Development Level

Tbio 53 | 11,651
Tchem 47 | 1,388
Tclin 8 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased circulating creatini... 4 | 39
increased circulating alkaline... 4 | 122
embryonic lethality prior to t... 3 | 278
increased leukocyte cell numbe... 3 | 47
increased neutrophil cell numb... 3 | 46
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal neural tube closure 2 | 46
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased eosinophil cell numb... 2 | 11
increased large unstained cell... 2 | 5
increased lymphocyte cell numb... 2 | 32
abnormal bone mineralization 1 | 38
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal esophagus morphology 1 | 5
abnormal forebrain development 1 | 20
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal skin condition 1 | 6
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 10
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
increased basophil cell number 1 | 7
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Cancer 82 | 2,499
Carcinoma 71 | 11,493
psoriasis 68 | 6,694
ovarian cancer 65 | 8,520
lung cancer 62 | 4,740
glioblastoma 61 | 5,792
osteosarcoma 44 | 7,950
atypical teratoid / rhabdoid tumor 41 | 5,112
medulloblastoma, large-cell 38 | 6,241
ependymoma 37 | 4,679
malignant mesothelioma 37 | 3,232
lung carcinoma 36 | 2,843
non-small cell lung cancer 34 | 2,890
tuberculosis 34 | 2,010
interstitial cystitis 33 | 2,312
Schizophrenia 32 | 1,160
adult high grade glioma 32 | 3,801
Arthritis 30 | 290
Breast cancer 30 | 3,578
cystic fibrosis 30 | 1,696
diabetes mellitus 30 | 1,728
ulcerative colitis 30 | 1,819
Astrocytoma, Pilocytic 26 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
lung adenocarcinoma 26 | 2,716
Asthma 25 | 385
Breast Neoplasms 25 | 445
Mammary Neoplasms 25 | 425
Rheumatoid arthritis 25 | 1,191
Obesity 24 | 678
pancreatic cancer 24 | 2,398
Inflammatory bowel disease 23 | 151
Multiple Sclerosis 23 | 540
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
subependymal giant cell astrocytoma 23 | 2,287
Kidney disease 22 | 430
Lung disease 22 | 142
Bipolar Disorder 21 | 666
Brain Ischemia 21 | 110
Vascular disease 21 | 319
Hypersensitivity reaction type II disease 20 | 253
cutaneous lupus erythematosus 20 | 1,057
group 3 medulloblastoma 20 | 4,104
invasive ductal carcinoma 20 | 2,951
pituitary cancer 20 | 1,972
primitive neuroectodermal tumor 20 | 3,035
Atherosclerosis 18 | 291
Kidney cancer 18 | 2,613
Lung Neoplasms 18 | 232
Reperfusion Injury 18 | 86
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Alzheimer's disease 17 | 658
Hyperglycemia 17 | 137
Myocardial Ischemia 17 | 169
colon cancer 17 | 1,478
group 4 medulloblastoma 17 | 1,855
juvenile dermatomyositis 17 | 1,187
Hypertension 16 | 396
active ulcerative colitis 16 | 764
acute myeloid leukemia 16 | 783
Coronary artery disease 15 | 268
Dermatitis 15 | 157
Heart disease 15 | 306
Liver Cirrhosis, Experimental 15 | 769
Liver disease 15 | 237
active Crohn's disease 15 | 922
astrocytoma 15 | 1,146
breast carcinoma 15 | 1,638
gastric carcinoma 15 | 807
Cerebrovascular disease 14 | 238
Depressive disorder 14 | 409
Diabetes Mellitus, Experimental 14 | 108
Endometriosis 14 | 540
Parkinson's disease 14 | 392
Pneumonia 14 | 174
esophageal adenocarcinoma 14 | 737
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Hypertensive disease 13 | 292
Liver carcinoma 13 | 240
Mental Depression 13 | 333
Prostatic Neoplasms 13 | 495
Stomach Neoplasms 13 | 300
Toxic encephalopathy 13 | 141
adrenocortical carcinoma 13 | 1,428
nasopharyngeal carcinoma 13 | 1,058
Brain Injuries 12 | 65
Carcinoma, Hepatocellular 12 | 228
Cardiomyopathies 12 | 110
Cholestasis, Extrahepatic 12 | 25
Diabetes Mellitus, Non-Insulin-Dependent 12 | 145
Hyperalgesia 12 | 83
Inflammation 12 | 120
Pick disease 12 | 1,894
Seizures 12 | 596
oligodendroglioma 12 | 2,850
periodontitis 12 | 293
posterior fossa group A ependymoma 12 | 468
primary pancreatic ductal adenocarcinoma 12 | 1,109
spina bifida 12 | 1,074
primary Sjogren syndrome 11 | 735

Tissue

Blood and immune system 108 | 16,909
Digestive Tract 108 | 17,369
Endocrine System 108 | 18,159
Urinary Tract 108 | 16,678
Female tissues 107 | 17,400
Liver and Pancreas 107 | 16,750
Respiratory system 107 | 16,393
Skin and soft tissues 107 | 17,230
Male tissues 106 | 17,142
Nervous System 106 | 16,725
Cardiovascular System 101 | 15,192

Target Family

Non-IDG 45 | 12,091
Kinase 34 | 634
Transcription Factor 16 | 1,400
Enzyme 13 | 4,145

KEGG Pathway

TNF signaling pathway 108 | 108
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
E-selectin SELE Tchem Non-IDG -3.44926 2672.1 919
C-X-C motif chemokine 5 CXCL5 Tbio Non-IDG -2.44551 266.4 370
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Cyclic AMP-dependent transcription factor ATF-6 beta ATF6B Tbio Transcription Factor -1.03459 8.22 6
Cyclic AMP-responsive element-binding protein 5 CREB5 Tbio Transcription Factor -0.88055 7.80 164
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765