Development Level

Tclin 72 | 613
Tbio 37 | 11,445
Tchem 33 | 1,598
Tdark 6 | 6,588

Collection

RFA-RM-18-021 5 | 328
Ion Channel: IDG Consortium (T... 4 | 99
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 12 | 979
abnormal behavior 8 | 298
hyperactivity 5 | 148
preweaning lethality, incomple... 5 | 499
decreased vertical activity 4 | 208
abnormal embryo size 3 | 220
decreased bone mineral content 3 | 151
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased fasted circulating g... 2 | 65
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hemorrhage 2 | 23
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
small superior vagus ganglion 2 | 74
abnormal allantois morphology 1 | 8
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal gallbladder morpholog... 1 | 1
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal neural tube morpholog... 1 | 12
abnormal placenta vasculature 1 | 2
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased brain size 1 | 4
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired righting response 1 | 26
increased circulating alanine ... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
small epididymis 1 | 3
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small testis 1 | 58
small thymus 1 | 16

Disease

Carcinoma 85 | 11,493
glioblastoma 72 | 5,792
ovarian cancer 72 | 8,520
medulloblastoma, large-cell 70 | 6,241
atypical teratoid / rhabdoid tumor 63 | 5,112
ependymoma 62 | 4,679
psoriasis 56 | 6,694
adult high grade glioma 55 | 3,801
osteosarcoma 51 | 7,950
Epilepsy 49 | 792
primitive neuroectodermal tumor 48 | 3,035
Diabetes mellitus type 2 46 | 69
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
astrocytic glioma 45 | 2,597
group 3 medulloblastoma 45 | 4,104
Astrocytoma, Pilocytic 44 | 3,081
oligodendroglioma 43 | 2,850
Schizophrenia 41 | 1,160
lung carcinoma 38 | 2,843
Kidney cancer 37 | 2,613
subependymal giant cell astrocytoma 37 | 2,287
lung cancer 35 | 4,740
Bipolar Disorder 33 | 666
Breast cancer 33 | 3,578
Mitochondrial complex I deficiency 29 | 46
Pick disease 28 | 1,894
Multiple myeloma 27 | 1,332
Cerebellar Ataxia 26 | 304
Leigh disease 24 | 100
Autosomal recessive predisposition 23 | 1,442
Depressive disorder 23 | 409
Intellectual disability 23 | 1,016
Seizures 23 | 596
Anxiety 22 | 136
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Mental and motor retardation 22 | 608
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
pituitary cancer 22 | 1,972
General anesthesia 20 | 53
Muscle hypotonia 20 | 571
Tonic-clonic epilepsy 20 | 47
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
invasive ductal carcinoma 20 | 2,951
lung adenocarcinoma 20 | 2,716
Alcoholic Intoxication, Chronic 19 | 289
Blepharoptosis 19 | 231
Hyperreflexia 19 | 209
Mitochondrial Complex 1 Deficiency 19 | 28
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
non-small cell lung cancer 19 | 2,890
Acidosis, Lactic 18 | 97
Autistic Disorder 18 | 364
Lactic acidemia 18 | 95
Nystagmus 18 | 317
Sensorineural Hearing Loss (disorder) 18 | 284
Failure to gain weight 17 | 365
Major Depressive Disorder 17 | 301
Mental Depression 17 | 333
Pediatric failure to thrive 17 | 365
Strabismus 17 | 270
pancreatic cancer 17 | 2,398
Dystonia 16 | 164
Insomnia 16 | 20
Muscle Spasticity 16 | 195
Muscle Weakness 16 | 170
NADH:Q(1) Oxidoreductase deficiency 16 | 24
Parkinson's disease 16 | 392
Unipolar Depression 16 | 250
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Obesity 15 | 678
Poor school performance 15 | 645
diabetes mellitus 15 | 1,728
interstitial cystitis 15 | 2,312
malignant mesothelioma 15 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
ulcerative colitis 15 | 1,819
Abnormal mitochondria in muscle tissue 14 | 20
CSF lactate increased 14 | 33
Cancer 14 | 2,499
Developmental regression 14 | 95
Dystonic disease 14 | 106
Highly variable clinical phenotype 14 | 150
Highly variable phenotype and severity 14 | 150
Highly variable phenotype, even within families 14 | 150
Leigh syndrome 14 | 28
Loss of developmental milestones 14 | 95
Mental deterioration in childhood 14 | 95
Neurodevelopmental regression 14 | 95
Phenotypic variability 14 | 150
Psychomotor regression 14 | 95
Psychomotor regression beginning in infancy 14 | 95
Psychomotor regression in infants 14 | 95
Psychomotor regression, progressive 14 | 95
Respiratory Failure 14 | 104
astrocytoma 14 | 1,146
group 4 medulloblastoma 14 | 1,855

Tissue

Endocrine System 147 | 18,159
Nervous System 144 | 16,725
Female tissues 139 | 17,400
Digestive Tract 138 | 17,369
Skin and soft tissues 138 | 17,230
Male tissues 137 | 17,142
Blood and immune system 136 | 16,909
Urinary Tract 132 | 16,678
Liver and Pancreas 130 | 16,750
Respiratory system 127 | 16,393
Cardiovascular System 124 | 15,192

Target Family

Enzyme 66 | 4,145
Ion Channel 36 | 344
Non-IDG 24 | 12,091
Kinase 15 | 634
Transporter 4 | 473
GPCR 3 | 408

KEGG Pathway

Retrograde endocannabinoid sig... 148 | 148
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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