Development Level

Tbio 7 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal body wall morphology 1 | 9
abnormal embryo size 1 | 220
anophthalmia 1 | 33
increased body length 1 | 32
increased mean corpuscular hem... 1 | 96
microphthalmia 1 | 26
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 8 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
psoriasis 5 | 6,694
Pick disease 4 | 1,894
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
malignant mesothelioma 4 | 3,232
medulloblastoma, large-cell 4 | 6,241
Autosomal recessive predisposition 3 | 1,442
active Crohn's disease 3 | 922
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
beta-ketothiolase deficiency 3 | 13
colon cancer 3 | 1,478
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
interstitial cystitis 3 | 2,312
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
ovarian cancer 3 | 8,520
primitive neuroectodermal tumor 3 | 3,035
Astrocytoma, Pilocytic 2 | 3,081
Hydrolethalus syndrome 2 | 128
Hypoglycemia 2 | 152
Ketoacidosis, episodic 2 | 4
Liver Cirrhosis, Experimental 2 | 769
Seizures 2 | 596
Vomiting 2 | 116
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 764
astrocytic glioma 2 | 2,597
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
nephrosclerosis 2 | 333
non-small cell lung cancer 2 | 2,890
osteosarcoma 2 | 7,950
subependymal giant cell astrocytoma 2 | 2,287
3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency 1 | 1
3-Methylcrotonyl-CoA carboxylase deficiency 1 | 11
3-methylglutaconic aciduria 1 | 29
Acetyl-Coa Acetyltransferase-2 Deficiency 1 | 1
Alzheimer's disease 1 | 658
Argininosuccinic aciduria 1 | 17
Breast cancer 1 | 3,578
Carnitine deficiency 1 | 6
Chemical and Drug Induced Liver Injury 1 | 195
Chorea 1 | 29
Choreatic disease 1 | 52
Chromosome 3q29 microduplication syndrome 1 | 6
Colonic Neoplasms 1 | 142
Comatose 1 | 56
Cytosolic acetoacetyl-CoA thiolase deficiency 1 | 1
Death in childhood 1 | 14
Dehydration 1 | 40
Epilepsy 1 | 792
Fever 1 | 138
Gastric antral vascular ectasia 1 | 10
Gaucher disease type 1 1 | 180
Gaucher's disease 1 | 26
Glutaric aciduria 1 | 5
Hepatomegaly 1 | 285
Hyperammonemia 1 | 30
Hyperargininemia 1 | 8
Increased serum lactate 1 | 60
Increased serum pyruvate 1 | 9
Isolated cases 1 | 72
Isovaleric acidemia 1 | 15
Kidney Failure, Chronic 1 | 46
Male infertility 1 | 206
Maple syrup urine disease 1 | 24
Medium chain acyl-CoA dehydrogenase deficiency 1 | 13
Metabolic acidosis 1 | 90
Methylmalonic acidemia 1 | 37
Mouth Neoplasms 1 | 55
Multiple carboxylase deficiency 1 | 7
Myocardial Ischemia 1 | 169
Neoplasm Invasiveness 1 | 161
Osteoporosis 1 | 363
Propionic acidemia 1 | 16
Recurrence 1 | 33
Reye syndrome 1 | 11
Short chain acyl-CoA dehydrogenase deficiency 1 | 9
Somnolence 1 | 15
Tachypnea 1 | 20
Very long chain acyl-CoA dehydrogenase deficiency 1 | 10
adrenocortical carcinoma 1 | 1,428
atypical teratoid/rhabdoid tumor 1 | 357
chronic rhinosinusitis 1 | 512
diabetes mellitus 1 | 1,728
fibroadenoma 1 | 559
mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency 1 | 1
pancreatic cancer 1 | 2,398
posterior fossa group B ependymoma 1 | 416
spina bifida 1 | 1,074
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Enzyme 10 | 4,145

KEGG Pathway

Synthesis and degradation of k... 10 | 10
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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