Development Level

Tbio 32 | 11,651
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased circulating insulin ... 3 | 76
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
decreased circulating glucose ... 2 | 126
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal response to new envir... 1 | 10
abnormal response to tactile s... 1 | 17
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
alopecia 1 | 1
decreased IgE level 1 | 6
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating lactate ... 1 | 3
decreased fasted circulating g... 1 | 65
decreased large unstained cell... 1 | 11
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased exploration in new e... 1 | 8
increased grip strength 1 | 41
increased heart rate 1 | 23
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 36
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
long tibia 1 | 25
mammalian phenotype 1 | 17
small thymus 1 | 16
tremors 1 | 39
trunk curl 1 | 16

Disease

ovarian cancer 21 | 8,520
osteosarcoma 18 | 7,950
medulloblastoma, large-cell 16 | 6,241
psoriasis 15 | 6,694
glioblastoma 12 | 5,792
Carcinoma 10 | 11,493
Hypomyelinating leukodystrophy 6 10 | 26
ependymoma 10 | 4,679
atypical teratoid / rhabdoid tumor 9 | 5,112
Astrocytoma, Pilocytic 8 | 3,081
Tetanus 8 | 68
group 3 medulloblastoma 8 | 4,104
group 4 medulloblastoma 8 | 1,855
lung cancer 8 | 4,740
tuberculosis 8 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
malignant mesothelioma 7 | 3,232
Pick disease 6 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Multiple myeloma 5 | 1,332
Schizophrenia 5 | 1,160
Vici syndrome 5 | 14
adult high grade glioma 5 | 3,801
astrocytic glioma 5 | 2,597
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non-small cell lung cancer 5 | 2,890
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
gastric cancer 4 | 459
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
non primary Sjogren syndrome sicca 4 | 891
pancreatic cancer 4 | 2,398
pancreatic carcinoma 4 | 562
Alzheimer's disease 3 | 658
Autosomal recessive predisposition 3 | 1,442
Cataract 8 multiple types 3 | 33
Diarrhea 3 | 253
Gaucher disease type 1 3 | 180
acute quadriplegic myopathy 3 | 1,158
juvenile dermatomyositis 3 | 1,187
primitive neuroectodermal tumor 3 | 3,035
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
subependymal giant cell astrocytoma 3 | 2,287
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Anemia 2 | 365
Batten disease 2 | 13
Bipolar Disorder 2 | 666
Botulism 2 | 24
Cerebellar Ataxia 2 | 304
Colitis 2 | 54
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Down syndrome 2 | 499
Dysarthria 2 | 192
Epilepsy 2 | 792
Familial hemophagocytic lymphohistiocytosis 4 2 | 2
Gastroenteritis 2 | 41
Heart disease 2 | 306
Hemolytic-Uremic Syndrome 2 | 30
Kidney Failure 2 | 111
Liver Cirrhosis, Experimental 2 | 769
MAJOR AFFECTIVE DISORDER 2 2 | 22
Male infertility 2 | 206
Multiple Sclerosis 2 | 540
Osteogenesis imperfecta type 15 2 | 3
Osteoporosis 2 | 363
Pancreatic agenesis 2 | 17
Reflex, Deep Tendon, Absent 2 | 92
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
axial spondyloarthropathy 2 | 28
breast carcinoma 2 | 1,638
diabetes mellitus 2 | 1,728
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Defective enamel matrix 1 | 35
Delayed Puberty 1 | 97
Gonadal Dysgenesis 1 | 28
Gonadal Dysgenesis, Mixed 1 | 19
Human granulocytic anaplasmosis 1 | 7
Low serum estradiol levels 1 | 22
Primary hypogonadism 1 | 37
Primary physiologic amenorrhea 1 | 55
Progressive microcephaly 1 | 32
Pure gonadal dysgenesis 1 | 19
Sparse pubic hair 1 | 31
Streak ovary 1 | 15

Tissue

Blood and immune system 34 | 16,909
Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Respiratory system 34 | 16,393
Skin and soft tissues 34 | 17,230
Urinary Tract 34 | 16,678
Cardiovascular System 33 | 15,192

Target Family

Non-IDG 34 | 12,091

KEGG Pathway

SNARE interactions in vesicula... 34 | 34
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
BET1-like protein BET1L Tbio Non-IDG -0.07918 0.87 16
Vesicle transport protein USE1 USE1 Tbio Non-IDG -2.63368 401.2 166
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.53335 323.7 203
Syntaxin-1B STX1B Tbio Non-IDG -1.76579 55.3 27
Synaptosomal-associated protein 29 SNAP29 Tbio Non-IDG -1.47467 28.0 125
Syntaxin-4 STX4 Tbio Non-IDG -1.95295 84.2 207
Synaptobrevin homolog YKT6 YKT6 Tbio Non-IDG -1.58852 39.0 37
Syntaxin-6 STX6 Tbio Non-IDG -1.77339 56.6 215
Syntaxin-7 STX7 Tbio Non-IDG -1.28658 20.5 108