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Target Filters...

Development Level

Tbio 40 | 11,651
Tchem 3 | 1,388
Tdark 3 | 6,593
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal bone structure 4 | 187
increased heart weight 4 | 62
increased startle reflex 4 | 112
increased circulating alkaline... 3 | 122
increased circulating total pr... 3 | 28
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to o... 2 | 239
increased circulating creatini... 2 | 38
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lymphocyte cell numb... 1 | 32
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 28 | 11,493
osteosarcoma 24 | 7,950
ovarian cancer 24 | 8,520
psoriasis 24 | 6,694
glioblastoma 19 | 5,792
lung cancer 17 | 4,740
medulloblastoma, large-cell 17 | 6,241
atypical teratoid / rhabdoid tumor 16 | 5,112
ependymoma 16 | 4,679
group 3 medulloblastoma 13 | 4,104
Cancer 12 | 2,499
adult high grade glioma 12 | 3,801
Breast cancer 11 | 3,578
Pick disease 10 | 1,894
Astrocytoma, Pilocytic 9 | 3,081
astrocytic glioma 9 | 2,597
malignant mesothelioma 9 | 3,232
oligodendroglioma 9 | 2,850
pancreatic cancer 9 | 2,398
Kidney cancer 8 | 2,613
Kidney disease 8 | 430
invasive ductal carcinoma 8 | 2,951
primitive neuroectodermal tumor 8 | 3,035
Epilepsy 7 | 792
Polycystic ovary syndrome 7 | 360
diabetes mellitus 7 | 1,728
non-small cell lung cancer 7 | 2,890
subependymal giant cell astrocytoma 7 | 2,287
Carney complex 6 | 25
Cushing's syndrome 6 | 48
Liver cancer 6 | 604
Obesity 6 | 678
Schizophrenia 6 | 1,160
Substance Withdrawal Syndrome 6 | 55
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung carcinoma 6 | 2,843
pituitary cancer 6 | 1,972
Beckwith-Wiedemann syndrome 5 | 44
Bipolar Disorder 5 | 666
Bone cancer 5 | 16
Brachydactyly 5 | 156
Depressive disorder 5 | 409
Dull intelligence 5 | 645
Hypothyroidism 5 | 122
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Pituitary adenoma 5 | 38
Poor school performance 5 | 645
Primary pigmented nodular adrenocortical disease 5 | 13
acute quadriplegic myopathy 5 | 1,158
dermatomyositis 5 | 966
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
juvenile dermatomyositis 5 | 1,187
lung adenocarcinoma 5 | 2,716
progressive supranuclear palsy 5 | 676
Acrodysostosis 4 | 12
Acromegaly 4 | 51
Adenoma 4 | 167
Adrenal gland cancer 4 | 12
Autosomal recessive predisposition 4 | 1,442
Biliary tract cancer 4 | 19
Cardiomyopathies 4 | 110
Cervix carcinoma 4 | 10
Cushing syndrome due to macronodular adrenal hyperplasia 4 | 5
DOID:3297 4 | 4
Duchenne muscular dystrophy 4 | 601
Failure to gain weight 4 | 365
Fibrodysplasia ossificans progressiva 4 | 17
Fibrous dysplasia 4 | 15
Hyperphosphatemia 4 | 32
Hyperthyroidism 4 | 53
Hypoparathyroidism 4 | 41
Inappropriate ADH syndrome 4 | 5
McCune Albright syndrome 4 | 19
Monostotic fibrous dysplasia 4 | 4
Multiple Endocrine Neoplasia Type 1 4 | 29
Ossifying fibroma 4 | 15
Parkinson's disease 4 | 392
Pediatric failure to thrive 4 | 365
Plummer's disease 4 | 11
Progressive osseous heteroplasia 4 | 4
Pseudohypoparathyroidism 4 | 18
Pseudohypoparathyroidism type 1C 4 | 4
Pseudohypoparathyroidism, Type 1B 4 | 5
Pseudopseudohypoparathyroidism 4 | 6
Seizures 4 | 596
Short stature 4 | 531
Small intestine cancer 4 | 12
Stomach cancer 4 | 30
Thyroid cancer 4 | 36
Waldenstrons macroglobulinemia 4 | 765
aldosterone-producing adenoma 4 | 665
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
cutaneous lupus erythematosus 4 | 1,057
pediatric high grade glioma 4 | 1,064
substance-related disorder 4 | 162

Tissue

Endocrine System 44 | 18,159
Urinary Tract 43 | 16,678
Blood and immune system 42 | 16,909
Digestive Tract 42 | 17,369
Liver and Pancreas 42 | 16,750
Male tissues 42 | 17,142
Skin and soft tissues 42 | 17,230
Female tissues 41 | 17,400
Nervous System 41 | 16,725
Cardiovascular System 40 | 15,192
Respiratory system 40 | 16,393

Target Family

Non-IDG 27 | 12,091
Enzyme 9 | 4,145
Transcription Factor 7 | 1,400
Kinase 3 | 634
GPCR 1 | 408

KEGG Pathway

Vasopressin-regulated water re... 47 | 47
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Cyclic AMP-responsive element-binding protein 5 CREB5 Tbio Transcription Factor -0.88055 7.80 164
Dynactin subunit 4 DCTN4 Tbio Non-IDG -0.85019 7.19 160
Dynactin subunit 5 DCTN5 Tdark Non-IDG -0.32495 0.71 53
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Vasopressin-neurophysin 2-copeptin AVP Tbio Non-IDG -3.92570 8381.2 203
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS Tbio Non-IDG -2.63356 1389.7 509
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.77874 581.3 185
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.20325 12.9 155