Development Level

Tbio 13 | 11,178
Tchem 7 | 1,885
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
microphthalmia 2 | 26
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal tooth morphology 1 | 24
anophthalmia 1 | 33
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating lipase l... 1 | 3
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased lymphocyte cell numb... 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 15 | 11,192
ovarian cancer 13 | 8,297
osteosarcoma 11 | 7,766
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,204
malignant mesothelioma 9 | 3,135
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,911
psoriasis 8 | 6,514
ductal carcinoma in situ 7 | 1,686
Breast cancer 5 | 3,469
Multiple myeloma 5 | 1,296
active Crohn's disease 5 | 882
invasive ductal carcinoma 5 | 2,867
medulloblastoma, large-cell 5 | 6,086
Autosomal recessive predisposition 4 | 1,407
Pick disease 4 | 1,856
Porokeratosis of Mibelli 4 | 4
lung adenocarcinoma 4 | 2,627
lung cancer 4 | 4,607
Disseminated superficial actinic porokeratosis 3 | 4
Osteoporosis 3 | 348
Porokeratosis, Disseminated Superficial Actinic 3 | 4
Progeria 3 | 25
Seizures 3 | 584
Waldenstrons macroglobulinemia 3 | 742
chronic rhinosinusitis 3 | 505
diabetes mellitus 3 | 1,683
group 3 medulloblastoma 3 | 4,002
posterior fossa group B ependymoma 3 | 406
Angina Pectoris 2 | 32
Aplasia/Hypoplasia of the skin 2 | 16
COENZYME Q10 DEFICIENCY, PRIMARY, 1 2 | 6
Cancer 2 | 2,388
Carcinoma, Hepatocellular 2 | 217
Cerebellar Ataxia 2 | 302
Coenzyme Q10 deficiency disease 2 | 8
Cognitive delay 2 | 596
Dull intelligence 2 | 634
Epilepsy 2 | 775
Failure to gain weight 2 | 359
Global developmental delay 2 | 596
Hallermann-Streiff syndrome 2 | 8
Hydrolethalus syndrome 2 | 126
Hyperkeratosis 2 | 50
Hyperlipidemia 2 | 43
Increased serum lactate 2 | 60
Intellectual disability 2 | 998
Keratosis 2 | 36
Kidney Failure, Chronic 2 | 45
Large bregma sutures 2 | 45
Large fontanelle 2 | 45
Large, late-closing fontanelle 2 | 45
Lipid metabolism disorder 2 | 111
Liver Cirrhosis, Experimental 2 | 733
Liver carcinoma 2 | 229
Low intelligence 2 | 634
Low set ears 2 | 178
Mental Retardation 2 | 634
Mental and motor retardation 2 | 596
Mental deficiency 2 | 634
Mitral valve insufficiency 2 | 48
Multiple acyl-CoA dehydrogenase deficiency 2 | 25
Muscle hypotonia 2 | 562
Obesity 2 | 655
Pediatric failure to thrive 2 | 359
Photosensitivity of skin 2 | 51
Poor school performance 2 | 634
Pruritus 2 | 56
Short stature 2 | 514
Vomiting 2 | 116
Wide bregma sutures 2 | 45
active ulcerative colitis 2 | 736
acute myeloid leukemia 2 | 760
adrenocortical carcinoma 2 | 1,385
beta-ketothiolase deficiency 2 | 13
colon cancer 2 | 1,428
fibroadenoma 2 | 538
gastric cancer 2 | 445
hepatocellular carcinoma 2 | 536
interstitial lung disease 2 | 287
nephrosclerosis 2 | 314
pancreatic cancer 2 | 2,322
spina bifida 2 | 1,053
tuberculosis 2 | 1,963
Bird-like facies 1 | 4
Bullet vertebral body 1 | 17
Dry Eye Syndromes 1 | 8
Familial hypercholesterolemia - heterozygous 1 | 5
Familial hypercholesterolemia - homozygous 1 | 6
Follicular mucinosis 1 | 4
Glucocorticoid Induced Osteoporosis 1 | 4
Hypogonadal Osteoporosis in Males 1 | 4
Insulin resistant diabetes 1 | 13
Keratitis sicca 1 | 6
Metaphyseal widening 1 | 19
Mixed hyperlipidemia 1 | 5
Ovoid vertebral bodies 1 | 17
POROKERATOSIS 9, MULTIPLE TYPES 1 | 1
Prevention of Glucocorticoid-Induced Osteoporosis 1 | 1

Tissue

Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Skin and soft tissues 22 | 17,230
Blood and immune system 21 | 16,909
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Respiratory system 21 | 16,393
Urinary Tract 21 | 16,678

Target Family

Enzyme 21 | 4,145
Kinase 1 | 634

KEGG Pathway

Terpenoid backbone biosynthesi... 22 | 22
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
CAAX prenyl protease 2 RCE1 Tchem Enzyme -1.85529 71.8 98
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR Tclin Enzyme -3.21450 1428.4 229
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tbio Enzyme -1.67608 43.7 137
Prenylcysteine oxidase 1 PCYOX1 Tbio Enzyme -0.61256 4.78 50
Decaprenyl-diphosphate synthase subunit 2 PDSS2 Tbio Enzyme -1.35453 23.3 163
Phosphomevalonate kinase PMVK Tbio Enzyme -1.96385 92.3 144
Decaprenyl-diphosphate synthase subunit 1 PDSS1 Tbio Enzyme -1.87900 72.4 49
CAAX prenyl protease 1 homolog ZMPSTE24 Tchem Enzyme -2.10187 125.8 321