Development Level

Tbio 112 | 11,445
Tchem 48 | 1,598
Tclin 44 | 613
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 17 | 979
abnormal bone structure 9 | 187
abnormal behavior 8 | 298
embryonic lethality prior to t... 8 | 278
preweaning lethality, incomple... 8 | 499
increased startle reflex 7 | 112
cataract 6 | 92
decreased total body fat amoun... 6 | 207
abnormal embryo size 4 | 220
abnormal lens morphology 4 | 81
decreased body weight 4 | 161
embryonic lethality prior to o... 4 | 239
hyperactivity 4 | 148
impaired pupillary reflex 4 | 26
increased heart weight 4 | 62
increased total body fat amoun... 4 | 134
abnormal cornea morphology 3 | 31
abnormal gait 3 | 69
abnormal retina morphology 3 | 71
decreased bone mineral content 3 | 151
decreased circulating insulin ... 3 | 76
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased lean body mass 3 | 172
abnormal bone mineralization 2 | 38
abnormal heart morphology 2 | 162
abnormal optic disc morphology 2 | 10
abnormal pericardium morpholog... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal vocalization 2 | 21
corneal opacity 2 | 32
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased spleen weight 2 | 10
enlarged kidney 2 | 14
fused cornea and lens 2 | 5
hydrometra 2 | 53
hypoactivity 2 | 132
impaired righting response 2 | 26
increased body length 2 | 32
increased body weight 2 | 25
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
limb grasping 2 | 41
pallor 2 | 34
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal heart looping 1 | 5
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vitelline vasculature... 1 | 6
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
decreased urine magnesium leve... 1 | 3
edema 1 | 59
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hemorrhage 1 | 23
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
iris synechia 1 | 3
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 152 | 11,493
ovarian cancer 121 | 8,520
Cancer 118 | 2,499
osteosarcoma 117 | 7,950
glioblastoma 110 | 5,792
medulloblastoma, large-cell 98 | 6,241
psoriasis 98 | 6,694
lung cancer 92 | 4,740
atypical teratoid / rhabdoid tumor 88 | 5,112
ependymoma 82 | 4,679
Breast cancer 80 | 3,578
adult high grade glioma 69 | 3,801
Astrocytoma, Pilocytic 67 | 3,081
malignant mesothelioma 67 | 3,232
group 3 medulloblastoma 66 | 4,104
invasive ductal carcinoma 66 | 2,951
Kidney cancer 61 | 2,613
non-small cell lung cancer 60 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 56 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,955
oligodendroglioma 55 | 2,850
interstitial cystitis 54 | 2,312
lung carcinoma 54 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,291
lung adenocarcinoma 53 | 2,716
primitive neuroectodermal tumor 53 | 3,035
pancreatic cancer 52 | 2,398
Schizophrenia 48 | 1,160
astrocytic glioma 48 | 2,597
diabetes mellitus 43 | 1,728
subependymal giant cell astrocytoma 41 | 2,287
cystic fibrosis 37 | 1,696
tuberculosis 37 | 2,010
pituitary cancer 36 | 1,972
breast carcinoma 35 | 1,638
ulcerative colitis 35 | 1,819
ductal carcinoma in situ 34 | 1,745
group 4 medulloblastoma 34 | 1,855
adrenocortical carcinoma 32 | 1,428
Bipolar Disorder 31 | 666
Breast Neoplasms 30 | 445
Depressive disorder 30 | 409
Epilepsy 30 | 792
Mammary Neoplasms 30 | 425
Autosomal recessive predisposition 28 | 1,442
Intellectual disability 28 | 1,016
Melanoma 28 | 711
Seizures 28 | 596
colon cancer 28 | 1,478
Liver Cirrhosis, Experimental 25 | 769
Rheumatoid arthritis 25 | 1,191
cutaneous lupus erythematosus 25 | 1,057
Alzheimer's disease 24 | 658
Kidney disease 24 | 430
astrocytoma 24 | 1,146
Liver cancer 23 | 604
Mental Depression 23 | 333
Pick disease 23 | 1,894
Skin cancer 23 | 469
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
Dull intelligence 22 | 645
Low intelligence 22 | 645
Mental Retardation 22 | 645
Mental deficiency 22 | 645
Obesity 22 | 678
Poor school performance 22 | 645
pediatric high grade glioma 22 | 1,064
Heart disease 21 | 306
Prostatic Neoplasms 21 | 495
Vascular disease 21 | 319
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
Short stature 20 | 531
Stomach Neoplasms 20 | 300
Cerebrovascular disease 19 | 238
Parkinson's disease 19 | 392
Renal Cell Carcinoma 19 | 214
primary pancreatic ductal adenocarcinoma 19 | 1,109
spina bifida 19 | 1,074
Blepharoptosis 18 | 231
Lung Neoplasms 18 | 232
Multiple myeloma 18 | 1,332
Orbital separation excessive 18 | 244
Adenoma 17 | 167
Cleft Palate 17 | 271
Neoplasm Invasiveness 17 | 161
Neoplasm Metastasis 17 | 168
primary Sjogren syndrome 17 | 735
Carcinoma, Hepatocellular 16 | 228
Liver carcinoma 16 | 240
Osteoporosis 16 | 363
gastric carcinoma 16 | 807
juvenile dermatomyositis 16 | 1,187
nasopharyngeal carcinoma 16 | 1,058
Arthritis 15 | 290
Byzanthine arch palate 15 | 194
Depressed nasal bridge 15 | 195
Depressed nasal root/bridge 15 | 195
Muscle hypotonia 15 | 571

Tissue

Endocrine System 204 | 18,159
Digestive Tract 201 | 17,369
Liver and Pancreas 200 | 16,750
Nervous System 200 | 16,725
Female tissues 199 | 17,400
Skin and soft tissues 199 | 17,230
Blood and immune system 197 | 16,909
Male tissues 197 | 17,142
Urinary Tract 195 | 16,678
Respiratory system 194 | 16,393
Cardiovascular System 190 | 15,192

Target Family

Non-IDG 109 | 12,091
Kinase 46 | 634
Enzyme 37 | 4,145
GPCR 13 | 408
Ion Channel 3 | 344
Transcription Factor 1 | 1,400

KEGG Pathway

Rap1 signaling pathway 209 | 209
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.08587 12.0 153
Signal-induced proliferation-associated 1-like protein 1 SIPA1L1 Tbio Non-IDG -0.56258 5.05 40
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 ARAP3 Tbio Non-IDG -0.96067 13.8 85
Proteinase-activated receptor 4 F2RL3 Tchem GPCR -1.50044 34.1 276
Talin-2 TLN2 Tbio Non-IDG -1.36153 20.0 101
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 MAGI2 Tbio Enzyme -1.54170 33.0 178
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598