Development Level

Tbio 122 | 10,625
Tchem 53 | 1,890
Tclin 30 | 602
Tdark 8 | 7,003

Collection

Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 15 | 633
preweaning lethality, incomple... 8 | 260
abnormal retina morphology 5 | 100
decreased body weight 5 | 174
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased bone mineral content 4 | 157
decreased circulating fructosa... 4 | 31
decreased total body fat amoun... 4 | 186
abnormal behavior 3 | 226
decreased leukocyte cell numbe... 3 | 54
abnormal bone structure 2 | 131
abnormal response to tactile s... 2 | 16
cataract 2 | 26
decreased NK T cell number 2 | 28
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 53
decreased circulating creatini... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased kidney weight 2 | 7
decreased lean body mass 2 | 195
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
impaired pupillary reflex 2 | 14
increased blood urea nitrogen ... 2 | 44
increased circulating alkaline... 2 | 119
increased circulating free fat... 2 | 17
increased circulating triglyce... 2 | 24
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
tremors 2 | 34
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal startle reflex 1 | 14
abnormal vibrissa morphology 1 | 17
cleft palate 1 | 6
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased IgE level 1 | 3
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased spleen weight 1 | 13
edema 1 | 11
embryonic growth retardation 1 | 28
female infertility 1 | 34
hemorrhage 1 | 12
hydrops fetalis 1 | 22
hypoactivity 1 | 89
impaired righting response 1 | 19
increased CD4-positive, alpha ... 1 | 15
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating amylase ... 1 | 13
increased circulating calcium ... 1 | 32
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased red blood cell distr... 1 | 21
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
long tibia 1 | 13
mydriasis 1 | 9
narrow eye opening 1 | 15
pallor 1 | 13
prenatal lethality prior to he... 1 | 64
vertebral fusion 1 | 23

Disease

osteosarcoma 123 | 7,933
ovarian cancer 121 | 8,492
glioblastoma 100 | 5,572
Cancer 93 | 2,346
medulloblastoma, large-cell 86 | 6,234
psoriasis 81 | 6,685
lung cancer 68 | 4,473
atypical teratoid / rhabdoid tumor 67 | 4,369
Breast cancer 62 | 3,099
pilocytic astrocytoma 62 | 3,086
invasive ductal carcinoma 57 | 2,950
Carcinoma 56 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
pediatric high grade glioma 54 | 2,712
lung carcinoma 53 | 2,844
malignant mesothelioma 50 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,956
oligodendroglioma 47 | 2,849
non-small cell lung cancer 45 | 2,798
pancreatic cancer 44 | 2,300
primitive neuroectodermal tumor 44 | 3,031
ependymoma 43 | 2,514
interstitial cystitis 43 | 2,299
subependymal giant cell astrocytoma 42 | 2,287
ulcerative colitis 38 | 2,087
lung adenocarcinoma 37 | 2,714
cystic fibrosis 36 | 1,670
diabetes mellitus 36 | 1,663
tuberculosis 36 | 1,563
primary pancreatic ductal adenocarcinoma 35 | 1,271
medulloblastoma 33 | 1,524
ductal carcinoma in situ 32 | 1,745
astrocytic glioma 31 | 2,241
astrocytoma 31 | 1,493
breast carcinoma 31 | 1,614
group 3 medulloblastoma 31 | 2,254
colon cancer 29 | 1,475
juvenile dermatomyositis 29 | 1,189
group 4 medulloblastoma 28 | 1,875
adult high grade glioma 25 | 2,148
Pick disease 24 | 1,893
Rheumatoid Arthritis 23 | 1,171
acute quadriplegic myopathy 23 | 1,157
posterior fossa group A ependymoma 22 | 1,511
Duchenne muscular dystrophy 21 | 602
Multiple myeloma 21 | 1,328
pituitary cancer 21 | 1,972
spina bifida 21 | 1,064
Waldenstrons macroglobulinemia 20 | 765
adrenocortical carcinoma 19 | 1,427
cutaneous lupus erythematosus 19 | 1,056
Mammary Neoplasms 18 | 410
dermatomyositis 18 | 967
primary Sjogren syndrome 18 | 789
Prostatic Neoplasms 17 | 471
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
Intellectual disability 16 | 573
Liver carcinoma 16 | 217
Neoplasm Invasiveness 16 | 127
gastric carcinoma 16 | 832
non-small cell lung carcinoma 16 | 413
IGA Glomerulonephritis 15 | 454
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
esophageal adenocarcinoma 15 | 737
Kidney disease 14 | 397
Vascular disease 14 | 281
posterior fossa group B ependymoma 14 | 1,530
Lung Neoplasms 13 | 171
Renal Cell Carcinoma 13 | 199
Schizophrenia 13 | 503
atypical teratoid/rhabdoid tumor 13 | 1,095
pancreatic carcinoma 13 | 567
Cleft palate 12 | 125
Down syndrome 12 | 548
Parkinson's disease 12 | 364
Stomach Neoplasms 12 | 282
Animal Mammary Neoplasms 11 | 136
Atherosclerosis 11 | 275
Neoplasm Metastasis 11 | 138
Noonan Syndrome 11 | 33
nasopharyngeal carcinoma 11 | 1,056
Alzheimer's disease 10 | 644
Amyotrophic Lateral Sclerosis 10 | 432
Asthma 10 | 349
Atopic dermatitis 10 | 944
Becker muscular dystrophy 10 | 187
Gliosis 10 | 16
Heart disease 10 | 279
Hypertension 10 | 293
Hypertrophic Cardiomyopathy 10 | 56
Liver Cirrhosis 10 | 101
Mammary Neoplasms, Experimental 10 | 150
Squamous cell carcinoma 10 | 96
active ulcerative colitis 10 | 477
mucosa-associated lymphoid tissue lymphoma 10 | 480
Endometriosis 9 | 535
aldosterone-producing adenoma 9 | 664
gastric cancer 9 | 436
sonic hedgehog group medulloblastoma 9 | 1,482

Tissue

Endocrine System 213 | 18,512
Female tissues 213 | 18,647
Liver and Pancreas 212 | 18,136
Nervous System 212 | 18,561
Digestive Tract 211 | 18,473
Skin and soft tissues 211 | 18,115
Urinary Tract 211 | 18,444
Blood and immune system 210 | 17,995
Cardiovascular System 208 | 17,958
Male tissues 208 | 17,969
Respiratory system 205 | 17,484

Target Family

Non-IDG 131 | 11,969
Kinase 44 | 634
Enzyme 29 | 4,146
GPCR 8 | 408
Transporter 1 | 473

KEGG Pathway

Regulation of actin cytoskelet... 213 | 213
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha PIP5K1A Tbio Kinase -0.55632 4.98 106
Myosin regulatory light chain 2, atrial isoform MYL7 Tdark Non-IDG -0.73268 3.55 109
Wiskott-Aldrich syndrome protein WAS Tbio Non-IDG -3.08376 1138.7 279
Ras-related C3 botulinum toxin substrate 2 RAC2 Tchem Enzyme -2.87547 633.7 216
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.04744 808.6 1868
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.59105 344.4 405
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.89186 64.6 443
Paxillin PXN Tchem Non-IDG -2.97313 849.9 1088
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.78476 58.3 173