Development Level

Tbio 68 | 11,445
Tclin 52 | 613
Tchem 13 | 1,598
Tdark 9 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to o... 5 | 239
abnormal embryo size 4 | 220
pallor 4 | 34
cataract 3 | 92
decreased bone mineral content 3 | 151
embryonic lethality prior to t... 3 | 278
increased circulating alkaline... 3 | 122
increased heart weight 3 | 62
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal lens morphology 2 | 81
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased circulating chloride... 2 | 30
decreased lean body mass 2 | 135
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased circulating calcium ... 2 | 34
increased circulating sodium l... 2 | 71
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal embryonic autopod pla... 1 | 2
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pelvic girdle bone mo... 1 | 12
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 5
abnormal seminal vesicle morph... 1 | 114
abnormal spine curvature 1 | 9
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased lactate dehydrogenas... 1 | 16
decreased mean platelet volume 1 | 25
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
hemorrhage 1 | 23
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
pale liver 1 | 6
pale yolk sac 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small liver 1 | 8
small spleen 1 | 19
thrombocytopenia 1 | 56

Disease

ovarian cancer 81 | 8,520
Multiple myeloma 53 | 1,332
Carcinoma 46 | 11,493
Diabetes mellitus type 2 46 | 69
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
osteosarcoma 45 | 7,950
lung cancer 39 | 4,740
psoriasis 39 | 6,694
Cerebellar Ataxia 32 | 304
Autosomal recessive predisposition 31 | 1,442
Leigh disease 31 | 100
glioblastoma 31 | 5,792
medulloblastoma, large-cell 30 | 6,241
Mitochondrial complex I deficiency 29 | 46
Blepharoptosis 28 | 231
Acidosis, Lactic 27 | 97
Lactic acidemia 27 | 95
atypical teratoid / rhabdoid tumor 27 | 5,112
Dystonia 26 | 164
Epilepsy 26 | 792
Parkinson's disease 25 | 392
astrocytic glioma 25 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
Cognitive delay 24 | 608
Global developmental delay 24 | 608
Mental and motor retardation 24 | 608
Seizures 24 | 596
ependymoma 24 | 4,679
Breast cancer 23 | 3,578
Sensorineural Hearing Loss (disorder) 23 | 284
diabetes mellitus 23 | 1,728
Dystonic disease 22 | 106
Nystagmus 21 | 317
Optic Atrophy 21 | 242
Muscle Weakness 20 | 170
Muscle hypotonia 20 | 571
Waldenstrons macroglobulinemia 20 | 765
group 3 medulloblastoma 20 | 4,104
oligodendroglioma 20 | 2,850
Developmental regression 19 | 95
Hyperreflexia 19 | 209
Increased serum lactate 19 | 60
Loss of developmental milestones 19 | 95
Mental deterioration in childhood 19 | 95
Mitochondrial Complex 1 Deficiency 19 | 28
Neurodevelopmental regression 19 | 95
Psychomotor regression 19 | 95
Psychomotor regression beginning in infancy 19 | 95
Psychomotor regression in infants 19 | 95
Psychomotor regression, progressive 19 | 95
Schizophrenia 19 | 1,160
adult high grade glioma 19 | 3,801
Depressive disorder 18 | 409
Failure to gain weight 18 | 365
Pediatric failure to thrive 18 | 365
Leigh syndrome 17 | 28
Strabismus 17 | 270
Abnormal mitochondria in muscle tissue 16 | 20
CSF lactate increased 16 | 33
Highly variable clinical phenotype 16 | 150
Highly variable phenotype and severity 16 | 150
Highly variable phenotype, even within families 16 | 150
Muscle Spasticity 16 | 195
NADH:Q(1) Oxidoreductase deficiency 16 | 24
Phenotypic variability 16 | 150
Alzheimer's disease 15 | 658
Hypertrophic Cardiomyopathy 15 | 117
Intellectual disability 15 | 1,016
Ophthalmoplegia 15 | 106
Respiratory Failure 15 | 104
breast carcinoma 15 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Astrocytoma, Pilocytic 14 | 3,081
Cancer 14 | 2,499
Dementia 14 | 175
Impaired exercise tolerance 14 | 42
Myopathy 14 | 185
Attention deficit hyperactivity disorder 13 | 278
Babinski Reflex 13 | 100
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Mitochondrial myopathy 13 | 26
Neurodegenerative disease 13 | 414
Poor school performance 13 | 645
astrocytoma 13 | 1,146
Bipolar Disorder 12 | 666
Fatigue 12 | 182
Hypoglycemia 12 | 152
Neurogenic Muscular Atrophy 12 | 139
Neurogenic muscle atrophy, especially in the lower limbs 12 | 139
Pick disease 12 | 1,894
Progressive disorder 12 | 142
Retinitis Pigmentosa 12 | 226
Skeletal muscle atrophy 12 | 139
muscle degeneration 12 | 139
non primary Sjogren syndrome sicca 12 | 891
primitive neuroectodermal tumor 12 | 3,035
ulcerative colitis 12 | 1,819

Tissue

Endocrine System 142 | 18,159
Female tissues 140 | 17,400
Male tissues 139 | 17,142
Skin and soft tissues 139 | 17,230
Digestive Tract 138 | 17,369
Blood and immune system 137 | 16,909
Liver and Pancreas 137 | 16,750
Nervous System 137 | 16,725
Urinary Tract 136 | 16,678
Cardiovascular System 135 | 15,192
Respiratory system 134 | 16,393

Target Family

Enzyme 96 | 4,145
Non-IDG 30 | 12,091
Transporter 7 | 473
Kinase 5 | 634
GPCR 4 | 408

KEGG Pathway

Parkinson's disease 142 | 142
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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