Development Level

Tbio 118 | 10,625
Tchem 33 | 1,890
Tdark 13 | 7,003
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 9 | 633
increased or absent threshold ... 5 | 128
preweaning lethality, incomple... 5 | 260
increased grip strength 4 | 83
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
decreased total body fat amoun... 3 | 186
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
male infertility 3 | 62
short tibia 3 | 82
vertebral fusion 3 | 23
abnormal embryo size 2 | 112
cardiovascular system phenotyp... 2 | 35
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased circulating free fat... 2 | 39
decreased lean body mass 2 | 195
increased circulating HDL chol... 2 | 63
increased circulating free fat... 2 | 17
increased erythrocyte cell num... 2 | 26
increased mean corpuscular vol... 2 | 91
shortened QT interval 2 | 4
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal esophagus morphology 1 | 4
abnormal forebrain development 1 | 18
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal neural tube closure 1 | 37
abnormal pancreas morphology 1 | 6
abnormal pelvic girdle bone mo... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal skin coloration 1 | 18
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
abnormal vitreous body morphol... 1 | 7
absent adrenal gland 1 | 1
absent lymph nodes 1 | 3
anophthalmia 1 | 20
decreased IgG1 level 1 | 4
decreased Ly6C-positive mature... 1 | 4
decreased T cell number 1 | 31
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased effector memory CD8-... 1 | 24
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
enlarged thymus 1 | 4
hypoactivity 1 | 89
increased CD11b-high dendritic... 1 | 5
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating glycerol... 1 | 11
increased circulating sodium l... 1 | 71
increased dendritic cell numbe... 1 | 2
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased prepulse inhibition 1 | 21
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
pallor 1 | 13
small adrenal glands 1 | 15
small liver 1 | 8
small seminal vesicle 1 | 6
small spleen 1 | 11
small testis 1 | 37
vertebral transformation 1 | 12

