Development Level

Tchem 34 | 1,388
Tbio 26 | 11,651
Tclin 8 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased body weight 3 | 161
abnormal heart morphology 2 | 162
abnormal testis morphology 2 | 43
decreased circulating creatini... 2 | 39
increased circulating alkaline... 2 | 122
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased caudal vertebrae num... 1 | 7
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Cancer 56 | 2,499
Carcinoma 55 | 11,493
ovarian cancer 53 | 8,520
osteosarcoma 40 | 7,950
glioblastoma 34 | 5,792
lung cancer 34 | 4,740
medulloblastoma, large-cell 33 | 6,241
atypical teratoid / rhabdoid tumor 31 | 5,112
Breast cancer 30 | 3,578
psoriasis 29 | 6,694
ependymoma 27 | 4,679
oligodendroglioma 22 | 2,850
Kidney cancer 21 | 2,613
Byzanthine arch palate 20 | 194
Short stature 19 | 531
adult high grade glioma 19 | 3,801
astrocytic glioma 19 | 2,597
malignant mesothelioma 19 | 3,232
pancreatic cancer 19 | 2,398
Acquired scoliosis 17 | 281
Curvature of spine 17 | 282
Renal Cell Carcinoma 17 | 214
group 3 medulloblastoma 17 | 4,104
Blepharoptosis 16 | 231
Epilepsy 16 | 792
Intellectual disability 16 | 1,016
Muscle hypotonia 16 | 571
Orbital separation excessive 16 | 244
Schizophrenia 16 | 1,160
Seizures 16 | 596
invasive ductal carcinoma 16 | 2,951
Cognitive delay 15 | 608
Dull intelligence 15 | 645
Global developmental delay 15 | 608
Hypoplastic mandible condyle 15 | 275
Low intelligence 15 | 645
Mandibular hypoplasia 15 | 275
Mental Retardation 15 | 645
Mental and motor retardation 15 | 608
Mental deficiency 15 | 645
Micrognathism 15 | 275
Poor school performance 15 | 645
Strabismus 15 | 270
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
non-small cell lung cancer 15 | 2,890
Astrocytoma, Pilocytic 14 | 3,081
Downward slant of palpebral fissure 14 | 158
Pectus excavatum 14 | 100
group 4 medulloblastoma 14 | 1,855
juvenile dermatomyositis 14 | 1,187
ulcerative colitis 14 | 1,819
Carcinoma, Squamous Cell 13 | 110
Cryptorchidism 13 | 296
Hemangioma 13 | 69
Lung Neoplasms 13 | 232
Multiple myeloma 13 | 1,332
Prostatic Neoplasms 13 | 495
Squamous cell carcinoma 13 | 129
diabetes mellitus 13 | 1,728
lung adenocarcinoma 13 | 2,716
subependymal giant cell astrocytoma 13 | 2,287
Breast Neoplasms 12 | 445
Carcinoma, Hepatocellular 12 | 228
Concave bridge of nose 12 | 195
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Frontal bossing 12 | 157
High forehead 12 | 102
Joint hyperflexibility 12 | 78
Liver carcinoma 12 | 240
Mammary Neoplasms 12 | 425
Stomach Neoplasms 12 | 300
Tall forehead 12 | 102
breast carcinoma 12 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
primitive neuroectodermal tumor 12 | 3,035
tuberculosis 12 | 2,010
Congenital Epicanthus 11 | 177
Delayed bone age 11 | 136
Exophthalmos 11 | 112
Feeding difficulties in infancy 11 | 175
Low posterior hairline 11 | 52
Noonan syndrome 11 | 34
Prominent eyes 11 | 96
Prominent globes 11 | 96
Protruding eyes 11 | 96
Small head 11 | 374
Ventricular Septal Defects 11 | 119
astrocytoma 11 | 1,146
lung carcinoma 11 | 2,843
Failure to gain weight 10 | 365
Hepatomegaly 10 | 285
Liver neoplasms 10 | 130
Melanoma 10 | 711
Myopia 10 | 176
Pediatric failure to thrive 10 | 365
cystic fibrosis 10 | 1,696
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
primary pancreatic ductal adenocarcinoma 10 | 1,109

Tissue

Cardiovascular System 68 | 15,192
Digestive Tract 68 | 17,369
Endocrine System 68 | 18,159
Female tissues 68 | 17,400
Liver and Pancreas 68 | 16,750
Male tissues 68 | 17,142
Nervous System 68 | 16,725
Respiratory system 68 | 16,393
Skin and soft tissues 68 | 17,230
Urinary Tract 68 | 16,678
Blood and immune system 67 | 16,909

Target Family

Non-IDG 23 | 12,091
Kinase 21 | 634
Enzyme 15 | 4,145
Transcription Factor 6 | 1,400
Epigenetic 2 | 242
Transporter 1 | 473

KEGG Pathway

Renal cell carcinoma 68 | 68
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Endothelial PAS domain-containing protein 1 EPAS1 Tchem Non-IDG -2.29071 180.5 477
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Protransforming growth factor alpha TGFA Tbio Non-IDG -2.15761 135.3 697
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Hepatocyte growth factor HGF Tchem Enzyme -3.30841 2392.1 724
Aryl hydrocarbon receptor nuclear translocator ARNT Tbio Transcription Factor -2.53687 261.2 474
Platelet-derived growth factor subunit B PDGFB Tchem Non-IDG -3.27151 1795.5 434
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Cullin-2 CUL2 Tbio Non-IDG -1.99844 95.1 373