Development Level

Tbio 10 | 11,445
Tchem 3 | 1,598

IMPC Phenotype

decreased body length 1 | 101
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
preweaning lethality, incomple... 1 | 499

Disease

Cancer 10 | 2,499
Carcinoma 10 | 11,493
osteosarcoma 10 | 7,950
Severe combined immunodeficiency 7 | 51
lung cancer 7 | 4,740
ovarian cancer 6 | 8,520
DNA ligase IV deficiency 5 | 7
Microcephaly 5 | 166
Nijmegen breakage syndrome 5 | 24
Werner syndrome 5 | 29
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
medulloblastoma, large-cell 5 | 6,241
psoriasis 5 | 6,694
Ataxia telangiectasia 4 | 34
Kidney cancer 4 | 2,613
Small head 4 | 374
atypical teratoid / rhabdoid tumor 4 | 5,112
colon cancer 4 | 1,478
glioblastoma 4 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
Autosomal recessive predisposition 3 | 1,442
Dull intelligence 3 | 645
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Poor school performance 3 | 645
Short stature 3 | 531
Waldenstrons macroglobulinemia 3 | 765
Xeroderma pigmentosum 3 | 43
ependymoma 3 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
Acute blood cancer 2 | 6
Acute leukemia 2 | 15
Adenocarcinoma of lung 2 | 142
Biparietal narrowing 2 | 28
Bird-like facies 2 | 4
Brachycephaly 2 | 88
Breast cancer 2 | 3,578
Broad cranium shape 2 | 88
Broad flat nasal bridge 2 | 236
Chromosome Breakage 2 | 36
Cognitive delay 2 | 608
Congenital Epicanthus 2 | 177
Cryptorchidism 2 | 296
Decreased width of the skull 2 | 28
Disease Models, Animal 2 | 155
Dysarthria 2 | 192
Dysdiadochokinesis 2 | 25
Erythema 2 | 58
Fetal Growth Retardation 2 | 189
Flushing 2 | 60
Global developmental delay 2 | 608
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hereditary Breast and Ovarian Cancer Syndrome 2 | 14
Hypoplastic mandible condyle 2 | 275
Increased chromosomal breakage 2 | 27
Infant, Small for Gestational Age 2 | 176
Intrauterine retardation 2 | 176
LIG4 Syndrome 2 | 2
Large beaked nose 2 | 5
Low anterior hairline 2 | 30
Lymphoma 2 | 81
Mandibular hypoplasia 2 | 275
Mental and motor retardation 2 | 608
Micrognathism 2 | 275
Multiple myeloma 2 | 1,332
Nasal bridge wide 2 | 236
Omenn syndrome 2 | 13
Pancytopenia 2 | 45
Photosensitivity of skin 2 | 51
Pick disease 2 | 1,894
Poor growth 2 | 114
Sloping forehead 2 | 46
Systemic lupus erythematosus 2 | 194
Telecanthus 2 | 62
Thin lips 2 | 49
Upward slant of palpebral fissure 2 | 75
Very poor growth 2 | 114
Wide skull shape 2 | 88
acute quadriplegic myopathy 2 | 1,158
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
diabetes mellitus 2 | 1,728
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
primitive neuroectodermal tumor 2 | 3,035
progressive supranuclear palsy 2 | 676
Congenital hypoplasia of kidney 1 | 32
Convex nasal bridge 1 | 57
Gaucher disease type 3 1 | 67
Hypertriglyceridemia result 1 | 37
Isolated growth hormone deficiency 1 | 30
Prominent nasal bridge 1 | 57

Tissue

Blood and immune system 13 | 16,909
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Cardiovascular System 12 | 15,192
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 5 | 4,145
Kinase 1 | 634

KEGG Pathway

Non-homologous end-joining 13 | 13
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA ligase 4 LIG4 Tbio Enzyme -2.14909 140.9 204
Non-homologous end-joining factor 1 NHEJ1 Tbio Non-IDG -1.93558 91.5 270
DNA repair protein XRCC4 XRCC4 Tbio Non-IDG -2.38352 232.9 322
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.68622 470.8 874
DNA-dependent protein kinase catalytic subunit PRKDC Tchem Kinase -2.85973 723.4 1160
Protein artemis DCLRE1C Tbio Non-IDG -2.27419 184.9 252
Double-strand break repair protein MRE11 MRE11 Tbio Non-IDG -2.02762 98.5 459
X-ray repair cross-complementing protein 6 XRCC6 Tbio Non-IDG -2.86424 688.3 865
DNA nucleotidylexotransferase DNTT Tchem Enzyme -3.41739 1725.2 436
Flap endonuclease 1 FEN1 Tchem Enzyme -2.79171 617.0 406