Development Level

Tbio 90 | 11,445
Tchem 31 | 1,598
Tclin 15 | 613
Tdark 2 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 18 | 979
abnormal embryo size 8 | 220
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to o... 5 | 239
abnormal heart morphology 4 | 162
decreased body weight 4 | 161
decreased vertical activity 4 | 208
microphthalmia 4 | 26
abnormal bone structure 3 | 187
anophthalmia 3 | 33
decreased startle reflex 3 | 75
prenatal lethality 3 | 28
abnormal bone mineralization 2 | 38
abnormal brain morphology 2 | 13
abnormal craniofacial morpholo... 2 | 33
abnormal eye morphology 2 | 68
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
impaired glucose tolerance 2 | 75
increased body length 2 | 32
increased bone mineral density 2 | 72
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye size 1 | 7
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal heart looping 1 | 5
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
aorta stenosis 1 | 2
cataract 1 | 92
decreased B cell number 1 | 5
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased mean platelet volume 1 | 25
decreased threshold for audito... 1 | 26
hydroencephaly 1 | 14
hydrometra 1 | 53
hydrops fetalis 1 | 1
increased CD4-positive, alpha ... 1 | 4
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating insulin ... 1 | 3
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
pallor 1 | 34
polydactyly 1 | 7
protruding tongue 1 | 3
small adrenal glands 1 | 16
small heart 1 | 10
small spleen 1 | 19
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 105 | 11,493
ovarian cancer 84 | 8,520
Cancer 78 | 2,499
psoriasis 70 | 6,694
osteosarcoma 68 | 7,950
medulloblastoma, large-cell 57 | 6,241
lung cancer 55 | 4,740
glioblastoma 54 | 5,792
atypical teratoid / rhabdoid tumor 52 | 5,112
group 3 medulloblastoma 49 | 4,104
ependymoma 47 | 4,679
Breast cancer 46 | 3,578
malignant mesothelioma 37 | 3,232
Kidney cancer 36 | 2,613
oligodendroglioma 33 | 2,850
invasive ductal carcinoma 32 | 2,951
Astrocytoma, Pilocytic 30 | 3,081
interstitial cystitis 30 | 2,312
adult high grade glioma 28 | 3,801
breast carcinoma 28 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
non-small cell lung cancer 27 | 2,890
lung adenocarcinoma 26 | 2,716
astrocytic glioma 25 | 2,597
primitive neuroectodermal tumor 25 | 3,035
Intellectual disability 24 | 1,016
Schizophrenia 24 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
Autosomal recessive predisposition 23 | 1,442
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
Short stature 23 | 531
cystic fibrosis 23 | 1,696
ductal carcinoma in situ 23 | 1,745
subependymal giant cell astrocytoma 23 | 2,287
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Mental and motor retardation 22 | 608
Orbital separation excessive 22 | 244
Pick disease 21 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
pituitary cancer 21 | 1,972
Hypoplastic mandible condyle 20 | 275
Mandibular hypoplasia 20 | 275
Micrognathism 20 | 275
Prostatic Neoplasms 20 | 495
pancreatic cancer 20 | 2,398
Breast Neoplasms 19 | 445
Mammary Neoplasms 19 | 425
colon cancer 19 | 1,478
diabetes mellitus 19 | 1,728
juvenile dermatomyositis 19 | 1,187
lung carcinoma 19 | 2,843
tuberculosis 19 | 2,010
ulcerative colitis 19 | 1,819
Cryptorchidism 18 | 296
Frontal bossing 18 | 157
Seizures 18 | 596
Stomach Neoplasms 18 | 300
astrocytoma 18 | 1,146
Epilepsy 17 | 792
Obesity 17 | 678
group 4 medulloblastoma 17 | 1,855
Cleft Palate 16 | 271
Lung Neoplasms 16 | 232
Muscle hypotonia 16 | 571
Rheumatoid arthritis 16 | 1,191
Blepharoptosis 15 | 231
Byzanthine arch palate 15 | 194
Downward slant of palpebral fissure 15 | 158
Strabismus 15 | 270
Adenoma 14 | 167
High forehead 14 | 102
Tall forehead 14 | 102
Ventricular Septal Defects 14 | 119
Acquired scoliosis 13 | 281
Big calvaria 13 | 147
Cleft Lip 13 | 141
Concave bridge of nose 13 | 195
Craniofacial Abnormalities 13 | 151
Curvature of spine 13 | 282
Depressed nasal bridge 13 | 195
Depressed nasal root/bridge 13 | 195
Increased head circumference 13 | 147
Increased size of cranium 13 | 147
Increased size of skull 13 | 147
Vascular disease 13 | 319
acute quadriplegic myopathy 13 | 1,158
adrenocortical carcinoma 13 | 1,428
Failure to gain weight 12 | 365
Heart disease 12 | 306
Liver cancer 12 | 604
Osteoporosis 12 | 363
Pediatric failure to thrive 12 | 365
acute myeloid leukemia 12 | 783
nasopharyngeal carcinoma 12 | 1,058

Tissue

Endocrine System 133 | 18,159
Digestive Tract 132 | 17,369
Female tissues 131 | 17,400
Nervous System 131 | 16,725
Skin and soft tissues 131 | 17,230
Male tissues 129 | 17,142
Urinary Tract 129 | 16,678
Blood and immune system 128 | 16,909
Liver and Pancreas 124 | 16,750
Respiratory system 119 | 16,393
Cardiovascular System 112 | 15,192

Target Family

Non-IDG 49 | 12,091
Transcription Factor 36 | 1,400
Kinase 33 | 634
GPCR 10 | 408
Enzyme 6 | 4,145
TF/Epigenetic 2 | 38
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

KEGG Pathway

Signaling pathways regulating ... 138 | 138
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Dual specificity protein phosphatase 9 DUSP9 Tbio Enzyme -1.15238 17.2 202
Polycomb group RING finger protein 1 PCGF1 Tbio Non-IDG -0.99091 11.4 101
Steroid hormone receptor ERR2 ESRRB Tchem Nuclear Receptor -1.95523 86.9 173
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
Polycomb group RING finger protein 3 PCGF3 Tdark Non-IDG -0.48328 1.97 115
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686