Development Level

Tbio 59 | 11,178
Tchem 43 | 1,885
Tdark 12 | 6,569
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 12 | 979
abnormal bone structure 6 | 187
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
male infertility 5 | 123
increased mean corpuscular vol... 4 | 92
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
decreased bone mineral content 3 | 151
embryonic growth retardation 3 | 106
decreased bone mineral density 2 | 126
decreased mean corpuscular hem... 2 | 50
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
female infertility 2 | 60
increased hematocrit 2 | 46
short tibia 2 | 97
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
brachydactyly 1 | 19
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
edema 1 | 59
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
sclerocornea 1 | 2
shortened RR interval 1 | 17
small epididymis 1 | 3
small kidney 1 | 16
small spleen 1 | 19
small testis 1 | 58
syndactyly 1 | 23
urinary bladder obstruction 1 | 4

Disease

Carcinoma 78 | 11,192
ovarian cancer 69 | 8,297
medulloblastoma, large-cell 66 | 6,086
glioblastoma 60 | 5,635
atypical teratoid / rhabdoid tumor 57 | 4,971
psoriasis 54 | 6,514
osteosarcoma 53 | 7,766
adult high grade glioma 46 | 3,701
Breast cancer 44 | 3,469
group 3 medulloblastoma 42 | 4,002
Cancer 41 | 2,388
ependymoma 40 | 4,559
primitive neuroectodermal tumor 40 | 2,957
lung cancer 37 | 4,607
astrocytic glioma 35 | 2,530
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,204
lung adenocarcinoma 32 | 2,627
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,902
malignant mesothelioma 30 | 3,135
Astrocytoma, Pilocytic 28 | 3,006
oligodendroglioma 28 | 2,768
non-small cell lung cancer 26 | 2,799
Kidney cancer 25 | 2,548
invasive ductal carcinoma 25 | 2,867
colon cancer 21 | 1,428
Pick disease 20 | 1,856
adrenocortical carcinoma 20 | 1,385
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,872
pancreatic cancer 19 | 2,322
subependymal giant cell astrocytoma 19 | 2,230
breast carcinoma 18 | 1,589
ductal carcinoma in situ 16 | 1,686
Atopic dermatitis 15 | 915
Endometriosis 15 | 521
group 4 medulloblastoma 15 | 1,806
interstitial cystitis 15 | 2,237
Schizophrenia 14 | 1,136
Waldenstrons macroglobulinemia 14 | 742
lung carcinoma 14 | 2,755
Bipolar Disorder 13 | 646
diabetes mellitus 13 | 1,683
Dull intelligence 12 | 634
Intellectual disability 12 | 998
Low intelligence 12 | 634
Mental Retardation 12 | 634
Mental deficiency 12 | 634
Multiple myeloma 12 | 1,296
Poor school performance 12 | 634
ulcerative colitis 12 | 1,765
Cognitive delay 11 | 596
Global developmental delay 11 | 596
Mental and motor retardation 11 | 596
dermatomyositis 11 | 941
nasopharyngeal carcinoma 11 | 1,024
pituitary cancer 11 | 1,915
Autosomal recessive predisposition 10 | 1,407
Epilepsy 10 | 775
Short stature 10 | 514
acute quadriplegic myopathy 10 | 1,133
juvenile dermatomyositis 10 | 1,147
medulloblastoma 10 | 702
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,911
Alzheimer's disease 9 | 640
Depressive disorder 9 | 401
Prostatic Neoplasms 9 | 472
Rheumatoid arthritis 9 | 1,156
esophageal adenocarcinoma 9 | 696
Acquired metabolic disease 8 | 329
Melanoma 8 | 689
Mental Depression 8 | 325
Obesity 8 | 655
Small head 8 | 366
primary Sjogren syndrome 8 | 710
primary pancreatic ductal adenocarcinoma 8 | 1,071
spina bifida 8 | 1,053
tuberculosis 8 | 1,963
Amyotrophic lateral sclerosis 7 | 437
Anteverted nostril 7 | 186
Hypertension 7 | 372
Liver Cirrhosis, Experimental 7 | 733
Muscle hypotonia 7 | 562
Polycystic ovary syndrome 7 | 348
cutaneous lupus erythematosus 7 | 1,016
pediatric high grade glioma 7 | 1,035
Breast Neoplasms 6 | 423
Downward slant of palpebral fissure 6 | 158
Fetal Growth Retardation 6 | 186
Heart disease 6 | 288
Infant, Small for Gestational Age 6 | 174
Infertility 6 | 176
Intrauterine retardation 6 | 174
Liver cancer 6 | 589
Mammary Neoplasms 6 | 403
Osteoporosis 6 | 348
Seizures 6 | 584
active Crohn's disease 6 | 882
astrocytoma 6 | 1,113
cystic fibrosis 6 | 1,629
posterior fossa group A ependymoma 6 | 456
progressive supranuclear palsy 6 | 656

Tissue

Endocrine System 119 | 18,159
Digestive Tract 116 | 17,369
Blood and immune system 115 | 16,909
Female tissues 115 | 17,400
Male tissues 115 | 17,142
Skin and soft tissues 115 | 17,230
Liver and Pancreas 114 | 16,750
Nervous System 110 | 16,725
Respiratory system 110 | 16,393
Urinary Tract 109 | 16,678
Cardiovascular System 105 | 15,192

Target Family

Non-IDG 54 | 12,091
Enzyme 38 | 4,145
Kinase 24 | 634
Ion Channel 3 | 344
Nuclear Receptor 2 | 48

KEGG Pathway

Oocyte meiosis 121 | 121
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 3 ADCY3 Tbio Enzyme -2.31593 204.4 82
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform PPP2R5B Tbio Enzyme -0.59131 2.64 81
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform PPP2R5A Tchem Enzyme -0.54568 3.09 202
Putative speedy protein E16 SPDYE16 Tdark Non-IDG 0.00000 0
Ribosomal protein S6 kinase alpha-2 RPS6KA2 Tchem Kinase -2.17609 136.7 406
Calmodulin-like protein 4 CALML4 Tdark Non-IDG 0.19 0.59 96
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1 Tchem Ion Channel -2.75840 565.6 230
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform PPP2R5C Tbio Enzyme -0.93513 9.09 186
Progesterone receptor PGR Tclin Nuclear Receptor -3.94412 7951.2 2098