Development Level

Tbio 65 | 11,445
Tchem 54 | 1,598
Tclin 25 | 613
Tdark 10 | 6,588

Collection

Ion Channel: IDG Consortium (T... 15 | 99
Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
increased startle reflex 7 | 112
preweaning lethality, incomple... 7 | 499
abnormal behavior 5 | 298
abnormal bone structure 4 | 187
increased heart weight 4 | 62
abnormal spleen morphology 3 | 55
decreased bone mineral content 3 | 151
decreased fasted circulating g... 3 | 65
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
enlarged spleen 3 | 41
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
increased bone mineral content 3 | 108
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating magnesiu... 2 | 13
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased mean platelet volume 2 | 25
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged epididymis 2 | 31
enlarged heart 2 | 210
increased circulating sodium l... 2 | 71
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
male infertility 2 | 123
prenatal lethality 2 | 28
prolonged PR interval 2 | 15
abnormal coat appearance 1 | 31
abnormal facial morphology 1 | 17
abnormal femur morphology 1 | 14
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
abnormal vocalization 1 | 21
anophthalmia 1 | 33
cyanosis 1 | 7
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
enlarged heart atrium 1 | 4
enlarged thymus 1 | 5
hemorrhage 1 | 23
hydrometra 1 | 53
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased glycosylated hemoglo... 1 | 1
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
respiratory system phenotype 1 | 2
short tibia 1 | 97
small epididymis 1 | 3
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 122 | 11,493
ovarian cancer 85 | 8,520
medulloblastoma, large-cell 84 | 6,241
glioblastoma 81 | 5,792
osteosarcoma 77 | 7,950
atypical teratoid / rhabdoid tumor 75 | 5,112
ependymoma 69 | 4,679
psoriasis 69 | 6,694
adult high grade glioma 64 | 3,801
primitive neuroectodermal tumor 59 | 3,035
lung cancer 55 | 4,740
Astrocytoma, Pilocytic 52 | 3,081
Kidney cancer 52 | 2,613
Breast cancer 51 | 3,578
group 3 medulloblastoma 50 | 4,104
oligodendroglioma 49 | 2,850
astrocytic glioma 45 | 2,597
subependymal giant cell astrocytoma 41 | 2,287
Cancer 38 | 2,499
Pick disease 38 | 1,894
lung carcinoma 38 | 2,843
malignant mesothelioma 37 | 3,232
Schizophrenia 34 | 1,160
lung adenocarcinoma 32 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
pancreatic cancer 30 | 2,398
group 4 medulloblastoma 29 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
non-small cell lung cancer 29 | 2,890
invasive ductal carcinoma 28 | 2,951
colon cancer 27 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
pituitary cancer 26 | 1,972
ulcerative colitis 25 | 1,819
interstitial cystitis 23 | 2,312
Hypertension 22 | 396
diabetes mellitus 22 | 1,728
Epilepsy 21 | 792
Rheumatoid arthritis 21 | 1,191
Bipolar Disorder 20 | 666
Melanoma 20 | 711
tuberculosis 20 | 2,010
Depressive disorder 19 | 409
astrocytoma 19 | 1,146
breast carcinoma 19 | 1,638
Heart disease 18 | 306
Hypertensive disease 17 | 292
Intellectual disability 17 | 1,016
Liver cancer 17 | 604
Stomach Neoplasms 17 | 300
Autosomal recessive predisposition 16 | 1,442
Breast Neoplasms 16 | 445
cystic fibrosis 16 | 1,696
Mammary Neoplasms 15 | 425
Obesity 15 | 678
ductal carcinoma in situ 15 | 1,745
Major Depressive Disorder 14 | 301
Mental Depression 14 | 333
Multiple myeloma 14 | 1,332
Waldenstrons macroglobulinemia 14 | 765
acute quadriplegic myopathy 14 | 1,158
Alzheimer's disease 13 | 658
Kidney disease 13 | 430
Lung Neoplasms 13 | 232
Skin cancer 13 | 469
Unipolar Depression 13 | 250
dermatomyositis 13 | 966
juvenile dermatomyositis 13 | 1,187
Adenoma 12 | 167
Endometrial cancer 12 | 311
Seizures 12 | 596
medulloblastoma 12 | 720
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
primary pancreatic ductal adenocarcinoma 12 | 1,109
Colonic Neoplasms 11 | 142
Dull intelligence 11 | 645
Liver Cirrhosis, Experimental 11 | 769
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Muscle hypotonia 11 | 571
Poor school performance 11 | 645
Renal Cell Carcinoma 11 | 214
Substance Withdrawal Syndrome 11 | 55
adrenocortical carcinoma 11 | 1,428
Acquired scoliosis 10 | 281
Autistic Disorder 10 | 364
Cardiomegaly 10 | 116
Cognitive delay 10 | 608
Curvature of spine 10 | 282
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Neoplasm Invasiveness 10 | 161
Parkinson's disease 10 | 392
Prostatic Neoplasms 10 | 495
Short stature 10 | 531
Vascular disease 10 | 319
aldosterone-producing adenoma 10 | 665
nasopharyngeal carcinoma 10 | 1,058
pancreatic carcinoma 10 | 562

Tissue

Endocrine System 151 | 18,159
Digestive Tract 146 | 17,369
Nervous System 145 | 16,725
Male tissues 144 | 17,142
Blood and immune system 143 | 16,909
Female tissues 143 | 17,400
Skin and soft tissues 143 | 17,230
Liver and Pancreas 138 | 16,750
Respiratory system 137 | 16,393
Urinary Tract 135 | 16,678
Cardiovascular System 129 | 15,192

Target Family

Enzyme 44 | 4,145
Kinase 38 | 634
Ion Channel 35 | 344
Non-IDG 28 | 12,091
Transcription Factor 8 | 1,400
GPCR 1 | 408

KEGG Pathway

Oxytocin signaling pathway 154 | 154
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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