Development Level

Tbio 33 | 10,625
Tchem 12 | 1,890
Tclin 2 | 602

IMPC Phenotype

decreased NK T cell number 2 | 28
male infertility 2 | 62
preweaning lethality, complete... 2 | 633
abnormal hair growth 1 | 8
abnormal motor coordination- b... 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
decreased CD5-positive gamma-d... 1 | 3
decreased CD8-positive, alpha-... 1 | 26
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased effector memory CD8-... 1 | 24
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
increased CD4-positive, CD25-p... 1 | 18
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased effector memory CD8-... 1 | 14
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
preweaning lethality, incomple... 1 | 260
sparse hair 1 | 6
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 27 | 8,491
glioblastoma 20 | 5,572
medulloblastoma, large-cell 17 | 6,234
osteosarcoma 17 | 7,933
psoriasis 16 | 6,685
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
pilocytic astrocytoma 15 | 3,086
atypical teratoid / rhabdoid tumor 12 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
malignant mesothelioma 12 | 3,163
Breast cancer 11 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
invasive ductal carcinoma 10 | 2,950
non-small cell lung cancer 10 | 2,798
tuberculosis 10 | 1,563
ductal carcinoma in situ 8 | 1,745
lung adenocarcinoma 8 | 2,714
lung cancer 8 | 4,473
lung carcinoma 8 | 2,844
pancreatic cancer 8 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
pituitary cancer 8 | 1,972
cystic fibrosis 7 | 1,670
posterior fossa group B ependymoma 7 | 1,530
subependymal giant cell astrocytoma 7 | 2,287
Atopic dermatitis 6 | 944
Down syndrome 6 | 548
Farber lipogranulomatosis 6 | 9
Multiple myeloma 6 | 1,327
adult high grade glioma 6 | 2,148
colon cancer 6 | 1,475
ependymoma 6 | 2,514
interstitial cystitis 6 | 2,299
primary pancreatic ductal adenocarcinoma 6 | 1,271
Cancer 5 | 2,346
Gaucher's disease 5 | 25
Glycoproteinosis 5 | 13
Neurodegenerative disease 5 | 383
Pick disease 5 | 1,893
aldosterone-producing adenoma 5 | 664
breast carcinoma 5 | 1,614
group 3 medulloblastoma 5 | 2,254
group 4 medulloblastoma 5 | 1,875
pediatric high grade glioma 5 | 2,712
posterior fossa group A ependymoma 5 | 1,511
ulcerative colitis 5 | 2,087
Alzheimer's disease 4 | 644
Gangliosidosis 4 | 17
Krabbe disease 4 | 11
Niemann-Pick disease 4 | 11
Peripheral Neuropathy 4 | 303
Rheumatoid Arthritis 4 | 1,170
active Crohn's disease 4 | 918
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
cutaneous lupus erythematosus 4 | 1,056
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,663
mucosa-associated lymphoid tissue lymphoma 4 | 480
oligodendroglioma 4 | 2,849
Carcinoma 3 | 2,147
IGA Glomerulonephritis 3 | 454
Lipid storage disease 3 | 7
Metachromatic leukodystrophy 3 | 13
Multiple Sclerosis 3 | 498
Neuropathy 3 | 210
Posterior amorphous corneal dystrophy 3 | 9
active ulcerative colitis 3 | 477
acute quadriplegic myopathy 3 | 1,157
adrenocortical carcinoma 3 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
esophageal adenocarcinoma 3 | 737
facioscapulohumeral dystrophy 3 | 286
inclusion-cell disease 3 | 15
juvenile dermatomyositis 3 | 1,189
medulloblastoma 3 | 1,524
nasopharyngeal carcinoma 3 | 1,056
progressive supranuclear palsy 3 | 674
sonic hedgehog group medulloblastoma 3 | 1,482
spina bifida 3 | 1,064
urothelial carcinoma 3 | 318
Amyotrophic Lateral Sclerosis 2 | 432
Bipolar Disorder 2 | 266
Cerebrovascular disease 2 | 231
Epilepsy 2 | 346
Heart disease 2 | 279
Hereditary Sensory Autonomic Neuropathy, Type 1 2 | 4
Leukemia 2 | 88
Leukodystrophy 2 | 30
MYELODYSPLASTIC SYNDROME 2 | 39
Mucopolysaccharidosis 2 | 24
Niemann-Pick disease, type C 2 | 5
acute myeloid leukemia 2 | 785
atypical teratoid/rhabdoid tumor 2 | 1,095
chronic lymphosyte leukemia 2 | 232
hepatocellular carcinoma 2 | 550
non diabetic and post-ischemic heart failure 2 | 200
non primary Sjogren syndrome sicca 2 | 840
primary Sjogren syndrome 2 | 788
primitive neuroectodermal tumor 2 | 3,031

Tissue

Cardiovascular System 47 | 17,957
Digestive Tract 46 | 18,472
Female tissues 46 | 18,646
Liver and Pancreas 46 | 18,135
Nervous System 46 | 18,560
Skin and soft tissues 46 | 18,114
Urinary Tract 46 | 18,443
Endocrine System 45 | 18,511
Male tissues 45 | 17,968
Blood and immune system 44 | 17,994
Respiratory system 44 | 17,483

Target Family

Enzyme 39 | 4,146
Transcription Factor 5 | 1,400
Kinase 3 | 634

KEGG Pathway

Sphingolipid metabolism 47 | 47
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ceramide synthase 1 CERS1 Tbio Enzyme -1.57090 34.6 153
Phospholipid phosphatase 2 PLPP2 Tbio Enzyme -1.33905 20.8 93
Ceramide synthase 6 CERS6 Tbio Transcription Factor -1.41026 28.5 155
Sphingosine-1-phosphate phosphatase 1 SGPP1 Tbio Enzyme -0.82819 5.89 64
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.67625 514.1 477
Ceramide synthase 5 CERS5 Tbio Transcription Factor -1.28892 17.6 143
Sphingosine-1-phosphate lyase 1 SGPL1 Tchem Enzyme -2.02204 102.8 120
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.14819 131.7 250
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 ENPP7 Tbio Enzyme -1.43177 28.7 184
Neutral ceramidase ASAH2 Tbio Enzyme -1.81260 64.5 121