Development Level

Tbio 64 | 11,445
Tchem 17 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal lung morphology 2 | 26
abnormal tooth morphology 2 | 24
corneal opacity 2 | 32
decreased body weight 2 | 161
decreased startle reflex 2 | 75
edema 2 | 59
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
irregularly shaped pupil 2 | 7
prenatal lethality 2 | 28
small testis 2 | 58
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal gait 1 | 69
abnormal head size 1 | 6
abnormal incisor morphology 1 | 4
abnormal iris morphology 1 | 13
abnormal liver morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal placement of pupils 1 | 6
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal ulna morphology 1 | 8
anophthalmia 1 | 33
decreased B cell number 1 | 5
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
male infertility 1 | 123
microphthalmia 1 | 26
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 54 | 11,493
ovarian cancer 52 | 8,520
Cancer 48 | 2,499
osteosarcoma 48 | 7,950
psoriasis 42 | 6,694
glioblastoma 36 | 5,792
atypical teratoid / rhabdoid tumor 34 | 5,112
medulloblastoma, large-cell 34 | 6,241
Breast cancer 28 | 3,578
Astrocytoma, Pilocytic 27 | 3,081
ependymoma 27 | 4,679
malignant mesothelioma 27 | 3,232
group 3 medulloblastoma 26 | 4,104
lung cancer 26 | 4,740
adult high grade glioma 25 | 3,801
lung carcinoma 21 | 2,843
invasive ductal carcinoma 20 | 2,951
cystic fibrosis 19 | 1,696
interstitial cystitis 19 | 2,312
lung adenocarcinoma 19 | 2,716
Kidney cancer 17 | 2,613
non-small cell lung cancer 17 | 2,890
oligodendroglioma 17 | 2,850
pancreatic cancer 17 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
pituitary cancer 16 | 1,972
primitive neuroectodermal tumor 16 | 3,035
Liver Cirrhosis, Experimental 15 | 769
ductal carcinoma in situ 15 | 1,745
group 4 medulloblastoma 14 | 1,855
acute quadriplegic myopathy 13 | 1,158
astrocytic glioma 13 | 2,597
diabetes mellitus 13 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
primary pancreatic ductal adenocarcinoma 13 | 1,109
tuberculosis 13 | 2,010
ulcerative colitis 13 | 1,819
Osteoarthritis 12 | 184
Pick disease 12 | 1,894
Schizophrenia 12 | 1,160
Stomach Neoplasms 12 | 300
breast carcinoma 12 | 1,638
Kidney disease 11 | 430
subependymal giant cell astrocytoma 11 | 2,287
Breast Neoplasms 10 | 445
Cleft Palate 10 | 271
Hypertensive disease 10 | 292
Mammary Neoplasms 10 | 425
Multiple myeloma 10 | 1,332
Rheumatoid arthritis 10 | 1,191
Short stature 10 | 531
colon cancer 10 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Acquired flat foot 9 | 72
Acquired scoliosis 9 | 281
Coronary artery disease 9 | 268
Craniofacial Abnormalities 9 | 151
Curvature of spine 9 | 282
Fibrodysplasia ossificans progressiva 9 | 17
Flatfoot 9 | 73
Lung Neoplasms 9 | 232
Vascular disease 9 | 319
active Crohn's disease 9 | 922
active ulcerative colitis 9 | 764
astrocytoma 9 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Heart disease 8 | 306
Hypertension 8 | 396
Neoplasm Invasiveness 8 | 161
Orbital separation excessive 8 | 244
Polycystic ovary syndrome 8 | 360
Prostatic Neoplasms 8 | 495
Pulmonary Fibrosis 8 | 106
acute myeloid leukemia 8 | 783
juvenile dermatomyositis 8 | 1,187
nasopharyngeal carcinoma 8 | 1,058
pediatric high grade glioma 8 | 1,064
Asthma 7 | 385
Autosomal recessive predisposition 7 | 1,442
Bilateral fifth finger clinodactyly 7 | 110
Brachydactyly 7 | 156
Broad hallux 7 | 29
Byzanthine arch palate 7 | 194
Colorectal Neoplasms 7 | 243
Curvature of little finger 7 | 110
Glaucoma 7 | 239
Increase in blood pressure 7 | 119
Neoplasm Metastasis 7 | 168
Squamous cell carcinoma 7 | 129
Ureteral obstruction 7 | 33
Waldenstrons macroglobulinemia 7 | 765
adrenocortical carcinoma 7 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
mucosa-associated lymphoid tissue lymphoma 7 | 484
Bipolar Disorder 6 | 666
Duchenne muscular dystrophy 6 | 601
Endometriosis 6 | 540
cutaneous lupus erythematosus 6 | 1,057
dermatomyositis 6 | 966
esophageal adenocarcinoma 6 | 737

Tissue

Endocrine System 83 | 18,159
Female tissues 82 | 17,400
Liver and Pancreas 82 | 16,750
Male tissues 82 | 17,142
Skin and soft tissues 82 | 17,230
Urinary Tract 82 | 16,678
Digestive Tract 81 | 17,369
Nervous System 81 | 16,725
Blood and immune system 79 | 16,909
Cardiovascular System 79 | 15,192
Respiratory system 79 | 16,393

Target Family

Non-IDG 35 | 12,091
Transcription Factor 20 | 1,400
Kinase 16 | 634
Enzyme 10 | 4,145
Epigenetic 2 | 242

KEGG Pathway

TGF-beta signaling pathway 83 | 83
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
Neuroblastoma suppressor of tumorigenicity 1 NBL1 Tbio Non-IDG -2.58132 362.9 217
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.43406 2729.3 264
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684
Bone morphogenetic protein 6 BMP6 Tbio Non-IDG -2.55269 373.2 317
Growth/differentiation factor 6 GDF6 Tbio Non-IDG -2.31035 205.4 110