Development Level

Tbio 75 | 11,445
Tchem 44 | 1,598
Tclin 10 | 613
Tdark 4 | 6,588

Collection

GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

decreased total body fat amoun... 7 | 207
preweaning lethality, incomple... 7 | 499
increased circulating alkaline... 6 | 122
preweaning lethality, complete... 6 | 979
abnormal behavior 5 | 298
increased heart weight 5 | 62
increased startle reflex 5 | 112
abnormal bone structure 4 | 187
decreased body weight 4 | 161
decreased circulating creatini... 3 | 39
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased fasted circulating g... 2 | 65
decreased vertical activity 2 | 208
hyperactivity 2 | 148
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
short tibia 2 | 97
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased IgE level 1 | 6
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased pulmonary respirator... 1 | 5
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating lipase l... 1 | 3
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small kidney 1 | 16
small testis 1 | 58
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

Carcinoma 97 | 11,493
ovarian cancer 84 | 8,520
glioblastoma 73 | 5,792
Cancer 62 | 2,499
osteosarcoma 62 | 7,950
medulloblastoma, large-cell 60 | 6,241
psoriasis 60 | 6,694
atypical teratoid / rhabdoid tumor 59 | 5,112
lung cancer 58 | 4,740
ependymoma 53 | 4,679
Breast cancer 49 | 3,578
group 3 medulloblastoma 46 | 4,104
adult high grade glioma 43 | 3,801
Kidney cancer 42 | 2,613
Astrocytoma, Pilocytic 41 | 3,081
primitive neuroectodermal tumor 40 | 3,035
invasive ductal carcinoma 37 | 2,951
lung carcinoma 35 | 2,843
lung adenocarcinoma 33 | 2,716
malignant mesothelioma 33 | 3,232
non-small cell lung cancer 33 | 2,890
pancreatic cancer 33 | 2,398
Schizophrenia 32 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
oligodendroglioma 30 | 2,850
pituitary cancer 29 | 1,972
subependymal giant cell astrocytoma 29 | 2,287
diabetes mellitus 28 | 1,728
ulcerative colitis 28 | 1,819
breast carcinoma 27 | 1,638
Kidney disease 26 | 430
Pick disease 26 | 1,894
interstitial cystitis 26 | 2,312
astrocytic glioma 25 | 2,597
ductal carcinoma in situ 25 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
juvenile dermatomyositis 24 | 1,187
Breast Neoplasms 23 | 445
Hypertensive disease 23 | 292
Liver Cirrhosis, Experimental 23 | 769
Mammary Neoplasms 23 | 425
Depressive disorder 22 | 409
group 4 medulloblastoma 22 | 1,855
cystic fibrosis 21 | 1,696
Epilepsy 20 | 792
Autosomal recessive predisposition 19 | 1,442
Hypertension 19 | 396
astrocytoma 19 | 1,146
colon cancer 19 | 1,478
tuberculosis 19 | 2,010
Obesity 18 | 678
Seizures 18 | 596
Vascular disease 18 | 319
Acquired scoliosis 17 | 281
Curvature of spine 17 | 282
Heart disease 17 | 306
Hypoplastic mandible condyle 17 | 275
Intellectual disability 17 | 1,016
Mandibular hypoplasia 17 | 275
Micrognathism 17 | 275
Orbital separation excessive 17 | 244
Short stature 17 | 531
adrenocortical carcinoma 17 | 1,428
Arthritis 16 | 290
Bipolar Disorder 16 | 666
Liver Cirrhosis 16 | 181
Lung Neoplasms 16 | 232
Mental Depression 16 | 333
Prostatic Neoplasms 16 | 495
Rheumatoid arthritis 16 | 1,191
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Dull intelligence 15 | 645
Low intelligence 15 | 645
Melanoma 15 | 711
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
dermatomyositis 15 | 966
Cognitive delay 14 | 608
Cryptorchidism 14 | 296
Global developmental delay 14 | 608
Lung disease 14 | 142
Mental and motor retardation 14 | 608
Multiple myeloma 14 | 1,332
Muscle hypotonia 14 | 571
Osteoporosis 14 | 363
Substance Withdrawal Syndrome 14 | 55
primary pancreatic ductal adenocarcinoma 14 | 1,109
Alzheimer's disease 13 | 658
Asthma 13 | 385
Byzanthine arch palate 13 | 194
Cholestasis, Extrahepatic 13 | 25
Duchenne muscular dystrophy 13 | 601
Liver cancer 13 | 604
active Crohn's disease 13 | 922
nasopharyngeal carcinoma 13 | 1,058
Diabetes Mellitus, Non-Insulin-Dependent 12 | 145
acute quadriplegic myopathy 12 | 1,158
cutaneous lupus erythematosus 12 | 1,057

Tissue

Endocrine System 129 | 18,159
Blood and immune system 127 | 16,909
Digestive Tract 126 | 17,369
Female tissues 125 | 17,400
Male tissues 125 | 17,142
Urinary Tract 124 | 16,678
Skin and soft tissues 123 | 17,230
Nervous System 122 | 16,725
Respiratory system 122 | 16,393
Liver and Pancreas 121 | 16,750
Cardiovascular System 117 | 15,192

Target Family

Non-IDG 57 | 12,091
Kinase 30 | 634
Enzyme 25 | 4,145
Transcription Factor 16 | 1,400
GPCR 5 | 408

KEGG Pathway

Relaxin signaling pathway 133 | 133
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Collagen alpha-1(IV) chain COL4A1 Tbio Non-IDG -2.28595 186.9 391