Development Level

Tbio 134 | 11,651
Tchem 35 | 1,388
Tclin 31 | 612
Tdark 7 | 6,593

Collection

Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 25 | 979
preweaning lethality, incomple... 12 | 499
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
embryonic lethality prior to t... 6 | 278
embryonic growth retardation 5 | 106
abnormal behavior 4 | 298
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased mean corpuscular vol... 4 | 79
decreased total body fat amoun... 4 | 207
edema 4 | 59
abnormal cornea morphology 3 | 31
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased circulating fructosa... 3 | 30
decreased circulating serum al... 3 | 82
decreased hematocrit 3 | 46
hemorrhage 3 | 23
increased circulating triglyce... 3 | 42
short tibia 3 | 97
abnormal lens morphology 2 | 81
abnormal pericardium morpholog... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
corneal opacity 2 | 32
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased spleen weight 2 | 10
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
fused cornea and lens 2 | 5
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 36
increased mean corpuscular vol... 2 | 92
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal locomotor activation 1 | 16
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal sensory capabilities-... 1 | 8
abnormal skin coloration 1 | 25
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
long tibia 1 | 25
prenatal lethality 1 | 28
thin ventricular wall 1 | 24
unresponsive to tactile stimul... 1 | 8
vertebral fusion 1 | 23

Disease

Carcinoma 150 | 11,493
osteosarcoma 120 | 7,950
ovarian cancer 118 | 8,520
glioblastoma 101 | 5,792
Cancer 96 | 2,499
medulloblastoma, large-cell 83 | 6,241
psoriasis 81 | 6,694
atypical teratoid / rhabdoid tumor 74 | 5,112
lung cancer 74 | 4,740
Breast cancer 67 | 3,578
ependymoma 65 | 4,679
Kidney cancer 57 | 2,613
Astrocytoma, Pilocytic 56 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,291
adult high grade glioma 55 | 3,801
invasive ductal carcinoma 54 | 2,951
malignant mesothelioma 51 | 3,232
lung carcinoma 49 | 2,843
group 3 medulloblastoma 48 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,955
pancreatic cancer 46 | 2,398
non-small cell lung cancer 45 | 2,890
oligodendroglioma 44 | 2,850
interstitial cystitis 41 | 2,312
primitive neuroectodermal tumor 41 | 3,035
astrocytic glioma 38 | 2,597
subependymal giant cell astrocytoma 38 | 2,287
tuberculosis 38 | 2,010
cystic fibrosis 36 | 1,696
diabetes mellitus 36 | 1,728
lung adenocarcinoma 36 | 2,716
group 4 medulloblastoma 35 | 1,855
breast carcinoma 33 | 1,638
ulcerative colitis 33 | 1,819
Schizophrenia 32 | 1,160
ductal carcinoma in situ 32 | 1,745
primary pancreatic ductal adenocarcinoma 30 | 1,109
Autosomal recessive predisposition 29 | 1,442
juvenile dermatomyositis 29 | 1,187
colon cancer 28 | 1,478
Intellectual disability 26 | 1,016
Liver Cirrhosis, Experimental 25 | 769
Rheumatoid arthritis 24 | 1,191
acute quadriplegic myopathy 23 | 1,158
astrocytoma 23 | 1,146
Pick disease 22 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Duchenne muscular dystrophy 21 | 601
Multiple myeloma 21 | 1,332
Orbital separation excessive 21 | 244
Breast Neoplasms 20 | 445
Dull intelligence 20 | 645
Epilepsy 20 | 792
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
Short stature 20 | 531
Waldenstrons macroglobulinemia 20 | 765
pediatric high grade glioma 20 | 1,064
spina bifida 20 | 1,074
Seizures 19 | 596
cutaneous lupus erythematosus 19 | 1,057
pituitary cancer 19 | 1,972
Downward slant of palpebral fissure 18 | 158
Mammary Neoplasms 18 | 425
Muscle hypotonia 18 | 571
Neoplasm Invasiveness 18 | 161
Prostatic Neoplasms 18 | 495
adrenocortical carcinoma 18 | 1,428
dermatomyositis 18 | 966
Blepharoptosis 17 | 231
Carcinoma, Hepatocellular 17 | 228
Cryptorchidism 17 | 296
Liver carcinoma 17 | 240
Melanoma 17 | 711
Renal Cell Carcinoma 17 | 214
Bipolar Disorder 16 | 666
Byzanthine arch palate 16 | 194
Cognitive delay 16 | 608
Global developmental delay 16 | 608
High forehead 16 | 102
Mental and motor retardation 16 | 608
Stomach Neoplasms 16 | 300
Tall forehead 16 | 102
primary Sjogren syndrome 16 | 735
Depressive disorder 15 | 409
Hypoplastic mandible condyle 15 | 275
Kidney disease 15 | 430
Mandibular hypoplasia 15 | 275
Micrognathism 15 | 275
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
esophageal adenocarcinoma 15 | 737
Acquired scoliosis 14 | 281
Cleft Palate 14 | 271
Curvature of spine 14 | 282
Pectus excavatum 14 | 100
Strabismus 14 | 270
gastric carcinoma 14 | 807

Tissue

Endocrine System 206 | 18,159
Digestive Tract 202 | 17,369
Skin and soft tissues 201 | 17,230
Female tissues 200 | 17,400
Liver and Pancreas 200 | 16,750
Nervous System 200 | 16,725
Urinary Tract 200 | 16,678
Male tissues 199 | 17,142
Blood and immune system 197 | 16,909
Respiratory system 192 | 16,393
Cardiovascular System 188 | 15,192

Target Family

Non-IDG 127 | 12,091
Kinase 43 | 634
Enzyme 28 | 4,145
GPCR 8 | 408
Transporter 1 | 473

KEGG Pathway

Regulation of actin cytoskelet... 207 | 207
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
Integrin alpha-9 ITGA9 Tbio Non-IDG -1.46619 29.0 124
Integrin beta-8 ITGB8 Tbio Non-IDG -1.47947 27.7 99
LIM domain kinase 2 LIMK2 Tchem Kinase -1.65006 41.3 405
Integrin beta-7 ITGB7 Tclin Non-IDG -1.63572 38.4 374