Development Level

Tbio 125 | 11,651
Tchem 28 | 1,388
Tdark 10 | 6,593
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 7 | 499
decreased circulating HDL chol... 4 | 68
decreased circulating choleste... 4 | 93
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
decreased bone mineral density 3 | 126
decreased total body fat amoun... 3 | 207
increased grip strength 3 | 41
male infertility 3 | 123
vertebral fusion 3 | 23
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating free fat... 2 | 31
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
increased circulating aspartat... 2 | 15
increased circulating free fat... 2 | 20
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal esophagus morphology 1 | 5
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal liver morphology 1 | 17
abnormal pancreas morphology 1 | 13
abnormal pelvic girdle bone mo... 1 | 12
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal testis morphology 1 | 43
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent adrenal gland 1 | 2
absent lymph nodes 1 | 3
absent startle reflex 1 | 24
anophthalmia 1 | 33
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased anxiety-related resp... 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glycerol... 1 | 9
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
pallor 1 | 34
prolonged QT interval 1 | 38
shortened ST segment 1 | 10
small adrenal glands 1 | 16
small liver 1 | 8
small seminal vesicle 1 | 10
small spleen 1 | 19
small testis 1 | 58

Disease

ovarian cancer 121 | 8,520
Carcinoma 104 | 11,493
osteosarcoma 96 | 7,950
glioblastoma 73 | 5,792
psoriasis 68 | 6,694
medulloblastoma, large-cell 65 | 6,241
atypical teratoid / rhabdoid tumor 62 | 5,112
lung cancer 51 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,962
Breast cancer 45 | 3,578
Multiple myeloma 41 | 1,332
lung adenocarcinoma 40 | 2,716
ependymoma 39 | 4,679
Cancer 36 | 2,499
adult high grade glioma 36 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
diabetes mellitus 33 | 1,728
group 3 medulloblastoma 33 | 4,104
invasive ductal carcinoma 33 | 2,951
Astrocytoma, Pilocytic 30 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
pancreatic cancer 29 | 2,398
non-small cell lung cancer 28 | 2,890
Kidney cancer 26 | 2,613
astrocytoma 26 | 1,146
oligodendroglioma 26 | 2,850
primitive neuroectodermal tumor 26 | 3,035
subependymal giant cell astrocytoma 24 | 2,287
acute quadriplegic myopathy 23 | 1,158
Prostatic Neoplasms 22 | 495
group 4 medulloblastoma 22 | 1,855
juvenile dermatomyositis 22 | 1,187
Rheumatoid arthritis 21 | 1,191
active Crohn's disease 20 | 922
astrocytic glioma 20 | 2,597
Pick disease 19 | 1,894
malignant mesothelioma 19 | 3,232
pituitary cancer 19 | 1,972
Autosomal recessive predisposition 18 | 1,442
pediatric high grade glioma 18 | 1,064
Neurodegenerative disease 16 | 414
non primary Sjogren syndrome sicca 16 | 891
tuberculosis 16 | 2,010
Schizophrenia 15 | 1,160
Vascular disease 15 | 319
cystic fibrosis 15 | 1,696
dermatomyositis 15 | 966
ulcerative colitis 15 | 1,819
Alzheimer's disease 14 | 658
Waldenstrons macroglobulinemia 14 | 765
interstitial cystitis 14 | 2,312
lung carcinoma 13 | 2,843
Duchenne muscular dystrophy 12 | 601
Intellectual disability 12 | 1,016
Parkinson's disease 12 | 392
ductal carcinoma in situ 12 | 1,745
Bipolar Disorder 11 | 666
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
esophageal adenocarcinoma 11 | 737
medulloblastoma 11 | 720
pancreatic carcinoma 11 | 562
spina bifida 11 | 1,074
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
breast carcinoma 10 | 1,638
colon cancer 10 | 1,478
Muscle hypotonia 9 | 571
Amyotrophic lateral sclerosis 8 | 451
Depressive disorder 8 | 409
Down syndrome 8 | 499
Epilepsy 8 | 792
Nerve Degeneration 8 | 121
Short stature 8 | 531
acute myeloid leukemia 8 | 783
aldosterone-producing adenoma 8 | 665
cutaneous lupus erythematosus 8 | 1,057
primary pancreatic ductal adenocarcinoma 8 | 1,109
progressive supranuclear palsy 8 | 676
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
Toxic encephalopathy 7 | 141
adrenocortical carcinoma 7 | 1,428
hepatocellular carcinoma 7 | 547
hereditary spastic paraplegia 7 | 318
posterior fossa group A ependymoma 7 | 468
tuberculosis and treatment for 6 months 7 | 409
Asthma 6 | 385
Carcinoma, Hepatocellular 6 | 228
Failure to gain weight 6 | 365
Liver carcinoma 6 | 240
Multiple Sclerosis 6 | 540
Pediatric failure to thrive 6 | 365
Seizures 6 | 596

Tissue

Endocrine System 162 | 18,159
Female tissues 161 | 17,400
Male tissues 161 | 17,142
Digestive Tract 160 | 17,369
Urinary Tract 160 | 16,678
Blood and immune system 159 | 16,909
Cardiovascular System 158 | 15,192
Skin and soft tissues 158 | 17,230
Liver and Pancreas 157 | 16,750
Nervous System 157 | 16,725
Respiratory system 157 | 16,393

Target Family

Non-IDG 105 | 12,091
Enzyme 41 | 4,145
Kinase 10 | 634
Transcription Factor 8 | 1,400

KEGG Pathway

Protein processing in endoplas... 164 | 164
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Inactive caspase-12 CASP12 Tbio Enzyme -2.64252 415.1 429
Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Tbio Non-IDG -2.81111 643.5 577
DnaJ homolog subfamily C member 5B DNAJC5B Tdark Non-IDG -0.62006 4.33 67
Mannosyl-oligosaccharide glucosidase MOGS Tbio Enzyme -2.28289 185.6 149
E3 ubiquitin-protein ligase RNF5 RNF5 Tbio Enzyme -1.20054 15.1 166
Cyclic AMP-dependent transcription factor ATF-6 beta ATF6B Tbio Transcription Factor -1.03459 8.22 6
Calpain-2 catalytic subunit CAPN2 Tchem Non-IDG -1.69585 48.5 220
Hypoxia up-regulated protein 1 HYOU1 Tbio Non-IDG -1.99998 112.6 246
Calreticulin CALR Tbio Non-IDG -3.19563 1544.2 778