 16 | 12,091
Kinase 4 | 634
Ion Channel 2 | 344
Transporter 1 | 473

KEGG Pathway

Vibrio cholerae infection 53 | 53
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.90675 800.2 365
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -1.04091 10.7 137
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.83801 66.4 144
V-type proton ATPase subunit E 2 ATP6V1E2 Tbio Enzyme -0.78312 6.53 60
Protein ALEX GNAS Tbio Non-IDG -2.63356 1389.7 509
V-type proton ATPase subunit F ATP6V1F Tbio Enzyme -0.91914 8.76 118
V-type proton ATPase subunit C 1 ATP6V1C1 Tbio Enzyme -1.31659 21.7 102