Development Level

Tbio 54 | 11,445
Tclin 51 | 613
Tchem 36 | 1,598
Tdark 8 | 6,588

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to o... 6 | 239
increased circulating alkaline... 6 | 122
abnormal embryo size 5 | 220
embryonic lethality prior to t... 5 | 278
abnormal behavior 4 | 298
cataract 4 | 92
decreased circulating choleste... 4 | 93
decreased lymphocyte cell numb... 4 | 83
decreased vertical activity 4 | 208
increased circulating phosphat... 4 | 26
pallor 4 | 34
preweaning lethality, incomple... 4 | 499
abnormal lens morphology 3 | 81
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating amylase ... 3 | 28
decreased circulating chloride... 3 | 30
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
enlarged spleen 3 | 41
increased circulating calcium ... 3 | 34
increased circulating choleste... 3 | 66
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
increased neutrophil cell numb... 3 | 46
increased red blood cell distr... 3 | 34
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal hindbrain development 2 | 16
abnormal kidney morphology 2 | 65
abnormal neural tube closure 2 | 46
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased spleen weight 2 | 10
embryonic growth retardation 2 | 106
enlarged kidney 2 | 14
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating bilirubi... 2 | 16
increased circulating glucose ... 2 | 24
increased circulating total pr... 2 | 28
increased eosinophil cell numb... 2 | 11
increased grip strength 2 | 41
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased large unstained cell... 2 | 5
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased spleen weight 2 | 10
limb grasping 2 | 41
tremors 2 | 39
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal neural tube morpholog... 1 | 12
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
increased circulating aspartat... 1 | 15
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
prenatal lethality 1 | 28
small testis 1 | 58
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

ovarian cancer 87 | 8,520
Carcinoma 63 | 11,493
psoriasis 59 | 6,694
Cancer 58 | 2,499
osteosarcoma 58 | 7,950
glioblastoma 51 | 5,792
lung cancer 49 | 4,740
medulloblastoma, large-cell 47 | 6,241
diabetes mellitus 46 | 1,728
Multiple myeloma 44 | 1,332
Diabetes mellitus type 2 40 | 69
atypical teratoid / rhabdoid tumor 40 | 5,112
Treatment Refractory Type 2 Diabetes Mellitus 39 | 53
ependymoma 38 | 4,679
Schizophrenia 35 | 1,160
Breast cancer 33 | 3,578
Obesity 33 | 678
Autosomal recessive predisposition 32 | 1,442
Seizures 28 | 596
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
Cognitive delay 27 | 608
Epilepsy 27 | 792
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
adult high grade glioma 27 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
Cerebellar Ataxia 26 | 304
malignant mesothelioma 26 | 3,232
invasive ductal carcinoma 24 | 2,951
Blepharoptosis 23 | 231
astrocytic glioma 23 | 2,597
Failure to gain weight 22 | 365
Hyperglycemia 22 | 137
Leigh disease 22 | 100
Mitochondrial complex I deficiency 22 | 46
Pediatric failure to thrive 22 | 365
Sensorineural Hearing Loss (disorder) 22 | 284
breast carcinoma 22 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
Acidosis, Lactic 21 | 97
Diabetes Mellitus, Non-Insulin-Dependent 21 | 145
Lactic acidemia 21 | 95
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
oligodendroglioma 21 | 2,850
tuberculosis 21 | 2,010
Astrocytoma, Pilocytic 20 | 3,081
Muscle hypotonia 20 | 571
Stomach Neoplasms 20 | 300
Arthritis 19 | 290
Bipolar Disorder 19 | 666
Depressive disorder 19 | 409
Diabetes Mellitus, Experimental 19 | 108
Intellectual disability 19 | 1,016
group 3 medulloblastoma 19 | 4,104
group 4 medulloblastoma 19 | 1,855
lung carcinoma 19 | 2,843
Alzheimer's disease 18 | 658
Dull intelligence 18 | 645
Fatty liver disease 18 | 103
Hyperreflexia 18 | 209
Hypertension 18 | 396
Hypoglycemia 18 | 152
Liver disease 18 | 237
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Muscle Weakness 18 | 170
Poor school performance 18 | 645
Rheumatoid arthritis 18 | 1,191
astrocytoma 18 | 1,146
pituitary cancer 18 | 1,972
Diabetes Mellitus, Type 2 17 | 142
Kidney disease 17 | 430
Nystagmus 17 | 317
Respiratory Failure 17 | 104
Strabismus 17 | 270
Vascular disease 17 | 319
Waldenstrons macroglobulinemia 17 | 765
primitive neuroectodermal tumor 17 | 3,035
ulcerative colitis 17 | 1,819
Brain Ischemia 16 | 110
Breast Neoplasms 16 | 445
CSF lactate increased 16 | 33
Carcinoma, Hepatocellular 16 | 228
Highly variable clinical phenotype 16 | 150
Highly variable phenotype and severity 16 | 150
Highly variable phenotype, even within families 16 | 150
Hypertensive disease 16 | 292
Hypertrophic Cardiomyopathy 16 | 117
Liver carcinoma 16 | 240
Mammary Neoplasms 16 | 425
Muscle Spasticity 16 | 195
Phenotypic variability 16 | 150
Polycystic ovary syndrome 16 | 360
subependymal giant cell astrocytoma 16 | 2,287
Atherosclerosis 15 | 291
Heart disease 15 | 306
Inflammatory bowel disease 15 | 151
Prostatic Neoplasms 15 | 495
cystic fibrosis 15 | 1,696

Tissue

Endocrine System 149 | 18,159
Skin and soft tissues 149 | 17,230
Digestive Tract 148 | 17,369
Female tissues 148 | 17,400
Blood and immune system 147 | 16,909
Liver and Pancreas 147 | 16,750
Male tissues 147 | 17,142
Nervous System 147 | 16,725
Urinary Tract 147 | 16,678
Cardiovascular System 145 | 15,192
Respiratory system 144 | 16,393

Target Family

Enzyme 76 | 4,145
Non-IDG 36 | 12,091
Kinase 23 | 634
Transcription Factor 11 | 1,400
Nuclear Receptor 3 | 48

KEGG Pathway

Non-alcoholic fatty liver dise... 149 | 149
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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