Development Level

Tbio 63 | 11,445
Tchem 26 | 1,598
Tclin 6 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 6 | 125
RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 5 | 220
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 5 | 499
embryonic growth retardation 4 | 106
embryonic lethality prior to o... 4 | 239
abnormal gait 3 | 69
decreased body weight 3 | 161
increased lean body mass 3 | 172
abnormal neural tube closure 2 | 46
decreased circulating creatini... 2 | 39
decreased total body fat amoun... 2 | 207
edema 2 | 59
persistence of hyaloid vascula... 2 | 33
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal forebrain morphology 1 | 10
abnormal gallbladder morpholog... 1 | 1
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal midbrain morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
anophthalmia 1 | 33
decreased IgG3 level 1 | 1
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
hypoactivity 1 | 132
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
microphthalmia 1 | 26
polydactyly 1 | 7
small epididymis 1 | 3
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 78 | 11,493
osteosarcoma 53 | 7,950
ovarian cancer 53 | 8,520
medulloblastoma, large-cell 48 | 6,241
ependymoma 43 | 4,679
glioblastoma 43 | 5,792
psoriasis 41 | 6,694
atypical teratoid / rhabdoid tumor 37 | 5,112
lung cancer 36 | 4,740
adult high grade glioma 34 | 3,801
group 3 medulloblastoma 31 | 4,104
Kidney cancer 28 | 2,613
primitive neuroectodermal tumor 28 | 3,035
Astrocytoma, Pilocytic 26 | 3,081
Breast cancer 26 | 3,578
lung carcinoma 24 | 2,843
oligodendroglioma 24 | 2,850
subependymal giant cell astrocytoma 23 | 2,287
Pick disease 21 | 1,894
astrocytic glioma 19 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
malignant mesothelioma 19 | 3,232
Schizophrenia 18 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
lung adenocarcinoma 16 | 2,716
ulcerative colitis 16 | 1,819
Autosomal recessive predisposition 15 | 1,442
Cancer 15 | 2,499
invasive ductal carcinoma 15 | 2,951
colon cancer 14 | 1,478
diabetes mellitus 14 | 1,728
group 4 medulloblastoma 14 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
pancreatic cancer 13 | 2,398
pituitary cancer 13 | 1,972
tuberculosis 13 | 2,010
Bipolar Disorder 12 | 666
non-small cell lung cancer 12 | 2,890
interstitial cystitis 11 | 2,312
Epilepsy 10 | 792
Intellectual disability 10 | 1,016
Rheumatoid arthritis 10 | 1,191
astrocytoma 10 | 1,146
Oculocerebrorenal syndrome 9 | 29
Waldenstrons macroglobulinemia 9 | 765
acute quadriplegic myopathy 9 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
spina bifida 9 | 1,074
Centronuclear myopathy 8 | 27
Liver cancer 8 | 604
juvenile dermatomyositis 8 | 1,187
Melanoma 7 | 711
Seizures 7 | 596
cutaneous lupus erythematosus 7 | 1,057
cystic fibrosis 7 | 1,696
gastric carcinoma 7 | 807
nasopharyngeal carcinoma 7 | 1,058
Acquired scoliosis 6 | 281
Curvature of spine 6 | 282
Frontal bossing 6 | 157
Heart disease 6 | 306
active Crohn's disease 6 | 922
atypical teratoid/rhabdoid tumor 6 | 357
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
primary Sjogren syndrome 6 | 735
Alzheimer's disease 5 | 658
Big calvaria 5 | 147
Cataract 5 | 297
Cognitive delay 5 | 608
DOID:2627 5 | 94
Depressive disorder 5 | 409
Dull intelligence 5 | 645
Endometrial cancer 5 | 311
Global developmental delay 5 | 608
Hypertension 5 | 396
Hypoplastic mandible condyle 5 | 275
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Low intelligence 5 | 645
Mandibular hypoplasia 5 | 275
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Micrognathism 5 | 275
Multiple myeloma 5 | 1,332
Muscle hypotonia 5 | 571
Parkinson's disease 5 | 392
Poor school performance 5 | 645
Skin cancer 5 | 469
aldosterone-producing adenoma 5 | 665
breast carcinoma 5 | 1,638
fibroadenoma 5 | 559
medulloblastoma 5 | 720
progressive supranuclear palsy 5 | 676
Crohn's disease 4 | 321
Prostatic Neoplasms 4 | 495
acute myeloid leukemia 4 | 783
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Endocrine System 99 | 18,159
Digestive Tract 98 | 17,369
Female tissues 98 | 17,400
Liver and Pancreas 98 | 16,750
Male tissues 98 | 17,142
Skin and soft tissues 98 | 17,230
Nervous System 97 | 16,725
Blood and immune system 95 | 16,909
Respiratory system 95 | 16,393
Cardiovascular System 94 | 15,192
Urinary Tract 94 | 16,678

Target Family

Enzyme 55 | 4,145
Kinase 32 | 634
Non-IDG 9 | 12,091
Ion Channel 3 | 344

KEGG Pathway

Phosphatidylinositol signaling... 99 | 99
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Type I inositol 3,4-bisphosphate 4-phosphatase INPP4A Tbio Enzyme -1.12941 13.9 47
Myotubularin-related protein 3 MTMR3 Tbio Enzyme -1.05980 10.7 33
Myotubularin-related protein 1 MTMR1 Tbio Enzyme -0.89579 6.93 82
Diacylglycerol kinase eta DGKH Tbio Kinase -1.45863 29.5 92
Myotubularin-related protein 4 MTMR4 Tbio Enzyme -0.76288 7.50 138
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 PPIP5K2 Tbio Enzyme -1.29036 17.0 49
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Calmodulin-like protein 5 CALML5 Tbio Non-IDG -1.32968 24.4 111
Diacylglycerol kinase epsilon DGKE Tbio Enzyme -1.62076 41.9 159