Disease

ovarian cancer 120 | 8,484
osteosarcoma 96 | 7,933
glioblastoma 70 | 5,572
psoriasis 68 | 6,685
medulloblastoma, large-cell 65 | 6,234
atypical teratoid / rhabdoid tumor 51 | 4,369
lung cancer 49 | 4,466
Breast cancer 44 | 3,094
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,795
Multiple myeloma 41 | 1,327
lung adenocarcinoma 40 | 2,713
pediatric high grade glioma 37 | 2,712
Cancer 36 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
diabetes mellitus 33 | 1,663
invasive ductal carcinoma 33 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,988
pilocytic astrocytoma 30 | 3,086
astrocytoma 28 | 1,493
ependymoma 28 | 2,514
non-small cell lung cancer 28 | 2,798
pancreatic cancer 28 | 2,300
oligodendroglioma 26 | 2,849
primitive neuroectodermal tumor 26 | 3,031
subependymal giant cell astrocytoma 24 | 2,287
acute quadriplegic myopathy 23 | 1,157
Prostatic Neoplasms 22 | 471
juvenile dermatomyositis 22 | 1,189
Rheumatoid Arthritis 21 | 1,160
active Crohn's disease 20 | 918
group 3 medulloblastoma 20 | 2,254
medulloblastoma 20 | 1,524
Pick disease 19 | 1,893
group 4 medulloblastoma 19 | 1,875
malignant mesothelioma 19 | 3,162
pituitary cancer 19 | 1,972
astrocytic glioma 18 | 2,241
ulcerative colitis 18 | 2,087
adult high grade glioma 17 | 2,148
non primary Sjogren syndrome sicca 16 | 840
cystic fibrosis 15 | 1,665
dermatomyositis 15 | 933
Neurodegenerative disease 14 | 383
Vascular disease 14 | 281
Waldenstrons macroglobulinemia 14 | 765
interstitial cystitis 14 | 2,299
lung carcinoma 13 | 2,844
Alzheimer's disease 12 | 644
Duchenne muscular dystrophy 12 | 602
atypical teratoid/rhabdoid tumor 12 | 1,095
ductal carcinoma in situ 12 | 1,745
posterior fossa group A ependymoma 12 | 1,511
primary pancreatic ductal adenocarcinoma 12 | 1,271
Parkinson's disease 11 | 364
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
esophageal adenocarcinoma 11 | 737
pancreatic carcinoma 11 | 567
spina bifida 11 | 1,064
tuberculosis and treatment for 6 months 11 | 686
IGA Glomerulonephritis 10 | 454
colon cancer 10 | 1,475
sonic hedgehog group medulloblastoma 10 | 1,482
Carcinoma 9 | 2,147
tuberculosis 9 | 1,557
Down syndrome 8 | 548
Toxic encephalopathy 8 | 131
acute myeloid leukemia 8 | 780
aldosterone-producing adenoma 8 | 664
breast carcinoma 8 | 1,614
cutaneous lupus erythematosus 8 | 1,056
posterior fossa group B ependymoma 8 | 1,530
progressive supranuclear palsy 8 | 674
Amyotrophic Lateral Sclerosis 7 | 431
Mammary Neoplasms 7 | 410
adrenocortical carcinoma 7 | 1,427
hepatocellular carcinoma 7 | 532
tuberculosis and treatment for 3 months 7 | 327
Asthma 6 | 349
Colonic Neoplasms 6 | 126
Congenital disorder of glycosylation 6 | 53
Liver carcinoma 6 | 217
Machado-Joseph disease 6 | 18
Multiple Sclerosis 6 | 498
Nerve Degeneration 6 | 73
hereditary spastic paraplegia 6 | 313
Atopic dermatitis 5 | 944
Myocardial Ischemia 5 | 169
SPINOCEREBELLAR ATAXIA 17 5 | 9
Stevens-Johnson syndrome 5 | 78
gastric cancer 5 | 430
gastric carcinoma 5 | 832
glioblastoma multiforme 5 | 347
non-small cell lung carcinoma 5 | 413
Male infertility 4 | 170
Polycystic Ovary Syndrome 4 | 332
Schizophrenia 4 | 501
fibroadenoma 4 | 557
nasopharyngeal carcinoma 4 | 1,056
periodontitis 4 | 269

Tissue

Blood and immune system 165 | 17,995
Digestive Tract 165 | 18,473
Endocrine System 165 | 18,512
Female tissues 165 | 18,647
Male tissues 165 | 17,969
Nervous System 165 | 18,561
Skin and soft tissues 165 | 18,115
Urinary Tract 165 | 18,444
Cardiovascular System 164 | 17,958
Liver and Pancreas 164 | 18,136
Respiratory system 163 | 17,484

Target Family

Non-IDG 106 | 11,971
Enzyme 41 | 4,146
Kinase 10 | 634
Transcription Factor 8 | 1,400

KEGG Pathway

Protein processing in endoplas... 165 | 165
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Vesicular integral-membrane protein VIP36 LMAN2 Tbio Non-IDG -1.35463 24.9 101
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
ER degradation-enhancing alpha-mannosidase-like protein 3 EDEM3 Tbio Enzyme -0.45279 2.45 72
Protein sel-1 homolog 2 SEL1L2 Tdark Non-IDG 0.00000 12
Cytoskeleton-associated protein 4 CKAP4 Tbio Non-IDG -1.40375 25.5 174
Nucleotide exchange factor SIL1 SIL1 Tbio Non-IDG -2.97229 967.7 187
Protein transport protein Sec61 subunit alpha isoform 1 SEC61A1 Tbio Non-IDG -2.43916 280.2 94
78 kDa glucose-regulated protein HSPA5 Tchem Non-IDG -3.28487 2003.3 918
Protein disulfide-isomerase A4 PDIA4 Tbio Enzyme -1.63645 41.6 248