Development Level

Tbio 37 | 11,445
Tchem 5 | 1,598
Tclin 2 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
embryonic growth retardation 1 | 106
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 30 | 8,520
Carcinoma 26 | 11,493
Cockayne syndrome 23 | 60
osteosarcoma 22 | 7,950
Xeroderma pigmentosum 19 | 43
lung cancer 19 | 4,740
group 3 medulloblastoma 17 | 4,104
malignant mesothelioma 16 | 3,232
Cancer 14 | 2,499
Photosensitive trichothiodystrophy 14 | 30
psoriasis 14 | 6,694
Autosomal recessive predisposition 12 | 1,442
Hypogonadism 12 | 173
Sensorineural Hearing Loss (disorder) 12 | 284
medulloblastoma, large-cell 12 | 6,241
Cataract 11 | 297
Cryptorchidism 11 | 296
Photosensitivity of skin 11 | 51
Intellectual disability 10 | 1,016
Lens Opacities 10 | 231
Short stature 10 | 531
Strabismus 10 | 270
atypical teratoid / rhabdoid tumor 10 | 5,112
glioblastoma 10 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Atrophic condition of skin 9 | 25
Dry skin 9 | 75
Dull intelligence 9 | 645
Freckles 9 | 33
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Optic Atrophy 9 | 242
Poor school performance 9 | 645
Small head 9 | 374
Xerosis 9 | 75
ependymoma 9 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
primitive neuroectodermal tumor 9 | 3,035
Arthralgia 8 | 90
Breast cancer 8 | 3,578
Cerebellar Ataxia 8 | 304
Conjunctival telangiectasis 8 | 14
Electroencephalogram abnormal 8 | 101
Failure to gain weight 8 | 365
Keratitis 8 | 62
Melanoma 8 | 711
Pediatric failure to thrive 8 | 365
Poikiloderma 8 | 14
Xeroderma pigmentosum group B 8 | 20
non-small cell lung cancer 8 | 2,890
Basal cell carcinoma 7 | 54
Defective DNA repair after ultraviolet radiation damage 7 | 7
Dental abnormalities 7 | 60
Developmental regression 7 | 95
Erythema 7 | 58
Fatigue 7 | 182
Fever 7 | 138
Flushing 7 | 60
Hyperkeratosis 7 | 50
Hyperpigmented macules 7 | 42
Impaired cognition 7 | 96
Kidney cancer 7 | 2,613
Loss of developmental milestones 7 | 95
Mental deterioration in childhood 7 | 95
Mental impairment 7 | 95
Muscle Spasticity 7 | 195
Neurodevelopmental regression 7 | 95
Papilloma 7 | 44
Progressive mental retardation 7 | 37
Psychomotor regression 7 | 95
Psychomotor regression beginning in infancy 7 | 95
Psychomotor regression in infants 7 | 95
Psychomotor regression, progressive 7 | 95
Telangiectasia of the skin 7 | 39
Thin skin 7 | 47
Tooth Abnormalities 7 | 69
Xeroderma pigmentosum group D 7 | 33
hypopigmented skin patch 7 | 59
nasopharyngeal carcinoma 7 | 1,058
Basal cell nevi 6 | 23
Epilepsy 6 | 792
Hypoplastic mandible condyle 6 | 275
Low Vision 6 | 174
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Muscle hypotonia 6 | 571
Photodysphoria 6 | 121
Photophobia 6 | 121
Seizures 6 | 596
Spider Veins 6 | 17
Squamous cell carcinoma of skin 6 | 11
Telangiectasis 6 | 36
Visual Impairment 6 | 174
Waldenstrons macroglobulinemia 6 | 765
Xeroderma pigmentosum group G 6 | 16
diabetes mellitus 6 | 1,728
oligodendroglioma 6 | 2,850
Decreased size of eyeball 5 | 97
Mental and motor retardation 5 | 608

Tissue

Blood and immune system 45 | 16,909
Cardiovascular System 45 | 15,192
Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Male tissues 45 | 17,142
Nervous System 45 | 16,725
Respiratory system 45 | 16,393
Skin and soft tissues 45 | 17,230
Urinary Tract 45 | 16,678

Target Family

Non-IDG 30 | 12,091
Enzyme 15 | 4,145
Kinase 1 | 634

KEGG Pathway

Nucleotide excision repair 46 | 46
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
DNA repair protein complementing XP-G cells ERCC5 Tchem Enzyme -2.06679 113.9 255
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
Chimeric ERCC6-PGBD3 protein ERCC6 Tbio Non-IDG -2.31776 361.5 0
DNA excision repair protein ERCC-6 ERCC6 Tbio Non-IDG -2.31776 361.5 163
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.30866 19.7 176
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
DNA damage-binding protein 1 DDB1 Tbio Non-IDG -2.34719 202.5 353