Development Level

Tbio 69 | 11,445
Tchem 39 | 1,598
Tclin 18 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased body weight 4 | 161
increased lean body mass 4 | 172
abnormal behavior 3 | 298
abnormal lens morphology 3 | 81
decreased circulating amylase ... 3 | 28
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating triglyce... 3 | 79
embryonic lethality prior to t... 3 | 278
increased bone mineral content 3 | 108
increased erythrocyte cell num... 3 | 39
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased bone mineral density 2 | 126
enlarged heart 2 | 210
impaired righting response 2 | 26
increased circulating alkaline... 2 | 122
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased neutrophil cell numb... 2 | 46
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal glucose homeostasis 1 | 4
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased basophil cell number 1 | 7
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
short tibia 1 | 97
small superior vagus ganglion 1 | 74
stereotypic behavior 1 | 3
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

Carcinoma 87 | 11,493
Cancer 85 | 2,499
osteosarcoma 73 | 7,950
ovarian cancer 69 | 8,520
psoriasis 67 | 6,694
lung cancer 61 | 4,740
glioblastoma 60 | 5,792
medulloblastoma, large-cell 52 | 6,241
lung carcinoma 47 | 2,843
tuberculosis 38 | 2,010
Arthritis 36 | 290
Astrocytoma, Pilocytic 36 | 3,081
non-small cell lung cancer 36 | 2,890
ulcerative colitis 36 | 1,819
atypical teratoid / rhabdoid tumor 35 | 5,112
Rheumatoid arthritis 34 | 1,191
interstitial cystitis 34 | 2,312
malignant mesothelioma 34 | 3,232
adult high grade glioma 33 | 3,801
ependymoma 33 | 4,679
invasive ductal carcinoma 33 | 2,951
pancreatic cancer 33 | 2,398
Schizophrenia 32 | 1,160
Breast cancer 28 | 3,578
diabetes mellitus 28 | 1,728
subependymal giant cell astrocytoma 28 | 2,287
group 4 medulloblastoma 25 | 1,855
lung adenocarcinoma 25 | 2,716
Autosomal recessive predisposition 24 | 1,442
cutaneous lupus erythematosus 24 | 1,057
cystic fibrosis 24 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
Kidney cancer 23 | 2,613
group 3 medulloblastoma 21 | 4,104
juvenile dermatomyositis 21 | 1,187
Liver Cirrhosis, Experimental 20 | 769
Multiple Sclerosis 20 | 540
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
oligodendroglioma 20 | 2,850
Kidney disease 19 | 430
pituitary cancer 19 | 1,972
Asthma 18 | 385
Lung Neoplasms 18 | 232
Osteoporosis 18 | 363
primitive neuroectodermal tumor 18 | 3,035
Depressive disorder 17 | 409
periodontitis 17 | 293
Alzheimer's disease 16 | 658
Atherosclerosis 16 | 291
Inflammatory bowel disease 16 | 151
Lung disease 16 | 142
Vascular disease 16 | 319
dermatomyositis 16 | 966
Breast Neoplasms 15 | 445
Mammary Neoplasms 15 | 425
Osteopetrosis 15 | 43
adrenocortical carcinoma 15 | 1,428
astrocytoma 15 | 1,146
colon cancer 15 | 1,478
mucosa-associated lymphoid tissue lymphoma 15 | 484
pancreatic carcinoma 15 | 562
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
primary Sjogren syndrome 15 | 735
Coronary artery disease 14 | 268
Epilepsy 14 | 792
Hypersensitivity reaction type II disease 14 | 253
Immunologic Deficiency Syndromes 14 | 113
Pick disease 14 | 1,894
Recurrent respiratory infections 14 | 141
acute myeloid leukemia 14 | 783
ductal carcinoma in situ 14 | 1,745
Hypertensive disease 13 | 292
Liver disease 13 | 237
Multiple myeloma 13 | 1,332
Obesity 13 | 678
Seizures 13 | 596
breast carcinoma 13 | 1,638
primary pancreatic ductal adenocarcinoma 13 | 1,109
Brain Ischemia 12 | 110
Diarrhea 12 | 253
Hyperglycemia 12 | 137
Mental Depression 12 | 333
Parkinson's disease 12 | 392
Waldenstrons macroglobulinemia 12 | 765
astrocytic glioma 12 | 2,597
hepatocellular carcinoma 12 | 547
Bipolar Disorder 11 | 666
Carcinoma, Hepatocellular 11 | 228
Cholestasis, Extrahepatic 11 | 25
Fever 11 | 138
Hypertension 11 | 396
Liver carcinoma 11 | 240
Neoplasm Metastasis 11 | 168
Pneumonia 11 | 174
acute quadriplegic myopathy 11 | 1,158
nasopharyngeal carcinoma 11 | 1,058
Arthritis, Rheumatoid 10 | 174
Atopic dermatitis 10 | 952
Curvature of spine 10 | 282

Tissue

Blood and immune system 122 | 16,909
Digestive Tract 122 | 17,369
Endocrine System 122 | 18,159
Liver and Pancreas 122 | 16,750
Female tissues 121 | 17,400
Respiratory system 121 | 16,393
Skin and soft tissues 121 | 17,230
Urinary Tract 121 | 16,678
Male tissues 120 | 17,142
Nervous System 118 | 16,725
Cardiovascular System 113 | 15,192

Target Family

Non-IDG 56 | 12,091
Kinase 36 | 634
Transcription Factor 19 | 1,400
Enzyme 14 | 4,145
GPCR 1 | 408
Nuclear Receptor 1 | 48

KEGG Pathway

Osteoclast differentiation 127 | 127
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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