Development Level

Tbio 294 | 11,445
Tchem 139 | 1,598
Tclin 86 | 613
Tdark 11 | 6,588

Collection

GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 44 | 979
preweaning lethality, incomple... 15 | 499
embryonic lethality prior to t... 13 | 278
enlarged heart 11 | 210
increased startle reflex 11 | 112
decreased body weight 9 | 161
decreased mean corpuscular vol... 9 | 79
decreased total body fat amoun... 9 | 207
increased lean body mass 9 | 172
abnormal embryo size 8 | 220
decreased hematocrit 8 | 46
decreased vertical activity 8 | 208
increased total body fat amoun... 8 | 134
abnormal bone structure 7 | 187
abnormal heart morphology 7 | 162
cataract 7 | 92
male infertility 7 | 123
abnormal lens morphology 6 | 81
decreased hemoglobin content 6 | 68
embryonic lethality prior to o... 6 | 239
impaired glucose tolerance 6 | 75
increased circulating choleste... 6 | 66
increased heart weight 6 | 62
increased hemoglobin content 6 | 45
short tibia 6 | 97
small superior vagus ganglion 6 | 74
abnormal gait 5 | 69
abnormal retina morphology 5 | 71
decreased bone mineral content 5 | 151
decreased erythrocyte cell num... 5 | 62
decreased prepulse inhibition 5 | 82
enlarged lymph nodes 5 | 37
hyperactivity 5 | 148
limb grasping 5 | 41
abnormal behavior 4 | 298
abnormal bone mineralization 4 | 38
abnormal spleen morphology 4 | 55
decreased circulating choleste... 4 | 93
decreased circulating triglyce... 4 | 79
decreased lean body mass 4 | 135
decreased lymphocyte cell numb... 4 | 83
edema 4 | 59
female infertility 4 | 60
improved glucose tolerance 4 | 79
increased blood urea nitrogen ... 4 | 48
increased bone mineral content 4 | 108
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
increased mean corpuscular hem... 4 | 96
increased mean corpuscular hem... 4 | 36
increased monocyte cell number 4 | 63
increased neutrophil cell numb... 4 | 46
persistence of hyaloid vascula... 4 | 33
abnormal eye morphology 3 | 68
abnormal kidney morphology 3 | 65
abnormal retinal vasculature m... 3 | 27
abnormal seminal vesicle morph... 3 | 114
abnormal startle reflex 3 | 15
decreased circulating amylase ... 3 | 28
decreased circulating creatini... 3 | 39
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased fasted circulating g... 3 | 65
embryonic growth retardation 3 | 106
hydrometra 3 | 53
increased bone mineral density 3 | 72
increased circulating amylase ... 3 | 25
increased circulating triglyce... 3 | 42
increased erythrocyte cell num... 3 | 39
increased fasted circulating g... 3 | 76
increased leukocyte cell numbe... 3 | 47
microphthalmia 3 | 26
prenatal lethality 3 | 28
prenatal lethality prior to he... 3 | 87
abnormal body wall morphology 2 | 9
abnormal coat-hair pigmentatio... 2 | 64
abnormal cornea morphology 2 | 31
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal skin morphology 2 | 50
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 18
corneal opacity 2 | 32
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating chloride... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased mean corpuscular hem... 2 | 31
decreased spleen weight 2 | 10
decreased startle reflex 2 | 75
enlarged kidney 2 | 14
enlarged spleen 2 | 41
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
increased body weight 2 | 25
increased circulating calcium ... 2 | 34
small testis 2 | 58
vertebral fusion 2 | 23

