Development Level

Tbio 58 | 11,445
Tchem 30 | 1,598
Tclin 15 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased vertical activity 3 | 208
male infertility 3 | 123
abnormal behavior 2 | 298
abnormal vertebrae morphology 2 | 18
decreased bone mineral density 2 | 126
decreased mean corpuscular vol... 2 | 79
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal eating behavior 1 | 1
abnormal eye anterior chamber ... 1 | 9
abnormal forced expiratory flo... 1 | 1
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased body temperature 1 | 2
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
decreased tidal volume 1 | 1
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
female infertility 1 | 60
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 56 | 11,493
Cancer 52 | 2,499
psoriasis 49 | 6,694
Rheumatoid arthritis 43 | 1,191
glioblastoma 42 | 5,792
ovarian cancer 42 | 8,520
lung cancer 41 | 4,740
osteosarcoma 41 | 7,950
lung carcinoma 32 | 2,843
medulloblastoma, large-cell 32 | 6,241
interstitial cystitis 27 | 2,312
atypical teratoid / rhabdoid tumor 26 | 5,112
malignant mesothelioma 26 | 3,232
Multiple Sclerosis 25 | 540
ependymoma 25 | 4,679
diabetes mellitus 24 | 1,728
tuberculosis 24 | 2,010
Astrocytoma, Pilocytic 23 | 3,081
Breast cancer 23 | 3,578
Schizophrenia 23 | 1,160
adult high grade glioma 22 | 3,801
invasive ductal carcinoma 22 | 2,951
sarcoidosis 21 | 370
Arthritis 20 | 290
Asthma 20 | 385
subependymal giant cell astrocytoma 20 | 2,287
Systemic lupus erythematosus 19 | 194
cutaneous lupus erythematosus 19 | 1,057
Hypersensitivity reaction type II disease 18 | 253
Autosomal recessive predisposition 17 | 1,442
Narcolepsy 17 | 72
astrocytoma 17 | 1,146
breast carcinoma 17 | 1,638
non-small cell lung cancer 17 | 2,890
oligodendroglioma 17 | 2,850
primitive neuroectodermal tumor 17 | 3,035
Berylliosis 16 | 28
Kidney cancer 16 | 2,613
group 3 medulloblastoma 16 | 4,104
group 4 medulloblastoma 16 | 1,855
lung adenocarcinoma 16 | 2,716
pancreatic cancer 16 | 2,398
ulcerative colitis 16 | 1,819
Immunologic Deficiency Syndromes 15 | 113
Arthritis, Rheumatoid 14 | 174
Crohn's disease 14 | 321
Multiple Sclerosis, Susceptibility to 14 | 15
Narcolepsy-cataplexy 14 | 21
astrocytic glioma 14 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Breast Neoplasms 13 | 445
Diffuse cutaneous systemic sclerosis 13 | 17
Lung Neoplasms 13 | 232
Lung disease 13 | 142
Mammary Neoplasms 13 | 425
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
Type 1 diabetes mellitus 13 | 109
follicular lymphoma 13 | 20
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
juvenile dermatomyositis 13 | 1,187
limited scleroderma 13 | 19
Inflammatory bowel disease 12 | 151
Juvenile rheumatoid arthritis 12 | 111
adrenocortical carcinoma 12 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
primary Sjogren syndrome 12 | 735
Brain Ischemia 11 | 110
Failure to gain weight 11 | 365
Pediatric failure to thrive 11 | 365
Pick disease 11 | 1,894
Severe combined immunodeficiency 11 | 51
ductal carcinoma in situ 11 | 1,745
esophageal adenocarcinoma 11 | 737
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
pituitary cancer 11 | 1,972
Arthralgia 10 | 90
Fever 10 | 138
Recurrent respiratory infections 10 | 141
Vascular disease 10 | 319
Waldenstrons macroglobulinemia 10 | 765
active Crohn's disease 10 | 922
colon cancer 10 | 1,478
Allergic hypersensitivity disease 9 | 126
Allergic rhinitis 9 | 94
Alzheimer's disease 9 | 658
Anemia 9 | 365
Dermatitis 9 | 157
Hepatitis B 9 | 108
Hypereosinophilic syndrome 9 | 71
Hypersensitivity 9 | 63
Kidney disease 9 | 430
Liver Cirrhosis, Experimental 9 | 769
Vasculitis 9 | 80
primary pancreatic ductal adenocarcinoma 9 | 1,109
Bipolar Disorder 8 | 666
Down syndrome 8 | 499
Duchenne muscular dystrophy 8 | 601
Multiple myeloma 8 | 1,332
cystic fibrosis 8 | 1,696

Tissue

Blood and immune system 87 | 16,909
Digestive Tract 87 | 17,369
Endocrine System 87 | 18,159
Liver and Pancreas 87 | 16,750
Skin and soft tissues 87 | 17,230
Male tissues 85 | 17,142
Respiratory system 85 | 16,393
Female tissues 84 | 17,400
Urinary Tract 84 | 16,678
Cardiovascular System 81 | 15,192
Nervous System 81 | 16,725

Target Family

Non-IDG 63 | 12,091
Kinase 19 | 634
Transcription Factor 18 | 1,400
Enzyme 4 | 4,145

KEGG Pathway

Th1 and Th2 cell differentiati... 104 | 104
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
HLA class II histocompatibility antigen, DRB1-9 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 0
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.60752 391.4 125
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 489