Development Level

Tbio 78 | 11,651
Tchem 49 | 1,388
Tclin 18 | 612
Tdark 2 | 6,593

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 6 | 499
abnormal bone structure 5 | 187
decreased total body fat amoun... 5 | 207
increased heart weight 5 | 62
decreased body weight 4 | 161
increased startle reflex 4 | 112
increased total body fat amoun... 4 | 134
decreased mean corpuscular vol... 3 | 79
embryonic lethality prior to t... 3 | 278
increased lean body mass 3 | 172
abnormal bone mineralization 2 | 38
abnormal gait 2 | 69
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating LDL chol... 2 | 13
increased circulating choleste... 2 | 66
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased mean corpuscular hem... 2 | 96
abnormal behavior 1 | 298
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased neutrophil cell numb... 1 | 42
decreased urine magnesium leve... 1 | 3
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
mydriasis 1 | 6
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Carcinoma 118 | 11,493
osteosarcoma 85 | 7,950
ovarian cancer 80 | 8,520
glioblastoma 69 | 5,792
medulloblastoma, large-cell 69 | 6,241
Cancer 67 | 2,499
psoriasis 65 | 6,694
lung cancer 61 | 4,740
atypical teratoid / rhabdoid tumor 55 | 5,112
ependymoma 54 | 4,679
Breast cancer 47 | 3,578
Kidney cancer 47 | 2,613
lung carcinoma 45 | 2,843
adult high grade glioma 44 | 3,801
group 3 medulloblastoma 43 | 4,104
invasive ductal carcinoma 42 | 2,951
malignant mesothelioma 42 | 3,232
Astrocytoma, Pilocytic 37 | 3,081
pancreatic cancer 35 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
primitive neuroectodermal tumor 34 | 3,035
Schizophrenia 33 | 1,160
astrocytic glioma 32 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
subependymal giant cell astrocytoma 31 | 2,287
lung adenocarcinoma 30 | 2,716
non-small cell lung cancer 30 | 2,890
oligodendroglioma 30 | 2,850
interstitial cystitis 28 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
ulcerative colitis 27 | 1,819
Epilepsy 26 | 792
group 4 medulloblastoma 26 | 1,855
pituitary cancer 24 | 1,972
diabetes mellitus 23 | 1,728
ductal carcinoma in situ 23 | 1,745
tuberculosis 23 | 2,010
Bipolar Disorder 21 | 666
Pick disease 21 | 1,894
breast carcinoma 21 | 1,638
cystic fibrosis 21 | 1,696
Autosomal recessive predisposition 20 | 1,442
Intellectual disability 19 | 1,016
Melanoma 19 | 711
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Seizures 17 | 596
adrenocortical carcinoma 17 | 1,428
colon cancer 17 | 1,478
juvenile dermatomyositis 17 | 1,187
Dull intelligence 16 | 645
Kidney disease 16 | 430
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
Blepharoptosis 15 | 231
Liver cancer 15 | 604
Obesity 15 | 678
Orbital separation excessive 15 | 244
Stomach Neoplasms 15 | 300
astrocytoma 15 | 1,146
Alcoholic Intoxication, Chronic 14 | 289
Asthma 14 | 385
Breast Neoplasms 14 | 445
Cognitive delay 14 | 608
Depressive disorder 14 | 409
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Muscle hypotonia 14 | 571
Short stature 14 | 531
Skin cancer 14 | 469
esophageal adenocarcinoma 14 | 737
primary Sjogren syndrome 14 | 735
Mammary Neoplasms 13 | 425
Unipolar Depression 13 | 250
cutaneous lupus erythematosus 13 | 1,057
pancreatic carcinoma 13 | 562
pediatric high grade glioma 13 | 1,064
Alzheimer's disease 12 | 658
Autistic Disorder 12 | 364
Byzanthine arch palate 12 | 194
Concave bridge of nose 12 | 195
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Downward slant of palpebral fissure 12 | 158
Hypoplastic mandible condyle 12 | 275
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Multiple myeloma 12 | 1,332
Rheumatoid arthritis 12 | 1,191
primary pancreatic ductal adenocarcinoma 12 | 1,109
Dysarthria 11 | 192
Heart disease 11 | 306
Hepatomegaly 11 | 285
Hypothyroidism 11 | 122
Major Depressive Disorder 11 | 301
Mental Depression 11 | 333
Polycystic ovary syndrome 11 | 360
dermatomyositis 11 | 966
spina bifida 11 | 1,074

Tissue

Endocrine System 144 | 18,159
Skin and soft tissues 142 | 17,230
Female tissues 141 | 17,400
Digestive Tract 140 | 17,369
Nervous System 140 | 16,725
Urinary Tract 140 | 16,678
Blood and immune system 138 | 16,909
Male tissues 138 | 17,142
Liver and Pancreas 137 | 16,750
Respiratory system 137 | 16,393
Cardiovascular System 133 | 15,192

Target Family

Enzyme 55 | 4,145
Non-IDG 39 | 12,091
Kinase 31 | 634
GPCR 22 | 408

KEGG Pathway

Phospholipase D signaling path... 147 | 147
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Metabotropic glutamate receptor 2 GRM2 Tchem GPCR -2.77035 612.3 315
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha AGPAT1 Tbio Enzyme -1.04175 10.1 88
SHC-transforming protein 4 SHC4 Tbio Non-IDG -2.45096 295.5 129
Vasopressin-neurophysin 2-copeptin AVP Tbio Non-IDG -3.92570 8381.2 203
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978