Development Level

Tbio 119 | 11,445
Tchem 64 | 1,598
Tclin 36 | 613
Tdark 11 | 6,588

Collection

Kinase: IDG Consortium (Target... 5 | 125

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 9 | 499
cataract 6 | 92
abnormal bone structure 5 | 187
embryonic lethality prior to t... 5 | 278
abnormal lens morphology 4 | 81
decreased body weight 4 | 161
increased circulating alkaline... 4 | 122
abnormal behavior 3 | 298
abnormal cornea morphology 3 | 31
abnormal embryo size 3 | 220
abnormal retina morphology 3 | 71
decreased circulating choleste... 3 | 93
decreased circulating triglyce... 3 | 79
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
impaired pupillary reflex 3 | 26
increased circulating choleste... 3 | 66
increased circulating sodium l... 3 | 71
increased erythrocyte cell num... 3 | 39
increased total body fat amoun... 3 | 134
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal coat appearance 2 | 31
abnormal digit morphology 2 | 10
abnormal gait 2 | 69
abnormal retinal vasculature m... 2 | 27
abnormal sleep behavior 2 | 70
decreased bone mineral content 2 | 151
decreased circulating alkaline... 2 | 46
decreased circulating creatini... 2 | 39
decreased hematocrit 2 | 46
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased spleen weight 2 | 10
decreased total body fat amoun... 2 | 207
enlarged kidney 2 | 14
hemorrhage 2 | 23
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased startle reflex 2 | 112
limb grasping 2 | 41
male infertility 2 | 123
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal hair growth 1 | 10
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cleft palate 1 | 8
corneal opacity 1 | 32
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
enlarged adrenal glands 1 | 3
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
impaired righting response 1 | 26
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased spleen weight 1 | 10
iris synechia 1 | 3
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality 1 | 28
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Carcinoma 147 | 11,493
Cancer 124 | 2,499
ovarian cancer 120 | 8,520
osteosarcoma 112 | 7,950
glioblastoma 101 | 5,792
psoriasis 100 | 6,694
medulloblastoma, large-cell 96 | 6,241
lung cancer 91 | 4,740
atypical teratoid / rhabdoid tumor 81 | 5,112
ependymoma 81 | 4,679
Breast cancer 73 | 3,578
malignant mesothelioma 69 | 3,232
group 3 medulloblastoma 67 | 4,104
adult high grade glioma 65 | 3,801
oligodendroglioma 62 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 61 | 3,291
invasive ductal carcinoma 60 | 2,951
Astrocytoma, Pilocytic 57 | 3,081
non-small cell lung cancer 55 | 2,890
lung carcinoma 51 | 2,843
Kidney cancer 50 | 2,613
primitive neuroectodermal tumor 50 | 3,035
astrocytic glioma 49 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 49 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 49 | 2,989
lung adenocarcinoma 48 | 2,716
pancreatic cancer 48 | 2,398
Schizophrenia 46 | 1,160
diabetes mellitus 44 | 1,728
interstitial cystitis 44 | 2,312
subependymal giant cell astrocytoma 42 | 2,287
group 4 medulloblastoma 38 | 1,855
ulcerative colitis 37 | 1,819
cystic fibrosis 36 | 1,696
pituitary cancer 36 | 1,972
Intellectual disability 34 | 1,016
Pick disease 33 | 1,894
Bipolar Disorder 31 | 666
Depressive disorder 31 | 409
breast carcinoma 31 | 1,638
Epilepsy 30 | 792
Breast Neoplasms 29 | 445
Mammary Neoplasms 29 | 425
ductal carcinoma in situ 29 | 1,745
adrenocortical carcinoma 28 | 1,428
tuberculosis 28 | 2,010
Autosomal recessive predisposition 27 | 1,442
Alzheimer's disease 26 | 658
Short stature 26 | 531
Dull intelligence 25 | 645
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Poor school performance 25 | 645
Seizures 25 | 596
juvenile dermatomyositis 25 | 1,187
Melanoma 24 | 711
astrocytoma 24 | 1,146
Multiple myeloma 23 | 1,332
Toxic encephalopathy 23 | 141
cutaneous lupus erythematosus 23 | 1,057
primary pancreatic ductal adenocarcinoma 23 | 1,109
Blepharoptosis 22 | 231
Orbital separation excessive 22 | 244
colon cancer 22 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
spina bifida 22 | 1,074
Cryptorchidism 21 | 296
Hypoplastic mandible condyle 21 | 275
Mandibular hypoplasia 21 | 275
Micrognathism 21 | 275
Prostatic Neoplasms 21 | 495
Renal Cell Carcinoma 21 | 214
Cognitive delay 20 | 608
Downward slant of palpebral fissure 20 | 158
Global developmental delay 20 | 608
Heart disease 20 | 306
Mental Depression 20 | 333
Mental and motor retardation 20 | 608
Stomach Neoplasms 20 | 300
Byzanthine arch palate 19 | 194
Parkinson's disease 19 | 392
Rheumatoid arthritis 19 | 1,191
Skin cancer 19 | 469
Atherosclerosis 18 | 291
Cerebrovascular disease 18 | 238
Delayed bone age 18 | 136
Lung Neoplasms 18 | 232
Muscle hypotonia 18 | 571
Obesity 18 | 678
Strabismus 18 | 270
Acquired scoliosis 17 | 281
Autistic Disorder 17 | 364
Cleft Palate 17 | 271
Curvature of spine 17 | 282
Down syndrome 17 | 499
Hypertension 17 | 396
Arthritis 16 | 290
Small head 16 | 374
acute quadriplegic myopathy 16 | 1,158

Tissue

Endocrine System 227 | 18,159
Digestive Tract 226 | 17,369
Skin and soft tissues 222 | 17,230
Blood and immune system 221 | 16,909
Female tissues 221 | 17,400
Male tissues 219 | 17,142
Nervous System 219 | 16,725
Liver and Pancreas 218 | 16,750
Urinary Tract 217 | 16,678
Respiratory system 214 | 16,393
Cardiovascular System 205 | 15,192

Target Family

Non-IDG 106 | 12,091
Kinase 58 | 634
Enzyme 55 | 4,145
Transcription Factor 7 | 1,400
Ion Channel 3 | 344
GPCR 1 | 408

KEGG Pathway

Ras signaling pathway 230 | 230
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305