Development Level

Tbio 115 | 11,651
Tchem 51 | 1,388
Tclin 18 | 612
Tdark 5 | 6,593

IMPC Phenotype

preweaning lethality, complete... 10 | 979
decreased lymphocyte cell numb... 5 | 83
decreased mean corpuscular hem... 4 | 50
decreased mean corpuscular vol... 4 | 79
embryonic lethality prior to t... 4 | 278
increased circulating alkaline... 4 | 122
increased neutrophil cell numb... 4 | 46
preweaning lethality, incomple... 4 | 499
short tibia 4 | 97
abnormal bone structure 3 | 187
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased grip strength 3 | 116
embryonic lethality prior to o... 3 | 239
increased erythrocyte cell num... 3 | 39
increased leukocyte cell numbe... 3 | 47
abnormal behavior 2 | 298
abnormal femur morphology 2 | 14
abnormal seminal vesicle morph... 2 | 114
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased circulating fructosa... 2 | 13
increased circulating sodium l... 2 | 71
increased eosinophil cell numb... 2 | 11
increased lymphocyte cell numb... 2 | 32
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
small superior vagus ganglion 2 | 74
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal sensory capabilities-... 1 | 8
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged cecum 1 | 5
enlarged uterus 1 | 11
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased basophil cell number 1 | 7
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased circulating thyroxin... 1 | 7
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
mammalian phenotype 1 | 17
premature death 1 | 5
small heart 1 | 10
small kidney 1 | 16
small spleen 1 | 19
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 95 | 11,493
ovarian cancer 92 | 8,520
Cancer 89 | 2,499
psoriasis 85 | 6,694
osteosarcoma 82 | 7,950
glioblastoma 78 | 5,792
lung cancer 68 | 4,740
tuberculosis 59 | 2,010
lung carcinoma 58 | 2,843
medulloblastoma, large-cell 56 | 6,241
diabetes mellitus 55 | 1,728
Astrocytoma, Pilocytic 51 | 3,081
Rheumatoid arthritis 51 | 1,191
adult high grade glioma 51 | 3,801
ulcerative colitis 46 | 1,819
ependymoma 45 | 4,679
malignant mesothelioma 44 | 3,232
invasive ductal carcinoma 43 | 2,951
subependymal giant cell astrocytoma 43 | 2,287
Schizophrenia 42 | 1,160
atypical teratoid / rhabdoid tumor 40 | 5,112
Multiple Sclerosis 39 | 540
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
Arthritis 36 | 290
Breast cancer 35 | 3,578
interstitial cystitis 35 | 2,312
group 3 medulloblastoma 33 | 4,104
Hypersensitivity reaction type II disease 32 | 253
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
Asthma 31 | 385
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
Kidney disease 29 | 430
non-small cell lung cancer 28 | 2,890
pancreatic cancer 28 | 2,398
Inflammatory bowel disease 27 | 151
Multiple myeloma 27 | 1,332
Systemic lupus erythematosus 27 | 194
sarcoidosis 27 | 370
Autosomal recessive predisposition 26 | 1,442
Alzheimer's disease 24 | 658
Bipolar Disorder 24 | 666
cutaneous lupus erythematosus 24 | 1,057
primary Sjogren syndrome 24 | 735
Liver disease 23 | 237
Vascular disease 23 | 319
cystic fibrosis 23 | 1,696
primitive neuroectodermal tumor 23 | 3,035
Kidney cancer 22 | 2,613
Liver Cirrhosis, Experimental 22 | 769
Obesity 22 | 678
astrocytic glioma 22 | 2,597
breast carcinoma 22 | 1,638
adrenocortical carcinoma 21 | 1,428
astrocytoma 21 | 1,146
mucosa-associated lymphoid tissue lymphoma 21 | 484
periodontitis 21 | 293
Anemia 20 | 365
lung adenocarcinoma 20 | 2,716
oligodendroglioma 20 | 2,850
Brain Ischemia 19 | 110
Crohn's disease 19 | 321
Heart disease 19 | 306
Lung disease 19 | 142
Prostatic Neoplasms 19 | 495
Vasculitis 19 | 80
dermatomyositis 19 | 966
juvenile dermatomyositis 19 | 1,187
Berylliosis 18 | 28
Breast Neoplasms 18 | 445
Mammary Neoplasms 18 | 425
Waldenstrons macroglobulinemia 18 | 765
Arthritis, Rheumatoid 17 | 174
Fever 17 | 138
Hypertension 17 | 396
Narcolepsy 17 | 72
Pneumonia 17 | 174
colon cancer 17 | 1,478
esophageal adenocarcinoma 17 | 737
group 4 medulloblastoma 17 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Atherosclerosis 16 | 291
Depressive disorder 16 | 409
Dermatitis 16 | 157
Epilepsy 16 | 792
Hepatitis B 16 | 108
Lung Neoplasms 16 | 232
Malaria 16 | 160
Reperfusion Injury 16 | 86
active Crohn's disease 16 | 922
active ulcerative colitis 16 | 764
Coronary artery disease 15 | 268
Influenza 15 | 142
Seizures 15 | 596
Stomach Neoplasms 15 | 300
Thrombocytopenia 15 | 197
pituitary cancer 15 | 1,972
Allergic hypersensitivity disease 14 | 126
Inflammation 14 | 120
Mental Depression 14 | 333
Toxic encephalopathy 14 | 141

Tissue

Blood and immune system 162 | 16,909
Endocrine System 159 | 18,159
Male tissues 159 | 17,142
Skin and soft tissues 159 | 17,230
Digestive Tract 158 | 17,369
Female tissues 158 | 17,400
Liver and Pancreas 158 | 16,750
Respiratory system 157 | 16,393
Urinary Tract 157 | 16,678
Nervous System 154 | 16,725
Cardiovascular System 149 | 15,192

Target Family

Non-IDG 117 | 12,091
Kinase 30 | 634
Enzyme 29 | 4,145
Transcription Factor 10 | 1,400
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

KEGG Pathway

Tuberculosis 189 | 189
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Interferon gamma receptor 1 IFNGR1 Tbio Non-IDG -2.23009 172.7 518
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
Interleukin-10 receptor subunit alpha IL10RA Tbio Non-IDG -2.08222 94.9 599
CCAAT/enhancer-binding protein gamma CEBPG Tbio Transcription Factor -0.92558 8.45 248
BH3-interacting domain death agonist BID Tbio Non-IDG -1.85313 58.9 981
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.46402 298.9 76