Development Level

Tbio 40 | 11,445
Tchem 39 | 1,598
Tdark 9 | 6,588
Tclin 8 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
abnormal embryo size 3 | 220
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
embryonic growth retardation 2 | 106
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal embryo turning 1 | 31
abnormal glucose homeostasis 1 | 4
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal placenta size 1 | 20
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
brachydactyly 1 | 19
cataract 1 | 92
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
male infertility 1 | 123
sclerocornea 1 | 2
small testis 1 | 58
syndactyly 1 | 23
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

Carcinoma 70 | 11,493
ovarian cancer 53 | 8,520
medulloblastoma, large-cell 49 | 6,241
glioblastoma 47 | 5,792
osteosarcoma 45 | 7,950
atypical teratoid / rhabdoid tumor 42 | 5,112
Cancer 41 | 2,499
psoriasis 40 | 6,694
Breast cancer 36 | 3,578
lung cancer 34 | 4,740
group 3 medulloblastoma 33 | 4,104
adult high grade glioma 30 | 3,801
ependymoma 29 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
invasive ductal carcinoma 26 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
primitive neuroectodermal tumor 25 | 3,035
Kidney cancer 23 | 2,613
malignant mesothelioma 23 | 3,232
non-small cell lung cancer 22 | 2,890
interstitial cystitis 21 | 2,312
astrocytic glioma 20 | 2,597
breast carcinoma 20 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
oligodendroglioma 20 | 2,850
lung adenocarcinoma 19 | 2,716
pancreatic cancer 19 | 2,398
Astrocytoma, Pilocytic 18 | 3,081
adrenocortical carcinoma 18 | 1,428
ductal carcinoma in situ 17 | 1,745
colon cancer 16 | 1,478
ulcerative colitis 15 | 1,819
Intellectual disability 14 | 1,016
juvenile dermatomyositis 14 | 1,187
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Pick disease 13 | 1,894
Poor school performance 13 | 645
Schizophrenia 13 | 1,160
diabetes mellitus 13 | 1,728
lung carcinoma 13 | 2,843
subependymal giant cell astrocytoma 13 | 2,287
Breast Neoplasms 12 | 445
Cognitive delay 12 | 608
Endometriosis 12 | 540
Epilepsy 12 | 792
Global developmental delay 12 | 608
Mammary Neoplasms 12 | 425
Mental and motor retardation 12 | 608
Short stature 12 | 531
Autosomal recessive predisposition 11 | 1,442
Obesity 11 | 678
Prostatic Neoplasms 11 | 495
nasopharyngeal carcinoma 11 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Atopic dermatitis 10 | 952
Bipolar Disorder 10 | 666
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Depressive disorder 10 | 409
Seizures 10 | 596
Waldenstrons macroglobulinemia 10 | 765
group 4 medulloblastoma 10 | 1,855
Acquired scoliosis 9 | 281
Big calvaria 9 | 147
Curvature of spine 9 | 282
Hypoplastic mandible condyle 9 | 275
Increased head circumference 9 | 147
Increased size of cranium 9 | 147
Increased size of skull 9 | 147
Mandibular hypoplasia 9 | 275
Micrognathism 9 | 275
Orbital separation excessive 9 | 244
Vascular disease 9 | 319
pituitary cancer 9 | 1,972
tuberculosis 9 | 2,010
Alzheimer's disease 8 | 658
Arthritis 8 | 290
Blepharoptosis 8 | 231
Frontal bossing 8 | 157
Lung Neoplasms 8 | 232
Melanoma 8 | 711
Mental Depression 8 | 333
Multiple myeloma 8 | 1,332
Muscle hypotonia 8 | 571
Neoplasm Metastasis 8 | 168
Pectus excavatum 8 | 100
active Crohn's disease 8 | 922
medulloblastoma 8 | 720
Byzanthine arch palate 7 | 194
Intrauterine retardation 7 | 176
acute myeloid leukemia 7 | 783
cystic fibrosis 7 | 1,696
dermatomyositis 7 | 966
pediatric high grade glioma 7 | 1,064
primary Sjogren syndrome 7 | 735
spina bifida 7 | 1,074

Tissue

Endocrine System 94 | 18,159
Blood and immune system 92 | 16,909
Digestive Tract 92 | 17,369
Male tissues 92 | 17,142
Female tissues 91 | 17,400
Liver and Pancreas 91 | 16,750
Skin and soft tissues 91 | 17,230
Nervous System 90 | 16,725
Respiratory system 90 | 16,393
Urinary Tract 90 | 16,678
Cardiovascular System 86 | 15,192

Target Family

Kinase 36 | 634
Non-IDG 34 | 12,091
Enzyme 25 | 4,145
Nuclear Receptor 1 | 48

KEGG Pathway

Progesterone-mediated oocyte m... 96 | 96
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
Speedy protein E2 SPDYE2 Tdark Non-IDG 0.00000 3
Speedy protein A SPDYA Tbio Non-IDG -1.58097 42.8 145
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase PKMYT1 Tchem Kinase -1.27237 19.2 364
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574