Development Level

Tbio 66 | 10,625
Tchem 59 | 1,890
Tclin 17 | 602
Tdark 3 | 7,003

Collection

Kinase: IDG Consortium (Targets) 2 | 125
GPCR: IDG Consortium (Targets) 1 | 127
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 7 | 633
abnormal bone mineralization 6 | 55
increased heart weight 5 | 37
abnormal bone structure 4 | 131
decreased body weight 4 | 174
increased mean corpuscular hem... 4 | 93
preweaning lethality, incomple... 4 | 260
cataract 2 | 26
decreased NK T cell number 2 | 28
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased lumbar vertebrae num... 2 | 62
decreased mature B cell number 2 | 25
decreased mean corpuscular vol... 2 | 50
embryonic lethality prior to t... 2 | 187
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
abnormal behavior 1 | 226
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal lens morphology 1 | 73
abnormal respiratory quotient 1 | 9
abnormal seminal vesicle morph... 1 | 47
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
decreased B cell number 1 | 30
decreased CD8-positive, alpha-... 1 | 26
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating thyroxin... 1 | 5
decreased dendritic cell numbe... 1 | 3
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lactate dehydrogenas... 1 | 14
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
enlarged spleen 1 | 26
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired pupillary reflex 1 | 14
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased IgG1 level 1 | 1
increased KLRG1-positive gamma... 1 | 2
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating calcium ... 1 | 32
increased circulating creatini... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased effector memory CD8-... 1 | 14
increased effector memory T-he... 1 | 5
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart rate variabili... 1 | 4
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 25
increased monocyte cell number 1 | 27
increased myeloid cell number 1 | 2
increased sacral vertebrae num... 1 | 62
increased thoracic vertebrae n... 1 | 8
increased total body fat amoun... 1 | 57
male infertility 1 | 62
mydriasis 1 | 9
thrombocytosis 1 | 23

Disease

osteosarcoma 84 | 7,933
ovarian cancer 77 | 8,491
medulloblastoma, large-cell 69 | 6,234
glioblastoma 66 | 5,572
Cancer 65 | 2,346
psoriasis 64 | 6,685
atypical teratoid / rhabdoid tumor 48 | 4,369
lung cancer 48 | 4,473
Carcinoma 46 | 2,147
lung carcinoma 45 | 2,844
invasive ductal carcinoma 42 | 2,950
Breast cancer 41 | 3,098
malignant mesothelioma 39 | 3,163
pilocytic astrocytoma 39 | 3,086
ependymoma 36 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
pancreatic cancer 34 | 2,300
primitive neuroectodermal tumor 34 | 3,031
group 4 medulloblastoma 31 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,988
pediatric high grade glioma 31 | 2,712
subependymal giant cell astrocytoma 31 | 2,287
lung adenocarcinoma 30 | 2,714
oligodendroglioma 30 | 2,849
ulcerative colitis 30 | 2,087
interstitial cystitis 28 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
non-small cell lung cancer 28 | 2,798
adult high grade glioma 26 | 2,148
astrocytic glioma 25 | 2,241
pituitary cancer 24 | 1,972
ductal carcinoma in situ 23 | 1,745
diabetes mellitus 22 | 1,663
Pick disease 21 | 1,893
Schizophrenia 21 | 503
astrocytoma 21 | 1,493
cystic fibrosis 20 | 1,670
medulloblastoma 20 | 1,524
breast carcinoma 18 | 1,614
tuberculosis 18 | 1,563
adrenocortical carcinoma 17 | 1,427
colon cancer 17 | 1,475
juvenile dermatomyositis 17 | 1,189
Kidney disease 16 | 397
primary pancreatic ductal adenocarcinoma 16 | 1,271
sonic hedgehog group medulloblastoma 16 | 1,482
Alzheimer's disease 14 | 644
Asthma 14 | 349
Obesity 14 | 616
esophageal adenocarcinoma 14 | 737
non-small cell lung carcinoma 14 | 413
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
primary Sjogren syndrome 14 | 788
Autistic Disorder 13 | 320
Epilepsy 13 | 346
Mammary Neoplasms 13 | 410
cutaneous lupus erythematosus 13 | 1,056
pancreatic carcinoma 13 | 567
posterior fossa group A ependymoma 13 | 1,511
Intellectual disability 12 | 573
Kidney cancer 12 | 121
Multiple myeloma 12 | 1,327
Rheumatoid Arthritis 12 | 1,170
group 3 medulloblastoma 12 | 2,254
Stomach Neoplasms 11 | 282
atypical teratoid/rhabdoid tumor 11 | 1,095
dermatomyositis 11 | 966
posterior fossa group B ependymoma 11 | 1,530
spina bifida 11 | 1,064
Adenoma 10 | 165
Heart disease 10 | 279
Melanoma 10 | 261
Noonan Syndrome 10 | 33
Prostatic Neoplasms 10 | 471
Squamous cell carcinoma 10 | 96
Vascular disease 10 | 281
acute quadriplegic myopathy 10 | 1,157
Atherosclerosis 9 | 275
Atopic dermatitis 9 | 944
Bipolar Disorder 9 | 266
Liver carcinoma 9 | 217
Parkinson's disease 9 | 364
Polycystic Ovary Syndrome 9 | 334
Substance Withdrawal Syndrome 9 | 55
mucosa-associated lymphoid tissue lymphoma 9 | 480
ovarian neoplasm 9 | 97
Diarrhea 8 | 155
Lung Neoplasms 8 | 171
Renal Cell Carcinoma 8 | 199
active Crohn's disease 8 | 918
acute myeloid leukemia 8 | 785
gastric carcinoma 8 | 832
nasopharyngeal carcinoma 8 | 1,056
progressive supranuclear palsy 8 | 674
Arthritis 7 | 248
Cerebrovascular disease 7 | 231
Coronary artery disease 7 | 240
Down syndrome 7 | 548
Waldenstrons macroglobulinemia 7 | 764
hepatocellular carcinoma 7 | 550

Tissue

Cardiovascular System 144 | 17,957
Liver and Pancreas 144 | 18,135
Nervous System 144 | 18,560
Blood and immune system 143 | 17,994
Digestive Tract 143 | 18,472
Endocrine System 143 | 18,511
Female tissues 143 | 18,646
Urinary Tract 143 | 18,443
Male tissues 142 | 17,968
Respiratory system 142 | 17,483
Skin and soft tissues 141 | 18,114

Target Family

Enzyme 54 | 4,146
Non-IDG 39 | 11,969
Kinase 30 | 634
GPCR 22 | 408

KEGG Pathway

Phospholipase D signaling path... 145 | 145
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.45436 257.8 324
Dynamin-3 DNM3 Tbio Non-IDG -1.39919 21.9 126
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.86049 63.7 252
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.39396 233.2 634
Diacylglycerol kinase beta DGKB Tbio Enzyme -1.47965 35.3 115
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.12987 136.7 95
Proteinase-activated receptor 1 F2R Tclin GPCR -2.76897 534.6 399
Vasopressin-neurophysin 2-copeptin AVP Tbio Non-IDG -3.91847 8071.2 168