Development Level

Tchem 49 | 1,890
Tbio 42 | 10,625
Tclin 26 | 602
Tdark 1 | 7,003

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

decreased circulating choleste... 5 | 85
preweaning lethality, complete... 5 | 633
abnormal behavior 4 | 226
abnormal bone mineralization 4 | 55
decreased body weight 4 | 174
decreased circulating LDL chol... 3 | 37
decreased circulating creatini... 3 | 31
decreased circulating triglyce... 3 | 83
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
increased circulating alkaline... 3 | 119
increased mean corpuscular hem... 3 | 93
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased grip strength 2 | 123
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
increased circulating LDL chol... 2 | 15
increased circulating choleste... 2 | 53
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal placenta size 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal sensory capabilities-... 1 | 3
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent heartbeat 1 | 6
cataract 1 | 26
decreased B cell number 1 | 30
decreased Ly6C low monocyte nu... 1 | 23
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased fasted circulating g... 1 | 49
decreased hemoglobin content 1 | 53
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
decreased thermal nociceptive ... 1 | 4
decreased threshold for audito... 1 | 32
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
enlarged kidney 1 | 7
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hypoactivity 1 | 89
improved glucose tolerance 1 | 56
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating amylase ... 1 | 13
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular vol... 1 | 91
increased plasma cell number 1 | 5
male infertility 1 | 62
pale liver 1 | 5
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
straub tail 1 | 26
thick ventricular wall 1 | 7
thin ventricular wall 1 | 5
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 73 | 8,491
osteosarcoma 66 | 7,933
psoriasis 62 | 6,685
Cancer 60 | 2,346
medulloblastoma, large-cell 52 | 6,234
glioblastoma 47 | 5,572
Carcinoma 43 | 2,147
lung cancer 43 | 4,473
atypical teratoid / rhabdoid tumor 36 | 4,369
primitive neuroectodermal tumor 34 | 3,031
Breast cancer 33 | 3,098
astrocytoma 30 | 1,493
malignant mesothelioma 30 | 3,163
subependymal giant cell astrocytoma 29 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
oligodendroglioma 27 | 2,849
Mammary Neoplasms 26 | 410
ependymoma 26 | 2,514
invasive ductal carcinoma 26 | 2,950
lung adenocarcinoma 26 | 2,714
lung carcinoma 26 | 2,844
pilocytic astrocytoma 26 | 3,086
Prostatic Neoplasms 23 | 471
interstitial cystitis 23 | 2,299
pediatric high grade glioma 21 | 2,712
ulcerative colitis 21 | 2,087
Pick disease 20 | 1,893
colon cancer 19 | 1,475
group 3 medulloblastoma 19 | 2,254
group 4 medulloblastoma 19 | 1,875
non-small cell lung cancer 19 | 2,798
Intellectual disability 18 | 573
Rheumatoid Arthritis 18 | 1,170
Vascular disease 18 | 281
adult high grade glioma 18 | 2,148
diabetes mellitus 18 | 1,663
pancreatic cancer 18 | 2,300
Multiple myeloma 17 | 1,327
adrenocortical carcinoma 17 | 1,427
astrocytic glioma 17 | 2,241
medulloblastoma 17 | 1,524
pituitary cancer 17 | 1,972
Endometriosis 16 | 535
ductal carcinoma in situ 16 | 1,745
Lung Neoplasms 15 | 171
cystic fibrosis 15 | 1,670
juvenile dermatomyositis 15 | 1,189
acute quadriplegic myopathy 14 | 1,157
dermatomyositis 14 | 966
tuberculosis 14 | 1,563
Liver carcinoma 13 | 217
Obesity 13 | 616
Schizophrenia 13 | 503
atypical teratoid/rhabdoid tumor 13 | 1,095
breast carcinoma 13 | 1,614
non-small cell lung carcinoma 13 | 413
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
Alzheimer's disease 12 | 644
Heart disease 12 | 279
Squamous cell carcinoma 12 | 96
Adenoma 11 | 165
Colorectal Neoplasms 11 | 217
Stomach Neoplasms 11 | 282
nasopharyngeal carcinoma 11 | 1,056
Cardiomegaly 10 | 66
Parkinson's disease 10 | 364
Squamous cell carcinoma of esophagus 10 | 82
posterior fossa group A ependymoma 10 | 1,511
sonic hedgehog group medulloblastoma 10 | 1,482
spina bifida 10 | 1,064
Atrial Fibrillation 9 | 110
Bladder Neoplasm 9 | 109
Colonic Neoplasms 9 | 126
Congestive heart failure 9 | 36
Kidney cancer 9 | 121
Kidney disease 9 | 397
Melanoma 9 | 261
Neoplastic Cell Transformation 9 | 81
Osteoporosis 9 | 259
ovarian neoplasm 9 | 97
Adenocarcinoma 8 | 115
Adenoid Cystic Carcinoma 8 | 99
Chronic heart failure 8 | 46
Epilepsy 8 | 346
Hypothyroidism 8 | 89
Poisoning by digitalis glycoside 8 | 8
Waldenstrons macroglobulinemia 8 | 764
acute myeloid leukemia 8 | 785
primary pancreatic ductal adenocarcinoma 8 | 1,271
Crohn's disease 7 | 304
Down syndrome 7 | 548
Hypertension 7 | 293
Hypertensive disease 7 | 193
chronic lymphocytic leukemia 7 | 244
cutaneous lupus erythematosus 7 | 1,056
fibroadenoma 7 | 557
gastric carcinoma 7 | 832
pancreatic carcinoma 7 | 567

Tissue

Blood and immune system 118 | 17,994
Cardiovascular System 118 | 17,957
Digestive Tract 118 | 18,472
Endocrine System 118 | 18,511
Female tissues 118 | 18,646
Liver and Pancreas 118 | 18,135
Male tissues 118 | 17,968
Nervous System 118 | 18,560
Skin and soft tissues 118 | 18,114
Urinary Tract 118 | 18,443
Respiratory system 116 | 17,483

Target Family

Enzyme 36 | 4,146
Kinase 25 | 634
Non-IDG 21 | 11,969
Transporter 14 | 473
Epigenetic 9 | 242
Transcription Factor 7 | 1,400
Nuclear Receptor 6 | 48

KEGG Pathway

Thyroid hormone signaling path... 118 | 118
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.85874 681.4 264
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 Tclin Transporter -1.08214 10.9 189
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.89468 62.9 159
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.86049 63.7 252
Retinoic acid receptor RXR-beta RXRB Tclin Nuclear Receptor -1.71802 49.7 235
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.39396 233.2 634
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.12987 136.7 95
Sodium/potassium-transporting ATPase subunit beta-2 ATP1B2 Tclin Transporter -1.33849 19.3 155