Development Level

Tbio 62 | 11,445
Tchem 42 | 1,598
Tclin 19 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 10 | 499
preweaning lethality, complete... 9 | 979
abnormal bone structure 5 | 187
increased heart weight 5 | 62
decreased body weight 4 | 161
increased startle reflex 4 | 112
abnormal behavior 3 | 298
decreased hematocrit 3 | 46
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
thrombocytopenia 3 | 56
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
hydrometra 2 | 53
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 36
increased monocyte cell number 2 | 63
small superior vagus ganglion 2 | 74
abnormal digit morphology 1 | 10
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged gallbladder 1 | 2
enlarged spleen 1 | 41
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
male infertility 1 | 123
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
small epididymis 1 | 3
small testis 1 | 58
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 102 | 11,493
osteosarcoma 74 | 7,950
ovarian cancer 69 | 8,520
glioblastoma 57 | 5,792
medulloblastoma, large-cell 56 | 6,241
psoriasis 51 | 6,694
Cancer 50 | 2,499
lung cancer 49 | 4,740
atypical teratoid / rhabdoid tumor 46 | 5,112
Kidney cancer 45 | 2,613
adult high grade glioma 44 | 3,801
ependymoma 41 | 4,679
Astrocytoma, Pilocytic 40 | 3,081
Breast cancer 37 | 3,578
pancreatic cancer 36 | 2,398
interstitial cystitis 34 | 2,312
lung adenocarcinoma 34 | 2,716
lung carcinoma 34 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
invasive ductal carcinoma 32 | 2,951
group 3 medulloblastoma 30 | 4,104
non-small cell lung cancer 30 | 2,890
ulcerative colitis 30 | 1,819
Autosomal recessive predisposition 29 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
primitive neuroectodermal tumor 29 | 3,035
subependymal giant cell astrocytoma 27 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
malignant mesothelioma 24 | 3,232
Schizophrenia 23 | 1,160
colon cancer 22 | 1,478
cystic fibrosis 21 | 1,696
group 4 medulloblastoma 21 | 1,855
oligodendroglioma 21 | 2,850
diabetes mellitus 20 | 1,728
juvenile dermatomyositis 20 | 1,187
tuberculosis 20 | 2,010
pituitary cancer 19 | 1,972
Hypertension 18 | 396
Liver Cirrhosis, Experimental 18 | 769
astrocytic glioma 18 | 2,597
Coronary artery disease 17 | 268
Pick disease 17 | 1,894
Waldenstrons macroglobulinemia 16 | 765
primary Sjogren syndrome 16 | 735
Bipolar Disorder 15 | 666
ductal carcinoma in situ 15 | 1,745
Cerebrovascular disease 14 | 238
Epistaxis 14 | 43
Hypertensive disease 14 | 292
astrocytoma 14 | 1,146
breast carcinoma 14 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Ecchymosis 13 | 66
Increased tendency to bruise 13 | 66
Osteoporosis 13 | 363
pancreatic carcinoma 13 | 562
spina bifida 13 | 1,074
Kidney disease 12 | 430
Liver cancer 12 | 604
Obesity 12 | 678
Rheumatoid arthritis 12 | 1,191
Short stature 12 | 531
Thrombocytopenia 12 | 197
adrenocortical carcinoma 12 | 1,428
gastric carcinoma 12 | 807
Epilepsy 11 | 792
Melanoma 11 | 711
cutaneous lupus erythematosus 11 | 1,057
esophageal adenocarcinoma 11 | 737
Arthritis 10 | 290
Asthma 10 | 385
Depressive disorder 10 | 409
Intellectual disability 10 | 1,016
Muscle hypotonia 10 | 571
Prostatic Neoplasms 10 | 495
Stomach Neoplasms 10 | 300
Vascular disease 10 | 319
acute quadriplegic myopathy 10 | 1,158
dermatomyositis 10 | 966
nasopharyngeal carcinoma 10 | 1,058
pediatric high grade glioma 10 | 1,064
primary pancreatic ductal adenocarcinoma 10 | 1,109
Alzheimer's disease 9 | 658
Atherosclerosis 9 | 291
Bleeding time prolonged 9 | 31
Breast Neoplasms 9 | 445
Dull intelligence 9 | 645
Glanzmann's thrombasthenia 9 | 23
Low intelligence 9 | 645
Mammary Neoplasms 9 | 425
Menorrhagia 9 | 25
Mental Depression 9 | 333
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Multiple myeloma 9 | 1,332
Poor school performance 9 | 645
Substance Withdrawal Syndrome 9 | 55
Crohn's disease 8 | 321
acute myeloid leukemia 8 | 783

Tissue

Blood and immune system 121 | 16,909
Digestive Tract 121 | 17,369
Endocrine System 121 | 18,159
Female tissues 120 | 17,400
Male tissues 120 | 17,142
Skin and soft tissues 120 | 17,230
Respiratory system 118 | 16,393
Liver and Pancreas 117 | 16,750
Urinary Tract 117 | 16,678
Nervous System 114 | 16,725
Cardiovascular System 113 | 15,192

Target Family

Non-IDG 44 | 12,091
Enzyme 38 | 4,145
Kinase 32 | 634
GPCR 6 | 408
Ion Channel 5 | 344

KEGG Pathway

Platelet activation 125 | 125
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Proteinase-activated receptor 4 F2RL3 Tchem GPCR -1.50044 34.1 276
Talin-2 TLN2 Tbio Non-IDG -1.36153 20.0 101
Cytosolic phospholipase A2 gamma PLA2G4C Tchem Enzyme -1.27690 20.9 63
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733