Development Level

Tbio 48 | 11,651
Tchem 40 | 1,388
Tclin 27 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 11 | 979
increased lean body mass 5 | 172
abnormal behavior 4 | 298
abnormal bone mineralization 4 | 38
abnormal gait 4 | 69
decreased body weight 4 | 161
decreased circulating choleste... 4 | 93
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
decreased circulating LDL chol... 3 | 38
decreased circulating creatini... 3 | 39
decreased mean corpuscular vol... 3 | 79
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
hyperactivity 3 | 148
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating choleste... 3 | 66
increased mean corpuscular hem... 3 | 96
increased total body fat amoun... 3 | 134
abnormal embryo size 2 | 220
abnormal lens morphology 2 | 81
abnormal placenta size 2 | 20
cataract 2 | 92
decreased circulating alkaline... 2 | 46
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased mean platelet volume 2 | 25
decreased prepulse inhibition 2 | 82
enlarged heart 2 | 210
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased hemoglobin content 2 | 45
increased lymphocyte cell numb... 2 | 32
pale yolk sac 2 | 25
pallor 2 | 34
prolonged PR interval 2 | 15
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating creatine... 1 | 4
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hypoactivity 1 | 132
impaired righting response 1 | 26
increased T cell number 1 | 6
increased circulating amylase ... 1 | 25
increased circulating creatine... 1 | 5
increased circulating glucose ... 1 | 24
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
pale liver 1 | 6
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 93 | 11,493
ovarian cancer 72 | 8,520
osteosarcoma 64 | 7,950
psoriasis 62 | 6,694
Cancer 60 | 2,499
glioblastoma 54 | 5,792
medulloblastoma, large-cell 52 | 6,241
lung cancer 47 | 4,740
atypical teratoid / rhabdoid tumor 45 | 5,112
Breast cancer 42 | 3,578
Kidney cancer 42 | 2,613
ependymoma 41 | 4,679
group 3 medulloblastoma 37 | 4,104
primitive neuroectodermal tumor 34 | 3,035
malignant mesothelioma 33 | 3,232
Breast Neoplasms 28 | 445
Mammary Neoplasms 28 | 425
adult high grade glioma 28 | 3,801
Schizophrenia 27 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
oligodendroglioma 27 | 2,850
subependymal giant cell astrocytoma 27 | 2,287
lung adenocarcinoma 26 | 2,716
Epilepsy 25 | 792
astrocytic glioma 25 | 2,597
Intellectual disability 24 | 1,016
invasive ductal carcinoma 24 | 2,951
lung carcinoma 24 | 2,843
Astrocytoma, Pilocytic 23 | 3,081
Prostatic Neoplasms 23 | 495
astrocytoma 23 | 1,146
Seizures 22 | 596
interstitial cystitis 21 | 2,312
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
Pick disease 20 | 1,894
Short stature 20 | 531
Autosomal recessive predisposition 19 | 1,442
Carcinoma, Squamous Cell 19 | 110
Rheumatoid arthritis 19 | 1,191
breast carcinoma 19 | 1,638
colon cancer 19 | 1,478
diabetes mellitus 19 | 1,728
non-small cell lung cancer 19 | 2,890
pancreatic cancer 19 | 2,398
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
Vascular disease 18 | 319
group 4 medulloblastoma 18 | 1,855
Bipolar Disorder 17 | 666
Endometriosis 17 | 540
Melanoma 17 | 711
Muscle hypotonia 17 | 571
Orbital separation excessive 17 | 244
adrenocortical carcinoma 17 | 1,428
pituitary cancer 17 | 1,972
Stomach Neoplasms 16 | 300
ductal carcinoma in situ 16 | 1,745
tuberculosis 16 | 2,010
ulcerative colitis 16 | 1,819
Acquired scoliosis 15 | 281
Byzanthine arch palate 15 | 194
Cryptorchidism 15 | 296
Curvature of spine 15 | 282
Downward slant of palpebral fissure 15 | 158
Hypoplastic mandible condyle 15 | 275
Liver cancer 15 | 604
Lung Neoplasms 15 | 232
Mandibular hypoplasia 15 | 275
Micrognathism 15 | 275
Multiple myeloma 15 | 1,332
Squamous cell carcinoma 15 | 129
cystic fibrosis 15 | 1,696
juvenile dermatomyositis 15 | 1,187
Blepharoptosis 14 | 231
Endometrial cancer 14 | 311
Obesity 14 | 678
acute quadriplegic myopathy 14 | 1,158
dermatomyositis 14 | 966
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Carcinoma, Hepatocellular 13 | 228
Congenital Epicanthus 13 | 177
Depressive disorder 13 | 409
Heart disease 13 | 306
High forehead 13 | 102
Hypertension 13 | 396
Liver carcinoma 13 | 240
Osteoporosis 13 | 363
Skin cancer 13 | 469
Tall forehead 13 | 102
Alzheimer's disease 12 | 658
Low set ears 12 | 181
Pectus excavatum 12 | 100
Strabismus 12 | 270

Tissue

Endocrine System 115 | 18,159
Digestive Tract 114 | 17,369
Liver and Pancreas 114 | 16,750
Male tissues 114 | 17,142
Female tissues 113 | 17,400
Skin and soft tissues 113 | 17,230
Blood and immune system 111 | 16,909
Cardiovascular System 111 | 15,192
Nervous System 110 | 16,725
Respiratory system 110 | 16,393
Urinary Tract 110 | 16,678

Target Family

Enzyme 35 | 4,145
Kinase 24 | 634
Non-IDG 21 | 12,091
Transporter 14 | 473
Epigenetic 9 | 242
Transcription Factor 7 | 1,400
Nuclear Receptor 6 | 48

KEGG Pathway

Thyroid hormone signaling path... 116 | 116
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331