Development Level

Tbio 109 | 11,445
Tchem 64 | 1,598
Tclin 24 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 15 | 979
preweaning lethality, incomple... 11 | 499
embryonic lethality prior to t... 9 | 278
decreased vertical activity 6 | 208
abnormal heart morphology 5 | 162
decreased body weight 5 | 161
enlarged heart 5 | 210
short tibia 5 | 97
decreased bone mineral content 4 | 151
embryonic lethality prior to o... 4 | 239
increased total body fat amoun... 4 | 134
abnormal bone mineralization 3 | 38
abnormal retina morphology 3 | 71
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased hematocrit 3 | 46
decreased lymphocyte cell numb... 3 | 83
embryonic growth retardation 3 | 106
increased circulating triglyce... 3 | 42
increased lean body mass 3 | 172
increased neutrophil cell numb... 3 | 46
small superior vagus ganglion 3 | 74
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal lung morphology 2 | 26
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased lean body mass 2 | 135
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
edema 2 | 59
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
limb grasping 2 | 41
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
abnormal brain morphology 1 | 13
abnormal cecum morphology 1 | 7
abnormal coat appearance 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased threshold for audito... 1 | 26
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
enlarged uterus 1 | 11
female infertility 1 | 60
hydroencephaly 1 | 14
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased eosinophil cell numb... 1 | 11
increased heart rate variabili... 1 | 7
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 156 | 11,493
Cancer 137 | 2,499
ovarian cancer 132 | 8,520
glioblastoma 110 | 5,792
osteosarcoma 107 | 7,950
psoriasis 106 | 6,694
lung cancer 89 | 4,740
atypical teratoid / rhabdoid tumor 87 | 5,112
Breast cancer 83 | 3,578
ependymoma 82 | 4,679
medulloblastoma, large-cell 82 | 6,241
Astrocytoma, Pilocytic 66 | 3,081
Kidney cancer 62 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,291
malignant mesothelioma 61 | 3,232
invasive ductal carcinoma 59 | 2,951
pancreatic cancer 58 | 2,398
adult high grade glioma 57 | 3,801
group 3 medulloblastoma 54 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,955
subependymal giant cell astrocytoma 50 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 49 | 2,989
primitive neuroectodermal tumor 48 | 3,035
ulcerative colitis 48 | 1,819
lung carcinoma 47 | 2,843
Schizophrenia 46 | 1,160
diabetes mellitus 45 | 1,728
interstitial cystitis 45 | 2,312
cystic fibrosis 44 | 1,696
non-small cell lung cancer 44 | 2,890
lung adenocarcinoma 42 | 2,716
tuberculosis 42 | 2,010
oligodendroglioma 41 | 2,850
astrocytic glioma 40 | 2,597
breast carcinoma 40 | 1,638
ductal carcinoma in situ 39 | 1,745
Breast Neoplasms 36 | 445
colon cancer 36 | 1,478
Autosomal recessive predisposition 35 | 1,442
Mammary Neoplasms 35 | 425
Prostatic Neoplasms 35 | 495
adrenocortical carcinoma 35 | 1,428
pituitary cancer 35 | 1,972
Heart disease 32 | 306
Short stature 32 | 531
primary pancreatic ductal adenocarcinoma 32 | 1,109
Intellectual disability 31 | 1,016
Neoplasm Metastasis 31 | 168
Rheumatoid arthritis 31 | 1,191
Vascular disease 31 | 319
Stomach Neoplasms 30 | 300
Kidney disease 29 | 430
Lung Neoplasms 29 | 232
Neoplasm Invasiveness 29 | 161
juvenile dermatomyositis 28 | 1,187
Carcinoma, Hepatocellular 27 | 228
Liver carcinoma 27 | 240
Orbital separation excessive 27 | 244
Arthritis 26 | 290
Dull intelligence 26 | 645
Liver Cirrhosis, Experimental 26 | 769
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
Hypoplastic mandible condyle 25 | 275
Mandibular hypoplasia 25 | 275
Micrognathism 25 | 275
Pick disease 25 | 1,894
pediatric high grade glioma 25 | 1,064
Hypertension 24 | 396
Obesity 24 | 678
dermatomyositis 24 | 966
Acquired scoliosis 23 | 281
Carcinoma, Squamous Cell 23 | 110
Cryptorchidism 23 | 296
Curvature of spine 23 | 282
acute quadriplegic myopathy 23 | 1,158
cutaneous lupus erythematosus 23 | 1,057
group 4 medulloblastoma 23 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Mental and motor retardation 22 | 608
Squamous cell carcinoma 22 | 129
autosomal dominant Emery-Dreifuss muscular dystrophy 22 | 510
nasopharyngeal carcinoma 22 | 1,058
spina bifida 22 | 1,074
Adenoma 21 | 167
Bipolar Disorder 21 | 666
Melanoma 21 | 711
Multiple myeloma 21 | 1,332
gastric carcinoma 21 | 807
Duchenne muscular dystrophy 20 | 601
Endometriosis 20 | 540
Frontal bossing 20 | 157
Osteoporosis 20 | 363
astrocytoma 20 | 1,146
Cleft Palate 19 | 271
Muscle hypotonia 19 | 571

Tissue

Endocrine System 196 | 18,159
Female tissues 196 | 17,400
Digestive Tract 195 | 17,369
Male tissues 195 | 17,142
Skin and soft tissues 194 | 17,230
Nervous System 193 | 16,725
Blood and immune system 192 | 16,909
Urinary Tract 192 | 16,678
Liver and Pancreas 191 | 16,750
Respiratory system 188 | 16,393
Cardiovascular System 178 | 15,192

Target Family

Non-IDG 86 | 12,091
Kinase 45 | 634
Enzyme 39 | 4,145
Transcription Factor 12 | 1,400
GPCR 11 | 408
Ion Channel 3 | 344
Nuclear Receptor 1 | 48
Transporter 1 | 473

KEGG Pathway

Proteoglycans in cancer 198 | 198
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Collagen alpha-1(XXI) chain COL21A1 Tbio Non-IDG -0.67130 4.90 89
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Ankyrin-2 ANK2 Tbio Non-IDG -2.08421 120.5 236
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308