Development Level

Tbio 23 | 11,445
Tchem 6 | 1,598
Tdark 2 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased total body fat amoun... 2 | 207
abnormal body wall morphology 1 | 9
abnormal embryo size 1 | 220
absent pinna reflex 1 | 23
anophthalmia 1 | 33
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased lactate dehydrogenas... 1 | 16
embryonic lethality prior to t... 1 | 278
increased body length 1 | 32
increased lean body mass 1 | 172
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 26 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
ovarian cancer 20 | 8,520
Autosomal recessive predisposition 19 | 1,442
Muscle hypotonia 16 | 571
lung cancer 15 | 4,740
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Epilepsy 13 | 792
Seizures 13 | 596
osteosarcoma 11 | 7,950
ulcerative colitis 11 | 1,819
Acidosis, Lactic 10 | 97
Hypoglycemia 10 | 152
Lactic acidemia 10 | 95
interstitial cystitis 10 | 2,312
medulloblastoma, large-cell 10 | 6,241
psoriasis 10 | 6,694
Lethargy 9 | 77
Multiple myeloma 9 | 1,332
Vomiting 9 | 116
atypical teratoid / rhabdoid tumor 9 | 5,112
glioblastoma 9 | 5,792
invasive ductal carcinoma 9 | 2,951
Metabolic acidosis 8 | 90
Methylmalonic acidemia 8 | 37
Obesity 8 | 678
ductal carcinoma in situ 8 | 1,745
group 3 medulloblastoma 8 | 4,104
malignant mesothelioma 8 | 3,232
Breast cancer 7 | 3,578
Comatose 7 | 56
Dull intelligence 7 | 645
Dystonia 7 | 164
Dystonic disease 7 | 106
Intellectual disability 7 | 1,016
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
colon cancer 7 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
Cerebellar Ataxia 6 | 304
Failure to gain weight 6 | 365
Feeding difficulties in infancy 6 | 175
Kidney cancer 6 | 2,613
Pancreatitis 6 | 123
Pediatric failure to thrive 6 | 365
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung adenocarcinoma 6 | 2,716
lung carcinoma 6 | 2,843
Cardiomyopathies 5 | 110
Feeding difficulties 5 | 127
Hepatomegaly 5 | 285
Leigh disease 5 | 100
Maple syrup urine disease 5 | 24
Short stature 5 | 531
Waldenstrons macroglobulinemia 5 | 765
adrenocortical carcinoma 5 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pancreatic cancer 5 | 2,398
Brain Edema 4 | 50
Cancer 4 | 2,499
Cerebral Edema 4 | 30
Cerebral atrophy 4 | 178
Degenerative brain disorder 4 | 100
Dehydration 4 | 40
Hyperammonemia 4 | 30
Ketonemia 4 | 11
Ketosis 4 | 11
Lactic acidosis 4 | 51
Pick disease 4 | 1,894
Propionic acidemia 4 | 16
Supratentorial atrophy 4 | 94
adult high grade glioma 4 | 3,801
breast carcinoma 4 | 1,638
nephrosclerosis 4 | 333
primitive neuroectodermal tumor 4 | 3,035
tuberculosis 4 | 2,010
Decreased platelet count 3 | 111
Growth delay 3 | 114
Growth failure 3 | 114
Growth retardation 3 | 115
Increased serum lactate 3 | 60
Infantile onset 3 | 238
Liver Cirrhosis, Experimental 3 | 769
Muscle Hypertonia 3 | 88
Myocardial Infarction 3 | 151
Poor growth 3 | 114
Thrombocytopenia 3 | 197
Very poor growth 3 | 114
aldosterone-producing adenoma 3 | 665
astrocytic glioma 3 | 2,597
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
fibroadenoma 3 | 559
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Cardiovascular System 30 | 15,192

Target Family

Enzyme 30 | 4,145
Non-IDG 2 | 12,091

KEGG Pathway

Propanoate metabolism 32 | 32
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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