Development Level

Tbio 98 | 10,625
Tchem 83 | 1,890
Tclin 30 | 602
Tdark 14 | 7,003

Collection

Eligible Kinase Proteins 5 | 134

IMPC Term

preweaning lethality, complete... 11 | 633
decreased lean body mass 6 | 195
abnormal bone structure 4 | 131
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
increased circulating alkaline... 4 | 119
preweaning lethality, incomple... 4 | 260
abnormal embryo size 3 | 112
decreased circulating alanine ... 3 | 53
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
embryonic lethality prior to t... 3 | 187
enlarged heart 3 | 111
abnormal QRS complex 2 | 25
abnormal bone mineralization 2 | 55
abnormal cornea morphology 2 | 24
abnormal gait 2 | 51
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
cataract 2 | 26
corneal opacity 2 | 25
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased kidney weight 2 | 7
decreased lumbar vertebrae num... 2 | 62
decreased mature B cell number 2 | 25
decreased total body fat amoun... 2 | 186
impaired pupillary reflex 2 | 14
increased blood urea nitrogen ... 2 | 44
increased body weight 2 | 42
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased leukocyte cell numbe... 2 | 37
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
male infertility 2 | 62
tremors 2 | 34
abnormal body wall morphology 1 | 7
abnormal digit morphology 1 | 13
abnormal forebrain development 1 | 18
abnormal hair growth 1 | 8
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
absent vibrissae 1 | 14
cleft palate 1 | 6
decreased B cell number 1 | 30
decreased body length 1 | 108
decreased circulating sodium l... 1 | 18
decreased fasted circulating g... 1 | 49
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased spleen weight 1 | 13
embryonic lethality prior to o... 1 | 148
enlarged adrenal glands 1 | 3
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hydrometra 1 | 13
impaired righting response 1 | 19
increased T cell number 1 | 15
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
irregularly shaped pupil 1 | 7
mydriasis 1 | 9
narrow eye opening 1 | 15
oligodactyly 1 | 14
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
rough coat 1 | 1
small kidney 1 | 10
small superior vagus ganglion 1 | 20
sparse hair 1 | 6
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

ovarian cancer 117 | 8,484
Cancer 113 | 2,346
osteosarcoma 112 | 7,933
psoriasis 96 | 6,685
medulloblastoma, large-cell 95 | 6,234
glioblastoma 91 | 5,572
lung cancer 76 | 4,466
atypical teratoid / rhabdoid tumor 73 | 4,369
oligodendroglioma 62 | 2,849
invasive ductal carcinoma 61 | 2,950
malignant mesothelioma 61 | 3,162
Breast cancer 59 | 3,094
pilocytic astrocytoma 58 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 57 | 3,289
lung carcinoma 55 | 2,844
non-small cell lung cancer 54 | 2,798
Carcinoma 52 | 2,147
ependymoma 51 | 2,514
primitive neuroectodermal tumor 50 | 3,031
lung adenocarcinoma 48 | 2,713
pediatric high grade glioma 48 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,988
pancreatic cancer 46 | 2,300
ulcerative colitis 45 | 2,087
interstitial cystitis 44 | 2,299
subependymal giant cell astrocytoma 44 | 2,287
astrocytic glioma 40 | 2,241
group 4 medulloblastoma 38 | 1,875
cystic fibrosis 36 | 1,665
diabetes mellitus 36 | 1,663
group 3 medulloblastoma 35 | 2,254
pituitary cancer 35 | 1,972
adult high grade glioma 33 | 2,148
Pick disease 32 | 1,893
Mammary Neoplasms 29 | 410
astrocytoma 29 | 1,493
adrenocortical carcinoma 28 | 1,427
ductal carcinoma in situ 28 | 1,745
medulloblastoma 28 | 1,524
breast carcinoma 26 | 1,614
primary pancreatic ductal adenocarcinoma 26 | 1,271
juvenile dermatomyositis 24 | 1,189
Multiple myeloma 23 | 1,327
colon cancer 23 | 1,475
cutaneous lupus erythematosus 23 | 1,056
tuberculosis 22 | 1,557
Schizophrenia 21 | 501
spina bifida 21 | 1,064
Prostatic Neoplasms 20 | 471
posterior fossa group A ependymoma 20 | 1,511
Alzheimer's disease 19 | 644
Rheumatoid Arthritis 19 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
Renal Cell Carcinoma 18 | 199
non-small cell lung carcinoma 18 | 413
Heart disease 17 | 279
Intellectual disability 17 | 573
Parkinson's disease 17 | 364
Toxic encephalopathy 17 | 131
Vascular disease 16 | 281
acute quadriplegic myopathy 16 | 1,157
posterior fossa group B ependymoma 16 | 1,530
primary Sjogren syndrome 16 | 789
Atherosclerosis 15 | 275
Lung Neoplasms 15 | 171
Melanoma 15 | 261
Noonan Syndrome 15 | 33
Arthritis 14 | 248
Down syndrome 14 | 548
Liver carcinoma 14 | 217
Neoplasm Metastasis 14 | 138
Obesity 14 | 616
esophageal adenocarcinoma 14 | 737
Autistic Disorder 13 | 320
Cerebrovascular disease 13 | 231
Cleft palate 13 | 125
Coronary artery disease 13 | 240
Stomach Neoplasms 13 | 282
nasopharyngeal carcinoma 13 | 1,056
pancreatic carcinoma 13 | 567
Hypertension 12 | 287
Kidney disease 12 | 396
Neoplasm Invasiveness 12 | 127
Neurodegenerative disease 12 | 383
Reperfusion Injury 12 | 84
Waldenstrons macroglobulinemia 12 | 765
glioblastoma multiforme 12 | 347
non primary Sjogren syndrome sicca 12 | 840
Adenocarcinoma 11 | 115
Adenoma 11 | 165
Amyotrophic Lateral Sclerosis 11 | 431
Colorectal Neoplasms 11 | 217
Diabetes Mellitus, Non-Insulin-Dependent 11 | 157
Lung disease 11 | 132
Squamous cell carcinoma 11 | 94
aldosterone-producing adenoma 11 | 664
atypical teratoid/rhabdoid tumor 11 | 1,095
dermatomyositis 11 | 933
progressive supranuclear palsy 11 | 674

Tissue

Endocrine System 225 | 18,512
Female tissues 225 | 18,647
Nervous System 225 | 18,561
Digestive Tract 224 | 18,473
Skin and soft tissues 223 | 18,115
Urinary Tract 223 | 18,444
Liver and Pancreas 222 | 18,136
Blood and immune system 221 | 17,995
Cardiovascular System 220 | 17,958
Male tissues 219 | 17,969
Respiratory system 212 | 17,484

Target Family

Non-IDG 103 | 11,971
Kinase 56 | 634
Enzyme 55 | 4,146
Transcription Factor 7 | 1,400
Ion Channel 3 | 341
GPCR 1 | 406

KEGG Pathway

Ras signaling pathway 225 | 225
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13458 11.1 135
Phospholipase A1 member A PLA1A Tbio Enzyme -1.76413 56.8 115
Group 10 secretory phospholipase A2 PLA2G10 Tchem Enzyme -2.39398 288.4 31
Ras-related protein Ral-B RALB Tbio Enzyme -1.69182 49.7 204
Ras-related protein Ral-A RALA Tbio Enzyme -2.17133 159.2 185
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.51373 345.1 271