Development Level

Tbio 62 | 10,625
Tchem 27 | 1,890
Tdark 5 | 7,003
Tclin 3 | 602

Collection

Eligible Kinase Proteins 9 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased body weight 5 | 174
preweaning lethality, complete... 5 | 633
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
decreased circulating creatini... 2 | 31
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
increased body weight 2 | 42
abnormal QRS complex 1 | 25
abnormal bone mineralization 1 | 55
abnormal gait 1 | 51
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
absent heartbeat 1 | 6
decreased B cell number 1 | 30
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating lactate ... 1 | 1
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mature B cell number 1 | 25
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased IgG1 level 1 | 1
increased T cell number 1 | 15
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased neutrophil cell numb... 1 | 15
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
small epididymis 1 | 3
tremors 1 | 34

Disease

osteosarcoma 53 | 7,933
ovarian cancer 50 | 8,484
medulloblastoma, large-cell 46 | 6,234
psoriasis 40 | 6,685
glioblastoma 38 | 5,572
lung cancer 36 | 4,466
atypical teratoid / rhabdoid tumor 31 | 4,369
lung carcinoma 26 | 2,844
pilocytic astrocytoma 26 | 3,086
primitive neuroectodermal tumor 26 | 3,031
subependymal giant cell astrocytoma 24 | 2,287
Breast cancer 23 | 3,094
Carcinoma 23 | 2,147
ependymoma 23 | 2,514
oligodendroglioma 22 | 2,849
ulcerative colitis 20 | 2,087
Pick disease 19 | 1,893
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
pediatric high grade glioma 19 | 2,712
adult high grade glioma 18 | 2,148
group 4 medulloblastoma 17 | 1,875
invasive ductal carcinoma 17 | 2,950
malignant mesothelioma 17 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
lung adenocarcinoma 16 | 2,713
astrocytic glioma 14 | 2,241
astrocytoma 14 | 1,493
colon cancer 14 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
Cancer 13 | 2,346
interstitial cystitis 13 | 2,299
pancreatic cancer 13 | 2,300
group 3 medulloblastoma 12 | 2,254
non-small cell lung cancer 12 | 2,798
pituitary cancer 12 | 1,972
posterior fossa group A ependymoma 12 | 1,511
posterior fossa group B ependymoma 12 | 1,530
sonic hedgehog group medulloblastoma 12 | 1,482
Schizophrenia 11 | 501
atypical teratoid/rhabdoid tumor 11 | 1,095
diabetes mellitus 11 | 1,663
Rheumatoid Arthritis 10 | 1,160
medulloblastoma 10 | 1,524
spina bifida 10 | 1,064
acute quadriplegic myopathy 9 | 1,157
Centronuclear myopathy 8 | 21
Oculocerebrorenal syndrome 8 | 23
Waldenstrons macroglobulinemia 8 | 765
juvenile dermatomyositis 8 | 1,189
primary Sjogren syndrome 8 | 789
tuberculosis 8 | 1,557
Bipolar Disorder 7 | 266
cutaneous lupus erythematosus 7 | 1,056
cystic fibrosis 7 | 1,665
gastric carcinoma 7 | 832
nasopharyngeal carcinoma 7 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
Intellectual disability 6 | 573
ductal carcinoma in situ 6 | 1,745
esophageal adenocarcinoma 6 | 737
primary pancreatic ductal adenocarcinoma 6 | 1,271
Autistic Disorder 5 | 320
IGA Glomerulonephritis 5 | 454
Kidney cancer 5 | 118
Multiple myeloma 5 | 1,327
Neurodegenerative disease 5 | 383
Parkinson's disease 5 | 364
active Crohn's disease 5 | 918
fibroadenoma 5 | 557
glioblastoma multiforme 5 | 347
progressive supranuclear palsy 5 | 674
Cardiomegaly 4 | 66
Crohn's disease 4 | 304
Diffuse large B-cell lymphoma 4 | 41
Heart disease 4 | 279
Obesity 4 | 616
Prostatic Neoplasms 4 | 471
acute myeloid leukemia 4 | 780
aldosterone-producing adenoma 4 | 664
dermatomyositis 4 | 933
pancreatic carcinoma 4 | 567
tuberculosis and treatment for 6 months 4 | 686
Adenocarcinoma 3 | 115
Alzheimer's disease 3 | 644
Amyotrophic Lateral Sclerosis 3 | 431
Cerebrovascular disease 3 | 231
Down syndrome 3 | 548
Endometrial cancer 3 | 25
Gaucher disease type 1 3 | 171
Long QT syndrome 3 | 52
Mammary Neoplasms 3 | 410
Melanoma 3 | 261
Stomach Neoplasms 3 | 282
adrenocortical carcinoma 3 | 1,427
breast carcinoma 3 | 1,614
head and neck cancer 3 | 270
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung carcinoma 3 | 413
periodontitis 3 | 269
tuberculosis and treatment for 3 months 3 | 327

Tissue

Blood and immune system 97 | 17,995
Cardiovascular System 97 | 17,958
Liver and Pancreas 97 | 18,136
Nervous System 97 | 18,561
Digestive Tract 96 | 18,473
Endocrine System 96 | 18,512
Female tissues 96 | 18,647
Male tissues 96 | 17,969
Urinary Tract 96 | 18,444
Respiratory system 95 | 17,484
Skin and soft tissues 95 | 18,115

Target Family

Enzyme 54 | 4,146
Kinase 33 | 634
Non-IDG 7 | 11,971
Ion Channel 3 | 341

KEGG Pathway

Phosphatidylinositol signaling... 97 | 97
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Inositol-trisphosphate 3-kinase B ITPKB Tbio Kinase -1.40405 29.1 141
Inositol polyphosphate 1-phosphatase INPP1 Tbio Enzyme -1.22269 17.2 73
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.16125 137.5 96
Inositol polyphosphate multikinase IPMK Tbio Kinase -1.49619 35.9 131
Diacylglycerol kinase gamma DGKG Tbio Enzyme -1.22622 18.8 58
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.26683 181.8 641
Synaptojanin-2 SYNJ2 Tbio Non-IDG -1.14204 16.3 154
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.37849 233.2 634
Diacylglycerol kinase beta DGKB Tbio Enzyme -1.49580 35.3 115