Development Level

Tbio 49 | 11,445
Tchem 14 | 1,598
Tclin 12 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

abnormal bone structure 5 | 187
decreased total body fat amoun... 4 | 207
increased heart weight 4 | 62
increased startle reflex 4 | 112
decreased circulating insulin ... 3 | 76
embryonic lethality prior to t... 3 | 278
increased lean body mass 3 | 172
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
decreased bone mineral density 2 | 126
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
hyperactivity 2 | 148
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
prenatal lethality prior to he... 2 | 87
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal radius morphology 1 | 8
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal thoracic cage shape 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
abnormal vocalization 1 | 21
abnormal zygomatic bone morpho... 1 | 3
absent optic nerve 1 | 2
absent pinna reflex 1 | 23
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating thyroxin... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased urine creatinine lev... 1 | 3
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
male infertility 1 | 123
prolonged QRS complex duration 1 | 8
small epididymis 1 | 3
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 58 | 11,493
ovarian cancer 39 | 8,520
psoriasis 39 | 6,694
glioblastoma 33 | 5,792
osteosarcoma 33 | 7,950
atypical teratoid / rhabdoid tumor 31 | 5,112
lung cancer 30 | 4,740
medulloblastoma, large-cell 30 | 6,241
Kidney cancer 25 | 2,613
adult high grade glioma 24 | 3,801
group 3 medulloblastoma 24 | 4,104
ependymoma 23 | 4,679
Cancer 22 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
primitive neuroectodermal tumor 22 | 3,035
Astrocytoma, Pilocytic 21 | 3,081
Breast cancer 20 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
lung adenocarcinoma 19 | 2,716
lung carcinoma 18 | 2,843
pancreatic cancer 18 | 2,398
Autosomal recessive predisposition 17 | 1,442
Hypothyroidism 17 | 122
diabetes mellitus 17 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
non-small cell lung cancer 16 | 2,890
invasive ductal carcinoma 15 | 2,951
subependymal giant cell astrocytoma 15 | 2,287
Bipolar Disorder 14 | 666
oligodendroglioma 14 | 2,850
pituitary cancer 14 | 1,972
Hyperthyroidism 13 | 53
Liver cancer 13 | 604
Obesity 13 | 678
ulcerative colitis 13 | 1,819
Depressive disorder 12 | 409
Epilepsy 12 | 792
Intellectual disability 12 | 1,016
Pick disease 12 | 1,894
astrocytic glioma 12 | 2,597
Dull intelligence 11 | 645
Fatigue 11 | 182
Goiter 11 | 38
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
astrocytoma 11 | 1,146
interstitial cystitis 11 | 2,312
Adenoma 10 | 167
Cognitive delay 10 | 608
Congenital hypothyroidism 10 | 26
Global developmental delay 10 | 608
Hypertension 10 | 396
Kidney disease 10 | 430
Melanoma 10 | 711
Mental and motor retardation 10 | 608
Muscle hypotonia 10 | 571
Schizophrenia 10 | 1,160
colon cancer 10 | 1,478
group 4 medulloblastoma 10 | 1,855
tuberculosis 10 | 2,010
Coarse facial features 9 | 108
Constipation 9 | 181
Dyschezia 9 | 135
Short stature 9 | 531
Skin cancer 9 | 469
Thickened facial skin with coarse facial features 9 | 108
juvenile dermatomyositis 9 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Abdomen distended 8 | 43
Atrial Fibrillation 8 | 124
Chronic heart failure 8 | 46
Congestive heart failure 8 | 113
Hypertensive disease 8 | 292
Icterus 8 | 82
Large bregma sutures 8 | 46
Large fontanelle 8 | 46
Large, late-closing fontanelle 8 | 46
Macroglossia 8 | 65
Mental Depression 8 | 333
Poisoning by digitalis glycoside 8 | 8
Prostatic Neoplasms 8 | 495
Rheumatoid arthritis 8 | 1,191
Thyrotoxicosis 8 | 38
Umbilical hernia 8 | 93
Wide bregma sutures 8 | 46
breast carcinoma 8 | 1,638
malignant mesothelioma 8 | 3,232
Duchenne muscular dystrophy 7 | 601
Hypersomnia 7 | 8
Muscle Weakness 7 | 170
Substance Withdrawal Syndrome 7 | 55
Thyroid cancer 7 | 36
cystic fibrosis 7 | 1,696
ductal carcinoma in situ 7 | 1,745
Alzheimer's disease 6 | 658
Multiple myeloma 6 | 1,332
cutaneous lupus erythematosus 6 | 1,057
esophageal adenocarcinoma 6 | 737

Tissue

Endocrine System 73 | 18,159
Digestive Tract 71 | 17,369
Liver and Pancreas 71 | 16,750
Male tissues 71 | 17,142
Skin and soft tissues 70 | 17,230
Female tissues 69 | 17,400
Nervous System 69 | 16,725
Urinary Tract 69 | 16,678
Blood and immune system 68 | 16,909
Respiratory system 65 | 16,393
Cardiovascular System 63 | 15,192

Target Family

Enzyme 27 | 4,145
Non-IDG 18 | 12,091
Transcription Factor 12 | 1,400
Transporter 10 | 473
Kinase 6 | 634
Ion Channel 3 | 344
GPCR 1 | 408

KEGG Pathway

Thyroid hormone synthesis 77 | 77
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Sodium/potassium-transporting ATPase subunit gamma FXYD2 Tclin Enzyme -1.58017 39.0 64
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
Serum albumin ALB Tchem Non-IDG -5.01233 98804.9 2101
Transcription termination factor 2 TTF2 Tbio Non-IDG -0.36173 2.95 140
Pendrin SLC26A4 Tbio Transporter -2.69164 501.3 100
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Adenylate cyclase type 6 ADCY6 Tchem Enzyme -2.05332 113.7 111