Development Level

Tbio 56 | 11,445
Tchem 20 | 1,598
Tclin 4 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
decreased circulating serum al... 3 | 82
decreased lymphocyte cell numb... 3 | 83
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
increased leukocyte cell numbe... 3 | 47
increased neutrophil cell numb... 3 | 46
preweaning lethality, incomple... 3 | 499
abnormal cornea morphology 2 | 31
abnormal lung morphology 2 | 26
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
decreased body weight 2 | 161
decreased circulating fructosa... 2 | 30
decreased circulating sodium l... 2 | 22
decreased eosinophil cell numb... 2 | 24
decreased hematocrit 2 | 46
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased circulating alkaline... 2 | 122
increased erythrocyte cell num... 2 | 39
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal stomach morphology 1 | 10
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased circulating unsatura... 1 | 2
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
fused cornea and lens 1 | 5
fusion of vertebral arches 1 | 7
hemorrhage 1 | 23
hyperactivity 1 | 148
increased circulating amylase ... 1 | 25
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
pallor 1 | 34
prolonged PR interval 1 | 15
short tibia 1 | 97
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

ovarian cancer 48 | 8,520
Carcinoma 46 | 11,493
psoriasis 44 | 6,694
glioblastoma 41 | 5,792
osteosarcoma 38 | 7,950
Cancer 36 | 2,499
lung cancer 31 | 4,740
tuberculosis 31 | 2,010
atypical teratoid / rhabdoid tumor 29 | 5,112
lung carcinoma 27 | 2,843
adult high grade glioma 26 | 3,801
Astrocytoma, Pilocytic 25 | 3,081
malignant mesothelioma 25 | 3,232
medulloblastoma, large-cell 25 | 6,241
ependymoma 24 | 4,679
diabetes mellitus 22 | 1,728
Arthritis 20 | 290
Breast cancer 20 | 3,578
Schizophrenia 20 | 1,160
pancreatic cancer 20 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
Asthma 18 | 385
Vascular disease 18 | 319
astrocytoma 18 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
Inflammatory bowel disease 17 | 151
Kidney disease 17 | 430
Lung disease 17 | 142
Multiple Sclerosis 17 | 540
subependymal giant cell astrocytoma 17 | 2,287
lung adenocarcinoma 16 | 2,716
non-small cell lung cancer 16 | 2,890
Kidney cancer 15 | 2,613
Liver Cirrhosis, Experimental 15 | 769
Reperfusion Injury 15 | 86
Rheumatoid arthritis 15 | 1,191
interstitial cystitis 15 | 2,312
invasive ductal carcinoma 15 | 2,951
Breast Neoplasms 14 | 445
Hypertension 14 | 396
Pneumonia 14 | 174
cystic fibrosis 14 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
ulcerative colitis 14 | 1,819
Brain Ischemia 13 | 110
Inflammation 13 | 120
Mammary Neoplasms 13 | 425
Multiple myeloma 13 | 1,332
Obesity 13 | 678
cutaneous lupus erythematosus 13 | 1,057
group 3 medulloblastoma 13 | 4,104
Dermatitis 12 | 157
Influenza 12 | 142
Lung Neoplasms 12 | 232
colon cancer 12 | 1,478
esophageal adenocarcinoma 12 | 737
group 4 medulloblastoma 12 | 1,855
Cell Transformation, Neoplastic 11 | 97
Cholestasis, Extrahepatic 11 | 25
Depressive disorder 11 | 409
Eye disease 11 | 62
Heart disease 11 | 306
Hypersensitivity reaction type II disease 11 | 253
Mental Depression 11 | 333
juvenile dermatomyositis 11 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
primitive neuroectodermal tumor 11 | 3,035
Alzheimer's disease 10 | 658
Atherosclerosis 10 | 291
Bipolar Disorder 10 | 666
Hyperalgesia 10 | 83
Hypertensive disease 10 | 292
Liver disease 10 | 237
Myocardial Ischemia 10 | 169
Neoplastic Cell Transformation 10 | 89
Peritonitis 10 | 43
Waldenstrons macroglobulinemia 10 | 765
astrocytic glioma 10 | 2,597
hepatocellular carcinoma 10 | 547
oligodendroglioma 10 | 2,850
periodontitis 10 | 293
Allergic hypersensitivity disease 9 | 126
Carcinoma, Hepatocellular 9 | 228
Cholestasis 9 | 155
Intellectual disability 9 | 1,016
Liver carcinoma 9 | 240
Malaria 9 | 160
Neoplasm Invasiveness 9 | 161
Neurodegenerative disease 9 | 414
Salmonellosis 9 | 42
gastric cancer 9 | 459
spina bifida 9 | 1,074
Diarrhea 8 | 253
Leishmaniasis 8 | 47
Neuropathy 8 | 261
Pick disease 8 | 1,894
Stomach Neoplasms 8 | 300
adrenocortical carcinoma 8 | 1,428
breast carcinoma 8 | 1,638
pediatric high grade glioma 8 | 1,064

Tissue

Endocrine System 84 | 18,159
Urinary Tract 84 | 16,678
Blood and immune system 83 | 16,909
Digestive Tract 83 | 17,369
Female tissues 83 | 17,400
Liver and Pancreas 83 | 16,750
Male tissues 83 | 17,142
Skin and soft tissues 83 | 17,230
Respiratory system 82 | 16,393
Nervous System 81 | 16,725
Cardiovascular System 79 | 15,192

Target Family

Non-IDG 59 | 12,091
Kinase 14 | 634
Enzyme 7 | 4,145
Transcription Factor 4 | 1,400

KEGG Pathway

Salmonella infection 84 | 84
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-C motif chemokine 3-like 1 CCL3L1 Tbio Non-IDG -1.80717 51.3 142
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
Cytoplasmic dynein 1 light intermediate chain 2 DYNC1LI2 Tbio Non-IDG -0.61455 3.87 95
Wiskott-Aldrich syndrome protein family member 2 WASF2 Tbio Non-IDG -2.90666 762.6 254
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.66545 435.4 248
Pleckstrin homology domain-containing family M member 2 PLEKHM2 Tbio Non-IDG -0.32760 3.56 65
Lipopolysaccharide-binding protein LBP Tbio Non-IDG -2.61682 357.2 225
Profilin-1 PFN1 Tbio Non-IDG -2.31736 223.5 260
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380