Development Level

Tbio 120 | 11,445
Tchem 11 | 1,598
Tdark 5 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 13 | 979
decreased bone mineral content 8 | 151
preweaning lethality, incomple... 8 | 499
abnormal bone structure 6 | 187
decreased bone mineral density 6 | 126
abnormal behavior 5 | 298
decreased lean body mass 4 | 135
embryonic lethality prior to o... 4 | 239
increased mean corpuscular vol... 4 | 92
male infertility 4 | 123
abnormal embryo size 3 | 220
abnormal retina morphology 3 | 71
decreased body length 3 | 101
decreased body weight 3 | 161
decreased startle reflex 3 | 75
embryonic lethality prior to t... 3 | 278
increased lymphocyte cell numb... 3 | 32
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
short tibia 3 | 97
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
corneal opacity 2 | 32
decreased circulating chloride... 2 | 30
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased heart left ventricle... 2 | 28
decreased lymphocyte cell numb... 2 | 83
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
female infertility 2 | 60
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased heart weight 2 | 62
narrow eye opening 2 | 12
tremors 2 | 39
trunk curl 2 | 16
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal esophagus morphology 1 | 5
abnormal eyelid morphology 1 | 7
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal placenta size 1 | 20
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
brachydactyly 1 | 19
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating creatini... 1 | 39
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased fluid intake 1 | 3
decreased food intake 1 | 13
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
syndactyly 1 | 23
thin ventricular wall 1 | 24

Disease

ovarian cancer 99 | 8,520
Carcinoma 88 | 11,493
osteosarcoma 72 | 7,950
medulloblastoma, large-cell 51 | 6,241
psoriasis 50 | 6,694
lung cancer 49 | 4,740
atypical teratoid / rhabdoid tumor 48 | 5,112
glioblastoma 48 | 5,792
Cancer 42 | 2,499
Breast cancer 33 | 3,578
ependymoma 30 | 4,679
Kidney cancer 29 | 2,613
Multiple myeloma 29 | 1,332
adult high grade glioma 29 | 3,801
group 3 medulloblastoma 29 | 4,104
astrocytic glioma 27 | 2,597
primitive neuroectodermal tumor 26 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
malignant mesothelioma 23 | 3,232
oligodendroglioma 22 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
non-small cell lung cancer 20 | 2,890
subependymal giant cell astrocytoma 20 | 2,287
acute quadriplegic myopathy 19 | 1,158
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Pick disease 18 | 1,894
pancreatic cancer 18 | 2,398
Astrocytoma, Pilocytic 17 | 3,081
juvenile dermatomyositis 17 | 1,187
Rheumatoid arthritis 16 | 1,191
invasive ductal carcinoma 16 | 2,951
Intellectual disability 12 | 1,016
adrenocortical carcinoma 12 | 1,428
dermatomyositis 12 | 966
diabetes mellitus 12 | 1,728
group 4 medulloblastoma 12 | 1,855
spina bifida 12 | 1,074
Autosomal recessive predisposition 11 | 1,442
active Crohn's disease 11 | 922
breast carcinoma 11 | 1,638
esophageal adenocarcinoma 11 | 737
medulloblastoma 11 | 720
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
pituitary cancer 11 | 1,972
tuberculosis 11 | 2,010
acute myeloid leukemia 10 | 783
astrocytoma 10 | 1,146
lung adenocarcinoma 10 | 2,716
lung carcinoma 10 | 2,843
tuberculosis and treatment for 6 months 10 | 409
ulcerative colitis 10 | 1,819
interstitial cystitis 9 | 2,312
non primary Sjogren syndrome sicca 9 | 891
pediatric high grade glioma 9 | 1,064
Dull intelligence 8 | 645
Liver cancer 8 | 604
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Waldenstrons macroglobulinemia 8 | 765
primary pancreatic ductal adenocarcinoma 8 | 1,109
Amyotrophic lateral sclerosis 7 | 451
Breast Neoplasms 7 | 445
Congenital hypoplasia of penis 7 | 176
Cryptorchidism 7 | 296
Mammary Neoplasms 7 | 425
Atopic dermatitis 6 | 952
Liddle syndrome 6 | 14
Muscle hypotonia 6 | 571
Parkinson's disease 6 | 392
Short stature 6 | 531
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
hepatocellular carcinoma 6 | 547
Acquired scoliosis 5 | 281
Anemia 5 | 365
Autistic Disorder 5 | 364
Carcinoma, Renal Cell 5 | 124
Cockayne syndrome 5 | 60
Cognitive delay 5 | 608
Curvature of spine 5 | 282
Epilepsy 5 | 792
Global developmental delay 5 | 608
Hypertensive disease 5 | 292
Melanoma 5 | 711
Mental and motor retardation 5 | 608
Multiple Sclerosis 5 | 540
Obesity 5 | 678
Penile hypospadias 5 | 106
Renal Cell Carcinoma 5 | 214
Short neck 5 | 140
Stevens-Johnson syndrome 5 | 92
Strabismus 5 | 270
X- linked recessive 5 | 110
ductal carcinoma in situ 5 | 1,745
primary Sjogren syndrome 5 | 735
sonic hedgehog group medulloblastoma 5 | 467
Schizophrenia 4 | 1,160

Tissue

Blood and immune system 135 | 16,909
Digestive Tract 135 | 17,369
Endocrine System 135 | 18,159
Female tissues 135 | 17,400
Male tissues 135 | 17,142
Nervous System 134 | 16,725
Urinary Tract 134 | 16,678
Cardiovascular System 133 | 15,192
Liver and Pancreas 133 | 16,750
Respiratory system 133 | 16,393
Skin and soft tissues 133 | 17,230

Target Family

Non-IDG 84 | 12,091
Enzyme 47 | 4,145
Transcription Factor 4 | 1,400
Kinase 1 | 634
TF/Epigenetic 1 | 38

KEGG Pathway

Ubiquitin mediated proteolysis 137 | 137
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Cullin-7 CUL7 Tbio Non-IDG -1.49747 38.0 139
Anaphase-promoting complex subunit 7 ANAPC7 Tbio Enzyme -0.17118 1.40 73
F-box only protein 2 FBXO2 Tbio Non-IDG -1.36281 26.8 157
E3 ubiquitin-protein ligase FANCL FANCL Tbio Enzyme -2.46302 286.2 146
RING finger protein 37 UBOX5 Tbio Non-IDG -0.03779 0.72 104
E3 ubiquitin-protein ligase TRIM37 TRIM37 Tbio Enzyme -3.25892 1754.8 177
Anaphase-promoting complex subunit 11 ANAPC11 Tbio Enzyme -1.27406 17.9 239