Development Level

Tbio 13 | 11,445
Tclin 3 | 613
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
cataract 2 | 92
embryonic lethality prior to t... 2 | 278
abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
decreased circulating chloride... 1 | 30
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
enlarged heart 1 | 210
increased or absent threshold ... 1 | 101
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 14 | 11,493
ovarian cancer 12 | 8,520
osteosarcoma 11 | 7,950
psoriasis 10 | 6,694
glioblastoma 9 | 5,792
medulloblastoma, large-cell 9 | 6,241
non-small cell lung cancer 9 | 2,890
Breast cancer 7 | 3,578
Cancer 7 | 2,499
atypical teratoid / rhabdoid tumor 7 | 5,112
lung cancer 7 | 4,740
pancreatic cancer 7 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Adverse reaction to drug 6 | 61
Autosomal recessive predisposition 6 | 1,442
Drug-Related Side Effects and Adverse Reactions 6 | 62
adrenocortical carcinoma 6 | 1,428
adult high grade glioma 6 | 3,801
group 3 medulloblastoma 6 | 4,104
Breast Neoplasms 5 | 445
Cleft Lip 5 | 141
Cleft Palate 5 | 271
Mammary Neoplasms 5 | 425
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
nasopharyngeal carcinoma 5 | 1,058
primitive neuroectodermal tumor 5 | 3,035
Arthritis, Rheumatoid 4 | 174
Astrocytoma, Pilocytic 4 | 3,081
Down syndrome 4 | 499
Epilepsy 4 | 792
Kidney cancer 4 | 2,613
Muscle hypotonia 4 | 571
Nervous System Diseases 4 | 53
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Seizures 4 | 596
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
ependymoma 4 | 4,679
nervous system disorder 4 | 53
oligodendroglioma 4 | 2,850
tuberculosis 4 | 2,010
Adenocarcinoma of lung 3 | 142
Anemia 3 | 365
Anemia, Megaloblastic 3 | 16
Bipolar Disorder 3 | 666
Cognitive delay 3 | 608
Colorectal Neoplasms 3 | 243
Disease Models, Animal 3 | 155
Dull intelligence 3 | 645
Global developmental delay 3 | 608
Homocystinuria 3 | 21
Hyperhomocysteinemia 3 | 37
Intellectual disability 3 | 1,016
Liver Cirrhosis, Experimental 3 | 769
Low intelligence 3 | 645
Lymphoma, Follicular 3 | 18
Lymphoma, Non-Hodgkin 3 | 24
Malignant mesothelioma of pleura 3 | 7
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Neural tube defect, folate-sensitive 3 | 4
Poor school performance 3 | 645
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
malignant mesothelioma 3 | 3,232
nephrosclerosis 3 | 333
neural tube defect 3 | 9
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074
Alzheimer's disease 2 | 658
Atopic dermatitis 2 | 952
Depressive disorder 2 | 409
Endometriosis 2 | 540
Infertility, Male 2 | 46
Malaria 2 | 160
Male infertility 2 | 206
Mental Depression 2 | 333
Methylmalonic acidemia 2 | 37
Polycystic ovary syndrome 2 | 360
Prostatic Neoplasms 2 | 495
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
cystic fibrosis 2 | 1,696
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 19 | 16,909
Cardiovascular System 19 | 15,192
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Liver and Pancreas 19 | 16,750
Male tissues 19 | 17,142
Nervous System 19 | 16,725
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678
Respiratory system 18 | 16,393

Target Family

Enzyme 17 | 4,145
Non-IDG 2 | 12,091

KEGG Pathway

One carbon pool by folate 19 | 19
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.23276 170.0 418
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.93014 835.0 246
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Dihydrofolate reductase DHFR Tclin Enzyme -2.99192 972.8 202
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Trifunctional purine biosynthetic protein adenosine-3 GART Tclin Non-IDG -2.26480 181.2 139
Aminomethyltransferase, mitochondrial AMT Tbio Enzyme -2.19912 157.9 94
Methionyl-tRNA formyltransferase, mitochondrial MTFMT Tbio Enzyme -2.42792 264.8 69