Development Level

Tbio 33 | 11,651
Tchem 12 | 1,388
Tclin 2 | 612

IMPC Phenotype

male infertility 3 | 123
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal hair growth 1 | 10
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 31 | 11,493
ovarian cancer 27 | 8,520
glioblastoma 20 | 5,792
medulloblastoma, large-cell 17 | 6,241
osteosarcoma 17 | 7,950
psoriasis 16 | 6,694
Astrocytoma, Pilocytic 15 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
atypical teratoid / rhabdoid tumor 13 | 5,112
ependymoma 12 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
malignant mesothelioma 12 | 3,232
Breast cancer 11 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
invasive ductal carcinoma 10 | 2,951
non-small cell lung cancer 10 | 2,890
tuberculosis 10 | 2,010
Autosomal recessive predisposition 8 | 1,442
adult high grade glioma 8 | 3,801
ductal carcinoma in situ 8 | 1,745
group 3 medulloblastoma 8 | 4,104
lung adenocarcinoma 8 | 2,716
lung cancer 8 | 4,740
lung carcinoma 8 | 2,843
pancreatic cancer 8 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
pituitary cancer 8 | 1,972
Atopic dermatitis 7 | 952
Epilepsy 7 | 792
Multiple myeloma 7 | 1,332
cystic fibrosis 7 | 1,696
subependymal giant cell astrocytoma 7 | 2,287
Cancer 6 | 2,499
Down syndrome 6 | 499
Dull intelligence 6 | 645
Farber lipogranulomatosis 6 | 9
Intellectual disability 6 | 1,016
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Short stature 6 | 531
colon cancer 6 | 1,478
group 4 medulloblastoma 6 | 1,855
interstitial cystitis 6 | 2,312
primary pancreatic ductal adenocarcinoma 6 | 1,109
Cerebellar Ataxia 5 | 304
Gait abnormality 5 | 135
Gaucher's disease 5 | 26
Glycoproteinosis 5 | 12
Hepatomegaly 5 | 285
Liver Cirrhosis, Experimental 5 | 769
Muscle hypotonia 5 | 571
Myoclonic Epilepsies, Progressive 5 | 44
Neurodegenerative disease 5 | 414
Pick disease 5 | 1,894
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
Splenomegaly 5 | 190
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
astrocytic glioma 5 | 2,597
breast carcinoma 5 | 1,638
Alzheimer's disease 4 | 658
Cherry red spot of the macula 4 | 7
Failure to gain weight 4 | 365
Gangliosidosis 4 | 20
Kidney cancer 4 | 2,613
Krabbe disease 4 | 12
Neuronal ceroid lipofuscinosis 9 4 | 5
Niemann-Pick disease 4 | 14
Optic Atrophy 4 | 242
Pediatric failure to thrive 4 | 365
active Crohn's disease 4 | 922
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
mucosa-associated lymphoid tissue lymphoma 4 | 484
oligodendroglioma 4 | 2,850
Acquired scoliosis 3 | 281
Curvature of spine 3 | 282
Dementia 3 | 175
Dystonia 3 | 164
Electroencephalogram abnormal 3 | 101
Hyperreflexia 3 | 209
Multiple Sclerosis 3 | 540
Neuropathy 3 | 261
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
esophageal adenocarcinoma 3 | 737
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
posterior fossa group B ependymoma 3 | 416
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
ulcerative colitis 3 | 1,819
urothelial carcinoma 3 | 318

Tissue

Blood and immune system 45 | 16,909
Digestive Tract 45 | 17,369
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Skin and soft tissues 45 | 17,230
Endocrine System 44 | 18,159
Male tissues 44 | 17,142
Urinary Tract 44 | 16,678
Nervous System 43 | 16,725
Cardiovascular System 42 | 15,192
Respiratory system 42 | 16,393

Target Family

Enzyme 39 | 4,145
Transcription Factor 5 | 1,400
Kinase 3 | 634

KEGG Pathway

Sphingolipid metabolism 47 | 47
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Sphingomyelin phosphodiesterase 3 SMPD3 Tbio Enzyme -1.84613 78.5 126
Arylsulfatase A ARSA Tbio Enzyme -2.50334 319.0 337
Galactosylceramide sulfotransferase GAL3ST1 Tbio Enzyme -1.20030 12.8 113
Sialidase-4 NEU4 Tchem Enzyme -1.39624 25.1 115
Sialidase-2 NEU2 Tbio Enzyme -2.12721 129.5 166
Serine palmitoyltransferase 3 SPTLC3 Tbio Enzyme -1.26166 18.5 24
Acid ceramidase ASAH1 Tchem Enzyme -2.94716 848.0 203
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.72994 583.6 518