Development Level

Tchem 51 | 1,598
Tbio 50 | 11,445
Tclin 17 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 6 | 499
abnormal bone structure 4 | 187
increased circulating alkaline... 4 | 122
male infertility 4 | 123
decreased body weight 3 | 161
decreased mean corpuscular hem... 3 | 50
decreased total body fat amoun... 3 | 207
hypoactivity 3 | 132
increased lean body mass 3 | 172
increased leukocyte cell numbe... 3 | 47
abnormal behavior 2 | 298
abnormal gait 2 | 69
abnormal locomotor behavior 2 | 24
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
increased bone mineral content 2 | 108
increased hematocrit 2 | 46
increased lymphocyte cell numb... 2 | 32
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal gallbladder morpholog... 1 | 1
abnormal glucose homeostasis 1 | 4
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
female infertility 1 | 60
hydrometra 1 | 53
increased basophil cell number 1 | 7
increased cardiac muscle contr... 1 | 8
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
premature death 1 | 5
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 91 | 11,493
ovarian cancer 71 | 8,520
glioblastoma 62 | 5,792
osteosarcoma 58 | 7,950
medulloblastoma, large-cell 54 | 6,241
psoriasis 51 | 6,694
Cancer 50 | 2,499
atypical teratoid / rhabdoid tumor 49 | 5,112
ependymoma 45 | 4,679
lung cancer 42 | 4,740
Astrocytoma, Pilocytic 37 | 3,081
adult high grade glioma 37 | 3,801
group 3 medulloblastoma 34 | 4,104
invasive ductal carcinoma 32 | 2,951
Breast cancer 30 | 3,578
malignant mesothelioma 30 | 3,232
tuberculosis 28 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
primitive neuroectodermal tumor 27 | 3,035
subependymal giant cell astrocytoma 27 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
group 4 medulloblastoma 25 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
non-small cell lung cancer 25 | 2,890
oligodendroglioma 25 | 2,850
Schizophrenia 24 | 1,160
astrocytic glioma 24 | 2,597
lung adenocarcinoma 23 | 2,716
Kidney cancer 22 | 2,613
interstitial cystitis 22 | 2,312
Epilepsy 21 | 792
lung carcinoma 21 | 2,843
pancreatic cancer 21 | 2,398
breast carcinoma 19 | 1,638
Intellectual disability 18 | 1,016
Vascular disease 18 | 319
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Multiple myeloma 17 | 1,332
Pick disease 17 | 1,894
Poor school performance 17 | 645
diabetes mellitus 17 | 1,728
ductal carcinoma in situ 17 | 1,745
ulcerative colitis 17 | 1,819
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
Melanoma 16 | 711
Stomach Neoplasms 16 | 300
Alzheimer's disease 15 | 658
Rheumatoid arthritis 15 | 1,191
juvenile dermatomyositis 15 | 1,187
Autosomal recessive predisposition 14 | 1,442
Bipolar Disorder 14 | 666
Seizures 14 | 596
pituitary cancer 14 | 1,972
Asthma 13 | 385
Cognitive delay 13 | 608
Depressive disorder 13 | 409
Diabetes Mellitus, Experimental 13 | 108
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Orbital separation excessive 13 | 244
astrocytoma 13 | 1,146
cystic fibrosis 13 | 1,696
Big calvaria 12 | 147
Hypertension 12 | 396
Increased head circumference 12 | 147
Increased size of cranium 12 | 147
Increased size of skull 12 | 147
Lung Neoplasms 12 | 232
Prostatic Neoplasms 12 | 495
Waldenstrons macroglobulinemia 12 | 765
colon cancer 12 | 1,478
cutaneous lupus erythematosus 12 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Downward slant of palpebral fissure 11 | 158
Heart disease 11 | 306
Liver Cirrhosis, Experimental 11 | 769
Neoplasm Invasiveness 11 | 161
Neurodegenerative disease 11 | 414
Splenomegaly 11 | 190
spina bifida 11 | 1,074
Brain Ischemia 10 | 110
Colorectal Neoplasms 10 | 243
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Hyperalgesia 10 | 83
Lung disease 10 | 142
Multiple Sclerosis 10 | 540
Muscle hypotonia 10 | 571
Neoplasm Metastasis 10 | 168
Short stature 10 | 531
adrenocortical carcinoma 10 | 1,428
primary pancreatic ductal adenocarcinoma 10 | 1,109
Hypoplastic mandible condyle 9 | 275
dermatomyositis 9 | 966
primary Sjogren syndrome 9 | 735

Tissue

Blood and immune system 117 | 16,909
Digestive Tract 117 | 17,369
Endocrine System 117 | 18,159
Female tissues 117 | 17,400
Liver and Pancreas 117 | 16,750
Male tissues 117 | 17,142
Skin and soft tissues 117 | 17,230
Nervous System 116 | 16,725
Respiratory system 115 | 16,393
Urinary Tract 115 | 16,678
Cardiovascular System 112 | 15,192

Target Family

Enzyme 51 | 4,145
Kinase 31 | 634
Non-IDG 18 | 12,091
GPCR 9 | 408
Transcription Factor 8 | 1,400
Transporter 1 | 473

KEGG Pathway

Sphingolipid signaling pathway 118 | 118
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Sphingosine-1-phosphate phosphatase 2 SGPP2 Tbio Enzyme -0.72925 6.15 77
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Ceramide synthase 6 CERS6 Tbio Transcription Factor -1.48442 32.4 167