Development Level

Tchem 44 | 1,598
Tbio 34 | 11,445
Tclin 19 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
enlarged heart 4 | 210
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
decreased body weight 3 | 161
increased circulating alkaline... 3 | 122
abnormal bone mineralization 2 | 38
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased leukocyte cell numbe... 2 | 73
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased circulating LDL chol... 2 | 13
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
small testis 2 | 58
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal response to tactile s... 1 | 17
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
syndactyly 1 | 23
thick ventricular wall 1 | 7
thrombocytosis 1 | 27

Disease

Cancer 79 | 2,499
Carcinoma 78 | 11,493
ovarian cancer 69 | 8,520
osteosarcoma 58 | 7,950
Breast cancer 56 | 3,578
glioblastoma 55 | 5,792
psoriasis 55 | 6,694
lung cancer 54 | 4,740
medulloblastoma, large-cell 44 | 6,241
atypical teratoid / rhabdoid tumor 42 | 5,112
Breast Neoplasms 36 | 445
Prostatic Neoplasms 36 | 495
ependymoma 36 | 4,679
Mammary Neoplasms 35 | 425
Schizophrenia 32 | 1,160
malignant mesothelioma 32 | 3,232
Kidney cancer 31 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
oligodendroglioma 30 | 2,850
invasive ductal carcinoma 28 | 2,951
pancreatic cancer 28 | 2,398
breast carcinoma 27 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
ductal carcinoma in situ 26 | 1,745
group 3 medulloblastoma 25 | 4,104
lung adenocarcinoma 25 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
non-small cell lung cancer 24 | 2,890
primitive neuroectodermal tumor 24 | 3,035
Lung Neoplasms 23 | 232
subependymal giant cell astrocytoma 23 | 2,287
Carcinoma, Hepatocellular 22 | 228
Epilepsy 22 | 792
Liver carcinoma 22 | 240
adult high grade glioma 22 | 3,801
diabetes mellitus 22 | 1,728
interstitial cystitis 22 | 2,312
Astrocytoma, Pilocytic 21 | 3,081
Intellectual disability 21 | 1,016
astrocytic glioma 21 | 2,597
Dull intelligence 20 | 645
Hypoplastic mandible condyle 20 | 275
Low intelligence 20 | 645
Mandibular hypoplasia 20 | 275
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Micrognathism 20 | 275
Poor school performance 20 | 645
Seizures 20 | 596
Short stature 20 | 531
Stomach Neoplasms 20 | 300
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Blepharoptosis 19 | 231
Obesity 19 | 678
adrenocortical carcinoma 19 | 1,428
cystic fibrosis 19 | 1,696
juvenile dermatomyositis 19 | 1,187
tuberculosis 19 | 2,010
ulcerative colitis 19 | 1,819
Autosomal recessive predisposition 18 | 1,442
Bipolar Disorder 18 | 666
group 4 medulloblastoma 18 | 1,855
Adenoma 17 | 167
Downward slant of palpebral fissure 17 | 158
Orbital separation excessive 17 | 244
Renal Cell Carcinoma 17 | 214
colon cancer 17 | 1,478
Byzanthine arch palate 16 | 194
Cognitive delay 16 | 608
Frontal bossing 16 | 157
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
Multiple myeloma 16 | 1,332
Muscle hypotonia 16 | 571
Neoplasm Metastasis 16 | 168
Rheumatoid arthritis 16 | 1,191
Strabismus 16 | 270
lung carcinoma 16 | 2,843
Cryptorchidism 15 | 296
Pick disease 15 | 1,894
Vascular disease 15 | 319
astrocytoma 15 | 1,146
Acquired scoliosis 14 | 281
Adenocarcinoma 14 | 122
Colonic Neoplasms 14 | 142
Concave bridge of nose 14 | 195
Curvature of spine 14 | 282
Delayed bone age 14 | 136
Depressed nasal bridge 14 | 195
Depressed nasal root/bridge 14 | 195
Depressive disorder 14 | 409
Endometrial cancer 14 | 311
Endometriosis 14 | 540
Melanoma 14 | 711
Neoplasm Invasiveness 14 | 161
Pectus excavatum 14 | 100
Squamous cell carcinoma 14 | 129
nasopharyngeal carcinoma 14 | 1,058
pituitary cancer 14 | 1,972
Hypertensive disease 13 | 292

Tissue

Endocrine System 96 | 18,159
Female tissues 96 | 17,400
Urinary Tract 96 | 16,678
Blood and immune system 95 | 16,909
Digestive Tract 95 | 17,369
Liver and Pancreas 95 | 16,750
Nervous System 95 | 16,725
Skin and soft tissues 95 | 17,230
Male tissues 94 | 17,142
Respiratory system 94 | 16,393
Cardiovascular System 89 | 15,192

Target Family

Kinase 29 | 634
Non-IDG 24 | 12,091
Transcription Factor 23 | 1,400
Enzyme 18 | 4,145
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

KEGG Pathway

Prostate cancer 97 | 97
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.13442 140.5 524
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Cyclic AMP-responsive element-binding protein 3-like protein 2 CREB3L2 Tbio Transcription Factor -2.52262 324.1 178
Endoplasmin HSP90B1 Tchem Non-IDG -2.76074 629.2 850
Insulin receptor-related protein INSRR Tchem Kinase -2.00991 100.4 287
Transcriptional regulator ERG ERG Tchem Transcription Factor -1.19111 12.3 398