Development Level

Tbio 15 | 11,651
Tchem 2 | 1,388

IMPC Phenotype

abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating unsatura... 1 | 1
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 15 | 11,493
Cholestasis 9 | 155
psoriasis 8 | 6,694
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Autosomal recessive predisposition 6 | 1,442
Astrocytoma, Pilocytic 5 | 3,081
Failure to gain weight 5 | 365
Pediatric failure to thrive 5 | 365
alpha-methylacyl-CoA racemase deficiency 5 | 9
ependymoma 5 | 4,679
lung cancer 5 | 4,740
malignant mesothelioma 5 | 3,232
ovarian cancer 5 | 8,520
Atopic dermatitis 4 | 952
Elevated hepatic transaminases 4 | 81
Hepatic enzyme increased 4 | 81
Hepatomegaly 4 | 285
Intrahepatic cholestasis 4 | 20
Liver Dysfunction 4 | 99
Liver enzymes abnormal 4 | 81
Liver function test increased 4 | 81
Liver function tests abnormal finding 4 | 81
Subclinical abnormal liver function tests 4 | 81
Transaminases increased 4 | 81
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
osteosarcoma 4 | 7,950
BILIARY TRACT ABNORMALITY 3 | 16
Biliary Tract Diseases 3 | 16
Blood Coagulation Disorders 3 | 42
Cerebrotendinous xanthomatosis 3 | 13
Diarrhea 3 | 253
Liver Cirrhosis 3 | 181
Liver Failure 3 | 73
Neonatal onset 3 | 21
Neuropathy 3 | 261
Peripheral Neuropathy 3 | 134
Steatorrhea 3 | 34
astrocytoma 3 | 1,146
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung carcinoma 3 | 2,843
medulloblastoma, large-cell 3 | 6,241
Adrenoleukodystrophy 2 | 29
Alkaline phosphatase serum increased 2 | 29
Atherosclerosis 2 | 291
Bipolar Disorder 2 | 666
Cerebellar Ataxia 2 | 304
Cholelithiasis 2 | 33
Chondrodysplasia punctata 2 | 41
Congenital bile acid synthesis defect 2 | 15
D-bifunctional protein deficiency 2 | 3
Depressive disorder 2 | 409
Dystonia 2 | 164
Epilepsy 2 | 792
Fatty liver disease 2 | 103
Hepatitis 2 | 67
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hypercholesterolemia 2 | 44
Hyperreflexia 2 | 209
Icterus 2 | 82
Increased bilirubin level (finding) 2 | 18
Liver Cirrhosis, Experimental 2 | 769
Liver diseases 2 | 87
Low Vision 2 | 174
Muscle Spasticity 2 | 195
Neonatal cholestatic liver disease 2 | 2
Osteoporosis 2 | 363
Peroxisomal acyl-CoA oxidase deficiency 2 | 4
Phenotypic variability 2 | 150
Primary hypogonadism 2 | 37
Prostatic Neoplasms 2 | 495
Pruritus 2 | 58
Refsum disease 2 | 20
Schizophrenia 2 | 1,160
Seizures 2 | 596
Serum cholesterol raised 2 | 22
Splenomegaly 2 | 190
Visual Impairment 2 | 174
Waldenstrons macroglobulinemia 2 | 765
Zellweger syndrome 2 | 37
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
chronic rhinosinusitis 2 | 512
hereditary spastic paraplegia 2 | 318
inflammatory breast cancer 2 | 286
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pediatric high grade glioma 2 | 1,064
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Metanephric adenoma 1 | 9
Oxyphilic adenoma 1 | 22

Tissue

Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Liver and Pancreas 17 | 16,750
Skin and soft tissues 17 | 17,230
Female tissues 16 | 17,400
Male tissues 16 | 17,142
Urinary Tract 16 | 16,678
Blood and immune system 15 | 16,909
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Cardiovascular System 12 | 15,192

Target Family

Enzyme 14 | 4,145
Non-IDG 2 | 12,091
Transporter 1 | 473

KEGG Pathway

Primary bile acid biosynthesis 17 | 17
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.65191 40.5 121
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.96016 6.61 126
Alpha-methylacyl-CoA racemase AMACR Tbio Enzyme -2.47448 310.5 545
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 Tbio Enzyme -1.87479 75.7 171
Non-specific lipid-transfer protein SCP2 Tchem Non-IDG -2.66328 485.4 314
25-hydroxycholesterol 7-alpha-hydroxylase CYP7B1 Tbio Enzyme -1.69377 48.1 203
Acyl-coenzyme A thioesterase 8 ACOT8 Tbio Enzyme -2.41856 254.6 180
3 beta-hydroxysteroid dehydrogenase type 7 HSD3B7 Tbio Enzyme -1.13969 12.9 112
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.17283 152.2 275