Development Level

Tbio 41 | 11,445
Tchem 4 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased circulating alkaline... 2 | 46
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased body length 1 | 32
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 37 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
ovarian cancer 27 | 8,520
Autosomal recessive predisposition 25 | 1,442
psoriasis 20 | 6,694
Muscle hypotonia 19 | 571
osteosarcoma 19 | 7,950
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
Epilepsy 16 | 792
Seizures 16 | 596
interstitial cystitis 16 | 2,312
lung cancer 16 | 4,740
medulloblastoma, large-cell 16 | 6,241
atypical teratoid / rhabdoid tumor 15 | 5,112
glioblastoma 15 | 5,792
Hypoglycemia 14 | 152
ependymoma 14 | 4,679
ulcerative colitis 14 | 1,819
Lethargy 12 | 77
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
invasive ductal carcinoma 12 | 2,951
Dull intelligence 11 | 645
Intellectual disability 11 | 1,016
Low intelligence 11 | 645
Maple syrup urine disease 11 | 24
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Metabolic acidosis 11 | 90
Poor school performance 11 | 645
adult high grade glioma 11 | 3,801
malignant mesothelioma 11 | 3,232
Vomiting 10 | 116
colon cancer 10 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
lung adenocarcinoma 10 | 2,716
lung carcinoma 10 | 2,843
Acidosis, Lactic 9 | 97
Comatose 9 | 56
Lactic acidemia 9 | 95
Pick disease 9 | 1,894
non-small cell lung cancer 9 | 2,890
oligodendroglioma 9 | 2,850
Breast cancer 8 | 3,578
Multiple myeloma 8 | 1,332
adrenocortical carcinoma 8 | 1,428
beta-ketothiolase deficiency 8 | 13
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Dystonia 7 | 164
Dystonic disease 7 | 106
Failure to gain weight 7 | 365
Feeding difficulties in infancy 7 | 175
Hepatomegaly 7 | 285
Methylmalonic acidemia 7 | 37
Pediatric failure to thrive 7 | 365
Succinic semialdehyde dehydrogenase deficiency 7 | 16
astrocytic glioma 7 | 2,597
cystic fibrosis 7 | 1,696
group 3 medulloblastoma 7 | 4,104
tuberculosis 7 | 2,010
3-Methylcrotonyl-CoA carboxylase deficiency 6 | 11
Astrocytoma, Pilocytic 6 | 3,081
Hyperammonemia 6 | 30
Medium chain acyl-CoA dehydrogenase deficiency 6 | 13
Pancreatitis 6 | 123
Propionic acidemia 6 | 16
Waldenstrons macroglobulinemia 6 | 765
breast carcinoma 6 | 1,638
gastric carcinoma 6 | 807
pancreatic cancer 6 | 2,398
primitive neuroectodermal tumor 6 | 3,035
Cardiomyopathies 5 | 110
Cerebellar Ataxia 5 | 304
Dehydration 5 | 40
Kidney cancer 5 | 2,613
Liver Cirrhosis, Experimental 5 | 769
Obesity 5 | 678
Very long chain acyl-CoA dehydrogenase deficiency 5 | 10
acute myeloid leukemia 5 | 783
astrocytoma 5 | 1,146
nephrosclerosis 5 | 333
3-methylglutaconic aciduria 4 | 29
Atopic dermatitis 4 | 952
Cardiomyopathy, Dilated 4 | 83
Delayed speech and language development 4 | 112
Dysarthria 4 | 192
Feeding difficulties 4 | 127
Infantile onset 4 | 238
Isovaleric acidemia 4 | 15
Language Delay 4 | 112
Osteoarthritis 4 | 184
Osteoporosis 4 | 363
Short stature 4 | 531
Speech Delay 4 | 112
Speech impairment 4 | 112
Thrombocytopenia 4 | 197
active Crohn's disease 4 | 922
aldosterone-producing adenoma 4 | 665

Tissue

Digestive Tract 48 | 17,369
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Nervous System 48 | 16,725
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Blood and immune system 47 | 16,909
Cardiovascular System 47 | 15,192
Endocrine System 47 | 18,159
Male tissues 47 | 17,142
Respiratory system 47 | 16,393

Target Family

Enzyme 46 | 4,145
Non-IDG 2 | 12,091

KEGG Pathway

Valine, leucine and isoleucine... 48 | 48
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 Tbio Enzyme -1.91194 82.4 102
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.79074 622.3 53
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.9 150
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Acetoacetyl-CoA synthetase AACS Tbio Enzyme -2.09428 127.1 97
Methylmalonyl-CoA epimerase, mitochondrial MCEE Tbio Enzyme -1.05059 11.7 115
4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 Tbio Enzyme -1.43954 27.0 162
Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 Tbio Enzyme -1.47858 32.0 77