Development Level

Tchem 45 | 1,598
Tbio 33 | 11,445
Tclin 30 | 613
Tdark 6 | 6,588

Collection

Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 5 | 499
abnormal behavior 4 | 298
abnormal bone structure 4 | 187
decreased total body fat amoun... 4 | 207
increased circulating sodium l... 4 | 71
increased heart weight 4 | 62
increased startle reflex 4 | 112
decreased grip strength 3 | 116
hyperactivity 3 | 148
small superior vagus ganglion 3 | 74
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
abnormal gait 2 | 69
decreased bone mineral content 2 | 151
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
hydrometra 2 | 53
increased bone mineral content 2 | 108
increased circulating chloride... 2 | 41
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
male infertility 2 | 123
prenatal lethality 2 | 28
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal gallbladder morpholog... 1 | 1
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal placenta vasculature 1 | 2
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal tail length 1 | 3
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cyanosis 1 | 7
decreased anxiety-related resp... 1 | 12
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged spleen 1 | 41
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased grip strength 1 | 41
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
premature death 1 | 5
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
short tibia 1 | 97
small epididymis 1 | 3
small kidney 1 | 16

Disease

Carcinoma 88 | 11,493
glioblastoma 60 | 5,792
psoriasis 57 | 6,694
ovarian cancer 56 | 8,520
medulloblastoma, large-cell 55 | 6,241
Schizophrenia 49 | 1,160
atypical teratoid / rhabdoid tumor 45 | 5,112
ependymoma 45 | 4,679
osteosarcoma 41 | 7,950
group 3 medulloblastoma 39 | 4,104
adult high grade glioma 37 | 3,801
Breast cancer 36 | 3,578
lung cancer 36 | 4,740
lung carcinoma 36 | 2,843
Astrocytoma, Pilocytic 35 | 3,081
primitive neuroectodermal tumor 35 | 3,035
Bipolar Disorder 33 | 666
Depressive disorder 33 | 409
Kidney cancer 32 | 2,613
oligodendroglioma 31 | 2,850
Cancer 30 | 2,499
Major Depressive Disorder 27 | 301
Mental Depression 27 | 333
astrocytic glioma 25 | 2,597
lung adenocarcinoma 24 | 2,716
malignant mesothelioma 23 | 3,232
pancreatic cancer 23 | 2,398
subependymal giant cell astrocytoma 23 | 2,287
Epilepsy 22 | 792
Unipolar Depression 22 | 250
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
invasive ductal carcinoma 22 | 2,951
pituitary cancer 22 | 1,972
non-small cell lung cancer 21 | 2,890
Autistic Disorder 20 | 364
Mood Disorders 20 | 184
Pick disease 20 | 1,894
Intellectual disability 19 | 1,016
Obesity 19 | 678
Parkinson's disease 19 | 392
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Alcoholic Intoxication, Chronic 18 | 289
Migraine 18 | 83
interstitial cystitis 18 | 2,312
Alzheimer's disease 17 | 658
Alcohol dependence 16 | 107
colon cancer 16 | 1,478
diabetes mellitus 16 | 1,728
Attention deficit hyperactivity disorder 15 | 278
Hypertension 15 | 396
Melanoma 15 | 711
astrocytoma 15 | 1,146
group 4 medulloblastoma 15 | 1,855
ulcerative colitis 15 | 1,819
Liver cancer 13 | 604
Rheumatoid arthritis 13 | 1,191
Cognitive delay 12 | 608
Dull intelligence 12 | 645
Global developmental delay 12 | 608
Irritable bowel syndrome 12 | 60
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental and motor retardation 12 | 608
Mental deficiency 12 | 645
Poor school performance 12 | 645
Seizures 12 | 596
adrenocortical carcinoma 12 | 1,428
cystic fibrosis 12 | 1,696
Adenoma 11 | 167
Autosomal recessive predisposition 11 | 1,442
Diarrhea 11 | 253
Gastroesophageal reflux disease 11 | 110
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Constipation 10 | 181
Heart disease 10 | 306
Hypertensive disease 10 | 292
Pain agnosia 10 | 104
Psychotic Disorders 10 | 151
Skin cancer 10 | 469
Substance Withdrawal Syndrome 10 | 55
Substance abuse 10 | 59
active Crohn's disease 10 | 922
breast carcinoma 10 | 1,638
ductal carcinoma in situ 10 | 1,745
Asthma 9 | 385
Breast Neoplasms 9 | 445
Dementia 9 | 175
Hyperalgesia 9 | 83
Mammary Neoplasms 9 | 425
Short stature 9 | 531
Stomach Neoplasms 9 | 300
Toxic encephalopathy 9 | 141
juvenile dermatomyositis 9 | 1,187
substance-related disorder 9 | 162
tuberculosis 9 | 2,010
Atrial Fibrillation 8 | 124
Multiple myeloma 8 | 1,332
Prostatic Neoplasms 8 | 495
cutaneous lupus erythematosus 8 | 1,057

Tissue

Endocrine System 107 | 18,159
Digestive Tract 105 | 17,369
Blood and immune system 101 | 16,909
Female tissues 101 | 17,400
Nervous System 100 | 16,725
Skin and soft tissues 100 | 17,230
Male tissues 97 | 17,142
Liver and Pancreas 95 | 16,750
Urinary Tract 94 | 16,678
Respiratory system 93 | 16,393
Cardiovascular System 84 | 15,192

Target Family

Non-IDG 34 | 12,091
Enzyme 29 | 4,145
Ion Channel 24 | 344
GPCR 12 | 408
Kinase 12 | 634
Transporter 3 | 473

KEGG Pathway

Serotonergic synapse 114 | 114
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Gamma-aminobutyric acid receptor subunit beta-3 GABRB3 Tclin Ion Channel -2.13205 136.0 202
Cytosolic phospholipase A2 gamma PLA2G4C Tchem Enzyme -1.27690 20.9 63
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492