Development Level

Tbio 63 | 11,651
Tdark 13 | 6,593
Tchem 2 | 1,388

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 5 | 239
abnormal embryo size 3 | 220
increased mean corpuscular hem... 3 | 96
abnormal embryo turning 2 | 31
decreased caudal vertebrae num... 2 | 53
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
embryonic lethality prior to t... 2 | 278
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal rib morphology 1 | 10
abnormal spine curvature 1 | 9
abnormal vitreous body morphol... 1 | 10
aorta dilation 1 | 3
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
female infertility 1 | 60
increased bone mineral content 1 | 108
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
thin ventricular wall 1 | 24

Disease

ovarian cancer 47 | 8,520
Carcinoma 45 | 11,493
osteosarcoma 45 | 7,950
group 3 medulloblastoma 29 | 4,104
lung cancer 22 | 4,740
psoriasis 21 | 6,694
medulloblastoma, large-cell 20 | 6,241
atypical teratoid / rhabdoid tumor 19 | 5,112
ependymoma 19 | 4,679
glioblastoma 19 | 5,792
oligodendroglioma 16 | 2,850
pancreatic cancer 15 | 2,398
malignant mesothelioma 14 | 3,232
primitive neuroectodermal tumor 14 | 3,035
acute quadriplegic myopathy 13 | 1,158
Kidney cancer 12 | 2,613
lung adenocarcinoma 12 | 2,716
Multiple myeloma 11 | 1,332
astrocytic glioma 11 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
astrocytoma 10 | 1,146
group 4 medulloblastoma 10 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Autosomal recessive predisposition 9 | 1,442
invasive ductal carcinoma 9 | 2,951
pituitary cancer 9 | 1,972
primary pancreatic ductal adenocarcinoma 9 | 1,109
Cancer 8 | 2,499
acute myeloid leukemia 8 | 783
diabetes mellitus 8 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
tuberculosis 8 | 2,010
Pick disease 7 | 1,894
Waldenstrons macroglobulinemia 7 | 765
adult high grade glioma 7 | 3,801
Breast cancer 6 | 3,578
Rheumatoid arthritis 6 | 1,191
adrenocortical carcinoma 6 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
non-small cell lung cancer 6 | 2,890
spina bifida 6 | 1,074
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Schizophrenia 5 | 1,160
colon cancer 5 | 1,478
dermatomyositis 5 | 966
pediatric high grade glioma 5 | 1,064
Carcinoma, Hepatocellular 4 | 228
Down syndrome 4 | 499
Duchenne muscular dystrophy 4 | 601
Dyskeratosis congenita 4 | 24
Failure to gain weight 4 | 365
Liver carcinoma 4 | 240
Male infertility 4 | 206
Pediatric failure to thrive 4 | 365
Pontocerebellar hypoplasia 4 | 36
atypical teratoid/rhabdoid tumor 4 | 357
medulloblastoma 4 | 720
Alzheimer's disease 3 | 658
Amyotrophic lateral sclerosis 3 | 451
Carcinoma, Renal Cell 3 | 124
Cerebral atrophy 3 | 178
Cholestasis 3 | 155
Fetal Growth Retardation 3 | 189
Glycogen storage disease 3 | 39
Infant, Small for Gestational Age 3 | 176
Intellectual disability 3 | 1,016
Intrauterine retardation 3 | 176
Liver cancer 3 | 604
Neurodegenerative disease 3 | 414
Renal Cell Carcinoma 3 | 214
Sparse hair 3 | 59
Stomach Neoplasms 3 | 300
Thin, sparse hair 3 | 59
aldosterone-producing adenoma 3 | 665
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
lung carcinoma 3 | 2,843
non-small cell lung carcinoma 3 | 317
pancreatic carcinoma 3 | 562
periodontitis 3 | 293
Anemia 2 | 365
Bladder Neoplasm 2 | 112
Contracture 2 | 96
Contracture of joint 2 | 93
Diarrhea 2 | 253
Flexion contracture 2 | 93
Flexion contractures of joints 2 | 93
Hemoglobin low 2 | 124
Hyperreflexia 2 | 209
Impaired exercise tolerance 2 | 42
Liver Cirrhosis 2 | 181
Liver Cirrhosis, Experimental 2 | 769
Urinary Bladder Neoplasms 2 | 114
hereditary spastic paraplegia 2 | 318
tuberculosis and treatment for 6 months 2 | 409

Tissue

Endocrine System 77 | 18,159
Male tissues 77 | 17,142
Blood and immune system 76 | 16,909
Digestive Tract 76 | 17,369
Female tissues 76 | 17,400
Liver and Pancreas 76 | 16,750
Nervous System 76 | 16,725
Respiratory system 76 | 16,393
Skin and soft tissues 76 | 17,230
Urinary Tract 75 | 16,678
Cardiovascular System 72 | 15,192

Target Family

Non-IDG 48 | 12,091
Enzyme 26 | 4,145
Kinase 4 | 634

KEGG Pathway

RNA degradation 78 | 78
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly(A)-specific ribonuclease PARN PARN Tbio Enzyme -1.87605 76.4 263
U6 snRNA-associated Sm-like protein LSm5 LSM5 Tdark Non-IDG -0.98876 8.80 46
ATP-dependent 6-phosphofructokinase, liver type PFKL Tbio Kinase -2.07015 107.6 240
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 PAN2 Tbio Enzyme -0.66901 4.14 87
Nuclear nucleic acid-binding protein C1D C1D Tbio Non-IDG -1.81349 69.3 176
Probable ATP-dependent RNA helicase DDX6 DDX6 Tbio Enzyme -1.81481 65.6 302
CCR4-NOT transcription complex subunit 6 CNOT6 Tbio Non-IDG -1.27015 19.4 125
ATP-dependent 6-phosphofructokinase, platelet type PFKP Tbio Kinase -1.93210 79.7 302
Poly(A)-specific ribonuclease PNLDC1 PNLDC1 Tbio Enzyme -0.61101 2.88 60
U6 snRNA-associated Sm-like protein LSm7 LSM7 Tbio Non-IDG -0.95219 6.58 100