Disease

Carcinoma 377 | 11,493
Cancer 343 | 2,499
ovarian cancer 310 | 8,520
osteosarcoma 276 | 7,950
psoriasis 256 | 6,694
glioblastoma 237 | 5,792
lung cancer 230 | 4,740
medulloblastoma, large-cell 216 | 6,241
atypical teratoid / rhabdoid tumor 198 | 5,112
Breast cancer 191 | 3,578
malignant mesothelioma 181 | 3,232
ependymoma 171 | 4,679
group 3 medulloblastoma 147 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 138 | 3,291
Kidney cancer 133 | 2,613
invasive ductal carcinoma 129 | 2,951
lung carcinoma 127 | 2,843
Astrocytoma, Pilocytic 126 | 3,081
pancreatic cancer 126 | 2,398
non-small cell lung cancer 125 | 2,890
adult high grade glioma 119 | 3,801
oligodendroglioma 116 | 2,850
primitive neuroectodermal tumor 115 | 3,035
lung adenocarcinoma 111 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 108 | 2,989
interstitial cystitis 107 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 106 | 2,955
Schizophrenia 101 | 1,160
Breast Neoplasms 99 | 445
Mammary Neoplasms 98 | 425
tuberculosis 95 | 2,010
astrocytic glioma 94 | 2,597
subependymal giant cell astrocytoma 94 | 2,287
ulcerative colitis 94 | 1,819
breast carcinoma 90 | 1,638
cystic fibrosis 90 | 1,696
diabetes mellitus 88 | 1,728
Autosomal recessive predisposition 83 | 1,442
Prostatic Neoplasms 83 | 495
ductal carcinoma in situ 82 | 1,745
pituitary cancer 80 | 1,972
Rheumatoid arthritis 75 | 1,191
colon cancer 72 | 1,478
adrenocortical carcinoma 66 | 1,428
Liver carcinoma 65 | 240
astrocytoma 65 | 1,146
group 4 medulloblastoma 63 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 63 | 1,962
Carcinoma, Hepatocellular 62 | 228
Melanoma 60 | 711
juvenile dermatomyositis 60 | 1,187
Lung Neoplasms 59 | 232
Pick disease 58 | 1,894
cutaneous lupus erythematosus 58 | 1,057
Intellectual disability 57 | 1,016
Stomach Neoplasms 57 | 300
Multiple myeloma 56 | 1,332
Liver Cirrhosis, Experimental 55 | 769
Short stature 55 | 531
pediatric high grade glioma 55 | 1,064
primary pancreatic ductal adenocarcinoma 55 | 1,109
Kidney disease 54 | 430
Vascular disease 54 | 319
acute quadriplegic myopathy 54 | 1,158
Epilepsy 53 | 792
Obesity 53 | 678
Hypertension 52 | 396
Bipolar Disorder 51 | 666
Renal Cell Carcinoma 51 | 214
nasopharyngeal carcinoma 50 | 1,058
Depressive disorder 49 | 409
Seizures 49 | 596
Orbital separation excessive 48 | 244
Colorectal Neoplasms 47 | 243
Endometriosis 47 | 540
Hypertensive disease 47 | 292
Neoplasm Metastasis 47 | 168
dermatomyositis 47 | 966
Asthma 46 | 385
medulloblastoma 46 | 720
Adenoma 45 | 167
Dull intelligence 45 | 645
Low intelligence 45 | 645
Mental Retardation 45 | 645
Mental deficiency 45 | 645
Poor school performance 45 | 645
non-small cell lung carcinoma 45 | 317
Atopic dermatitis 44 | 952
Cognitive delay 44 | 608
Global developmental delay 44 | 608
Mental and motor retardation 44 | 608
Osteoporosis 44 | 363
esophageal adenocarcinoma 44 | 737
Arthritis 43 | 290
Anemia 42 | 365
Heart disease 42 | 306
Liver cancer 42 | 604
Alzheimer's disease 41 | 658
Cleft Palate 40 | 271
acute myeloid leukemia 40 | 783

Tissue

Endocrine System 506 | 18,159
Digestive Tract 501 | 17,369
Blood and immune system 500 | 16,909
Male tissues 500 | 17,142
Female tissues 497 | 17,400
Skin and soft tissues 496 | 17,230
Nervous System 492 | 16,725
Urinary Tract 491 | 16,678
Liver and Pancreas 489 | 16,750
Respiratory system 485 | 16,393
Cardiovascular System 461 | 15,192

Target Family

Non-IDG 281 | 12,091
Enzyme 82 | 4,145
Kinase 70 | 634
Transcription Factor 49 | 1,400
GPCR 29 | 408
Nuclear Receptor 10 | 48
Epigenetic 7 | 242
TF/Epigenetic 1 | 38
Transporter 1 | 473

KEGG Pathway

Pathways in cancer 530 | 530
Metabolic pathways 1,263 | 1,263
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hedgehog-interacting protein HHIP Tbio Non-IDG -1.83526 65.4 193
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Proteinase-activated receptor 4 F2RL3 Tchem GPCR -1.50044 34.1 276
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092