Development Level

Tbio 61 | 10,625
Tclin 52 | 602
Tchem 19 | 1,890
Tdark 10 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 14 | 633
embryonic lethality prior to o... 6 | 148
abnormal behavior 5 | 226
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
embryonic lethality prior to t... 3 | 187
increased heart weight 3 | 37
pallor 3 | 13
short tibia 3 | 82
abnormal skin coloration 2 | 18
cardiovascular system phenotyp... 2 | 35
decreased bone mineral content 2 | 157
decreased effector memory CD8-... 2 | 24
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
hyperactivity 2 | 108
improved glucose tolerance 2 | 56
increased circulating alkaline... 2 | 119
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 68
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal embryo turning 1 | 15
abnormal foot plate morphology 1 | 2
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal retina morphology 1 | 100
abnormal skin appearance 1 | 8
abnormal spine curvature 1 | 7
abnormal spleen morphology 1 | 36
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 2
absent teeth 1 | 4
decreased Ly6C-positive mature... 1 | 4
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased heart weight 1 | 44
decreased lactate dehydrogenas... 1 | 14
decreased lean body mass 1 | 195
decreased mean platelet volume 1 | 12
decreased rib number 1 | 59
decreased startle reflex 1 | 48
hypoactivity 1 | 89
increased CD11b-high dendritic... 1 | 5
increased CD4-positive, CD25-p... 1 | 18
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased circulating calcium ... 1 | 32
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased dendritic cell numbe... 1 | 2
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
pale liver 1 | 5
prenatal lethality 1 | 16
small liver 1 | 8
small spleen 1 | 11
thrombocytopenia 1 | 46

Disease

ovarian cancer 79 | 8,484
Multiple myeloma 53 | 1,327
Diabetes mellitus type 2 46 | 69
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
osteosarcoma 45 | 7,933
psoriasis 39 | 6,685
lung cancer 38 | 4,466
medulloblastoma, large-cell 30 | 6,234
Leigh disease 29 | 81
glioblastoma 28 | 5,572
Parkinson's disease 25 | 364
atypical teratoid / rhabdoid tumor 25 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,795
MITOCHONDRIAL COMPLEX I DEFICIENCY 22 | 37
Breast cancer 21 | 3,094
Waldenstrons macroglobulinemia 20 | 765
oligodendroglioma 20 | 2,849
astrocytic glioma 19 | 2,241
astrocytoma 19 | 1,493
ependymoma 19 | 2,514
diabetes mellitus 16 | 1,663
Alzheimer's disease 15 | 644
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
ulcerative colitis 15 | 2,087
pilocytic astrocytoma 14 | 3,086
Cancer 13 | 2,346
NADH:Q(1) Oxidoreductase deficiency 13 | 20
Neurodegenerative disease 13 | 383
pediatric high grade glioma 13 | 2,712
Leber hereditary optic neuropathy 12 | 17
Pick disease 12 | 1,893
medulloblastoma 12 | 1,524
non primary Sjogren syndrome sicca 12 | 840
primitive neuroectodermal tumor 12 | 3,031
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 11 | 14
Mitochondrial myopathy 11 | 23
breast carcinoma 11 | 1,614
colon cancer 11 | 1,475
group 3 medulloblastoma 11 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
lung adenocarcinoma 11 | 2,713
Optic Atrophy, Hereditary, Leber 10 | 14
Schizophrenia 10 | 501
adult high grade glioma 10 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
lung carcinoma 10 | 2,844
Parkinson Disease 9 | 102
invasive ductal carcinoma 9 | 2,950
malignant mesothelioma 9 | 3,162
non-small cell lung cancer 9 | 2,798
Dystonia 8 | 77
Obesity 8 | 616
Rheumatoid Arthritis 8 | 1,160
Toxic encephalopathy 8 | 131
acute myeloid leukemia 8 | 780
Down syndrome 7 | 548
Lactic acidosis 7 | 42
Nerve Degeneration 7 | 73
Neuropathy 7 | 210
Parkinsonian Disorders 7 | 23
acute quadriplegic myopathy 7 | 1,157
aldosterone-producing adenoma 7 | 664
interstitial cystitis 7 | 2,299
pituitary cancer 7 | 1,972
tuberculosis 7 | 1,557
Bipolar Disorder 6 | 266
Brain disease 6 | 83
Dementia 6 | 129
Huntington's disease 6 | 72
MELAS syndrome 6 | 17
Multiple system atrophy 6 | 27
dermatomyositis 6 | 933
glioblastoma multiforme 6 | 347
pancreatic cancer 6 | 2,300
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis and treatment for 6 months 6 | 686
Amphetamine-Related Disorders 5 | 74
Attention deficit hyperactivity disorder 5 | 156
Cardiomyopathies 5 | 90
Crohn's disease 5 | 304
Duchenne muscular dystrophy 5 | 602
Hyperactive behavior 5 | 31
PARKINSON DISEASE, LATE-ONSET 5 | 18
Pneumonia 5 | 133
Polycystic Ovary Syndrome 5 | 332
3-methylglutaconic aciduria 4 | 29
Amyotrophic Lateral Sclerosis 4 | 431
Epilepsy 4 | 346
Liver carcinoma 4 | 217
Malaria 4 | 140
Vascular disease 4 | 281
active Crohn's disease 4 | 918
adrenocortical carcinoma 4 | 1,427
cutaneous lupus erythematosus 4 | 1,056
esophageal adenocarcinoma 4 | 737
juvenile dermatomyositis 4 | 1,189
posterior fossa group A ependymoma 4 | 1,511
primary pancreatic ductal adenocarcinoma 4 | 1,271
sonic hedgehog group medulloblastoma 4 | 1,482
spina bifida 4 | 1,064

Tissue

Cardiovascular System 142 | 17,958
Endocrine System 142 | 18,512
Female tissues 142 | 18,647
Liver and Pancreas 142 | 18,136
Nervous System 142 | 18,561
Urinary Tract 142 | 18,444
Blood and immune system 141 | 17,995
Digestive Tract 141 | 18,473
Male tissues 141 | 17,969
Respiratory system 141 | 17,484
Skin and soft tissues 141 | 18,115

Target Family

Enzyme 96 | 4,146
Non-IDG 30 | 11,971
Transporter 7 | 473
Kinase 5 | 634
GPCR 4 | 406

KEGG Pathway

Parkinson's disease 142 | 142
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.00384 11.8 165
Cytochrome c oxidase subunit 7C, mitochondrial COX7C Tdark Enzyme -0.99133 9.67 34
Cytochrome b MT-CYB Tbio Non-IDG -3.74473 5676.0 122
Alpha-synuclein SNCA Tchem Non-IDG -3.59982 3997.3 1484