Development Level

Tbio 101 | 11,445
Tclin 39 | 613
Tchem 23 | 1,598
Tdark 9 | 6,588

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 6 | 499
abnormal behavior 4 | 298
abnormal embryo size 4 | 220
enlarged heart 4 | 210
increased mean corpuscular vol... 4 | 92
abnormal heart morphology 3 | 162
embryonic growth retardation 3 | 106
increased bone mineral content 3 | 108
abnormal bone structure 2 | 187
abnormal retinal vasculature m... 2 | 27
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating sodium l... 2 | 22
decreased lean body mass 2 | 135
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
abnormal clavicle morphology 1 | 6
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryonic autopod pla... 1 | 2
abnormal facial morphology 1 | 17
abnormal hair growth 1 | 10
abnormal kidney morphology 1 | 65
abnormal liver morphology 1 | 17
abnormal pancreas morphology 1 | 13
abnormal placenta morphology 1 | 5
abnormal posture 1 | 2
abnormal rib morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal whole-body plethysmog... 1 | 4
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased T cell number 1 | 6
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased cellular hemoglobin ... 1 | 1
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
macrophthalmia 1 | 2
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thin ventricular wall 1 | 24
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 102 | 11,493
ovarian cancer 92 | 8,520
osteosarcoma 82 | 7,950
medulloblastoma, large-cell 78 | 6,241
lung cancer 60 | 4,740
psoriasis 54 | 6,694
atypical teratoid / rhabdoid tumor 53 | 5,112
glioblastoma 50 | 5,792
ependymoma 49 | 4,679
group 3 medulloblastoma 48 | 4,104
Breast cancer 44 | 3,578
primitive neuroectodermal tumor 38 | 3,035
Autosomal recessive predisposition 37 | 1,442
invasive ductal carcinoma 36 | 2,951
non-small cell lung cancer 34 | 2,890
astrocytic glioma 33 | 2,597
malignant mesothelioma 33 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
Astrocytoma, Pilocytic 31 | 3,081
Kidney cancer 31 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
tuberculosis 31 | 2,010
oligodendroglioma 30 | 2,850
lung adenocarcinoma 29 | 2,716
adult high grade glioma 28 | 3,801
Pick disease 25 | 1,894
interstitial cystitis 25 | 2,312
Chronic heart failure 24 | 46
group 4 medulloblastoma 24 | 1,855
ulcerative colitis 24 | 1,819
Atrial Fibrillation 23 | 124
colon cancer 23 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
pancreatic cancer 23 | 2,398
Cancer 21 | 2,499
Myocardial Perfusion Imaging Adjunct 21 | 25
Platelet Aggregation Inhibition 21 | 22
Prevention of Cerebral Thrombosis 21 | 29
breast carcinoma 21 | 1,638
diabetes mellitus 20 | 1,728
ductal carcinoma in situ 20 | 1,745
lung carcinoma 20 | 2,843
Multiple myeloma 19 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Intellectual disability 18 | 1,016
pituitary cancer 16 | 1,972
subependymal giant cell astrocytoma 16 | 2,287
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
pediatric high grade glioma 15 | 1,064
Waldenstrons macroglobulinemia 14 | 765
astrocytoma 14 | 1,146
nasopharyngeal carcinoma 14 | 1,058
Epilepsy 13 | 792
Schizophrenia 13 | 1,160
gastric carcinoma 13 | 807
non primary Sjogren syndrome sicca 13 | 891
cystic fibrosis 12 | 1,696
primary pancreatic ductal adenocarcinoma 12 | 1,109
Atopic dermatitis 11 | 952
Hypogonadism 11 | 173
Mental Depression 11 | 333
Muscle hypotonia 11 | 571
Seizures 11 | 596
adrenocortical carcinoma 11 | 1,428
dermatomyositis 11 | 966
Cognitive delay 10 | 608
Depressive disorder 10 | 409
Endometriosis 10 | 540
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Nystagmus 10 | 317
Obesity 10 | 678
Short stature 10 | 531
Colorectal Neoplasms 9 | 243
Hypertensive disease 9 | 292
Optic Atrophy 9 | 242
Purine nucleoside phosphorylase deficiency 9 | 11
Retinitis Pigmentosa 9 | 226
acute myeloid leukemia 9 | 783
acute quadriplegic myopathy 9 | 1,158
cutaneous lupus erythematosus 9 | 1,057
primary Sjogren syndrome 9 | 735
Bipolar Disorder 8 | 666
Cerebellar Ataxia 8 | 304
Dysarthria 8 | 192
Dysuria 8 | 26
Low Vision 8 | 174
Nocturia 8 | 9
Osteoporosis 8 | 363
Sensorineural Hearing Loss (disorder) 8 | 284
Urgent desire to urinate 8 | 11
Urinary Incontinence 8 | 50
Urinary Tract Irritation 8 | 24
Visual Impairment 8 | 174
pancreatic carcinoma 8 | 562
progressive supranuclear palsy 8 | 676

Tissue

Endocrine System 170 | 18,159
Digestive Tract 168 | 17,369
Blood and immune system 167 | 16,909
Skin and soft tissues 167 | 17,230
Female tissues 166 | 17,400
Male tissues 166 | 17,142
Urinary Tract 166 | 16,678
Liver and Pancreas 165 | 16,750
Respiratory system 164 | 16,393
Nervous System 163 | 16,725
Cardiovascular System 159 | 15,192

Target Family

Enzyme 139 | 4,145
Kinase 27 | 634
Non-IDG 6 | 12,091

KEGG Pathway

Purine metabolism 172 | 172
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Adenylate kinase isoenzyme 5 AK5 Tbio Kinase -1.83209 76.0 225
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.13751 1324.4 108
Ectonucleoside triphosphate diphosphohydrolase 2 ENTPD2 Tchem Enzyme -2.37613 245.8 150
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A Tchem Enzyme -1.53120 38.8 218
Retinal guanylyl cyclase 1 GUCY2D Tbio Kinase -2.20658 167.7 205
GTP:AMP phosphotransferase AK3, mitochondrial AK3 Tbio Kinase -1.37969 23.5 249
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.93014 835.0 246