Development Level

Tbio 53 | 11,651
Tchem 4 | 1,388
Tdark 4 | 6,593
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to t... 9 | 278
embryonic lethality prior to o... 8 | 239
abnormal behavior 3 | 298
decreased total body fat amoun... 3 | 207
abnormal seminal vesicle morph... 2 | 114
decreased mean corpuscular vol... 2 | 79
hyperactivity 2 | 148
preweaning lethality, incomple... 2 | 499
abnormal cecum morphology 1 | 7
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal kidney morphology 1 | 65
abnormal testis morphology 1 | 43
absent pinna reflex 1 | 23
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 40 | 11,493
ependymoma 33 | 4,679
glioblastoma 32 | 5,792
atypical teratoid / rhabdoid tumor 30 | 5,112
oligodendroglioma 30 | 2,850
astrocytic glioma 29 | 2,597
medulloblastoma, large-cell 29 | 6,241
ovarian cancer 29 | 8,520
psoriasis 27 | 6,694
adult high grade glioma 26 | 3,801
Astrocytoma, Pilocytic 25 | 3,081
Pick disease 23 | 1,894
group 3 medulloblastoma 23 | 4,104
primitive neuroectodermal tumor 22 | 3,035
lung carcinoma 20 | 2,843
osteosarcoma 20 | 7,950
subependymal giant cell astrocytoma 18 | 2,287
Kidney cancer 15 | 2,613
Schizophrenia 14 | 1,160
lung cancer 12 | 4,740
Bipolar Disorder 11 | 666
Epilepsy 10 | 792
Parkinson's disease 10 | 392
pituitary cancer 10 | 1,972
Breast cancer 9 | 3,578
malignant mesothelioma 9 | 3,232
Alzheimer's disease 8 | 658
Multiple myeloma 8 | 1,332
invasive ductal carcinoma 7 | 2,951
Depressive disorder 6 | 409
Intellectual disability 6 | 1,016
Mental Depression 6 | 333
Autosomal recessive predisposition 5 | 1,442
Osteopetrosis 5 | 43
Seizures 5 | 596
Tetanus 5 | 68
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
spina bifida 5 | 1,074
tuberculosis 5 | 2,010
Anemia 4 | 365
Attention deficit hyperactivity disorder 4 | 278
Blepharoptosis 4 | 231
Botulism 4 | 24
Cataract 8 multiple types 4 | 33
Cocaine Dependence 4 | 51
Cognitive delay 4 | 608
Failure to gain weight 4 | 365
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Pediatric failure to thrive 4 | 365
Psychotic Disorders 4 | 151
Rheumatoid arthritis 4 | 1,191
active Crohn's disease 4 | 922
acute quadriplegic myopathy 4 | 1,158
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
medulloblastoma 4 | 720
Autistic Disorder 3 | 364
Broad flat nasal bridge 3 | 236
Cerebellar Ataxia 3 | 304
Cutis Laxa 3 | 39
Diarrhea 3 | 253
Dysarthria 3 | 192
Gaucher disease type 1 3 | 180
Hypomyelinating leukodystrophy 6 3 | 26
Liver cancer 3 | 604
Nasal bridge wide 3 | 236
Neurodegenerative disease 3 | 414
Nystagmus 3 | 317
Prenatal onset 3 | 139
Reduced fetal movement 3 | 51
Sensorineural hearing loss 3 | 106
Short stature 3 | 531
Tremor 3 | 113
Waldenstrons macroglobulinemia 3 | 765
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
non primary Sjogren syndrome sicca 3 | 891
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Contracture 2 | 96
Contracture of joint 2 | 93
Difficulty walking 2 | 28
Dystonia 2 | 164
Flexion contracture 2 | 93
Low Vision 2 | 174
Progressive disorder 2 | 142
Reflex, Deep Tendon, Absent 2 | 92
Severe mental retardation (I.Q. 20-34) 2 | 99
tuberculosis and treatment for 6 months 2 | 409

Tissue

Endocrine System 61 | 18,159
Nervous System 60 | 16,725
Skin and soft tissues 60 | 17,230
Blood and immune system 59 | 16,909
Digestive Tract 59 | 17,369
Female tissues 59 | 17,400
Male tissues 59 | 17,142
Urinary Tract 57 | 16,678
Respiratory system 56 | 16,393
Liver and Pancreas 55 | 16,750
Cardiovascular System 51 | 15,192

Target Family

Non-IDG 29 | 12,091
Enzyme 25 | 4,145
Transporter 7 | 473
Ion Channel 2 | 344

KEGG Pathway

Synaptic vesicle cycle 63 | 63
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase subunit B, kidney isoform ATP6V1B1 Tchem Enzyme -1.71459 43.7 251
V-type proton ATPase subunit D ATP6V1D Tbio Enzyme -1.48812 30.2 69
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.46402 298.9 76
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.42073 25.5 108
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.59767 34.8 212
V-type proton ATPase 16 kDa proteolipid subunit ATP6V0C Tbio Enzyme -1.87899 78.9 72
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.65996 4.74 124
Vesicular glutamate transporter 3 SLC17A8 Tbio Transporter -2.00898 110.3 57
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.53335 323.7 203
V-type proton ATPase 116 kDa subunit a isoform 1 ATP6V0A1 Tbio Enzyme -1.40105 25.1 63