Development Level

Tchem 60 | 1,598
Tbio 42 | 11,445
Tclin 15 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 6 | 499
decreased body weight 4 | 161
abnormal bone structure 3 | 187
abnormal gait 3 | 69
abnormal retina morphology 3 | 71
decreased circulating creatini... 3 | 39
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
increased circulating alkaline... 3 | 122
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
abnormal digit morphology 2 | 10
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased prepulse inhibition 2 | 82
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased circulating glucose ... 2 | 24
increased erythrocyte cell num... 2 | 39
increased mean corpuscular hem... 2 | 96
short tibia 2 | 97
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal glucose homeostasis 1 | 4
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal rib morphology 1 | 10
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
absent spleen 1 | 3
cataract 1 | 92
cyanosis 1 | 7
decreased IgG3 level 1 | 1
decreased basophil cell number 1 | 16
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
enlarged urinary bladder 1 | 8
hemorrhage 1 | 23
hypoactivity 1 | 132
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating iron lev... 1 | 30
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 41
microphthalmia 1 | 26
prenatal lethality 1 | 28
respiratory system phenotype 1 | 2
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 93 | 11,493
ovarian cancer 73 | 8,520
Cancer 70 | 2,499
osteosarcoma 69 | 7,950
medulloblastoma, large-cell 59 | 6,241
glioblastoma 58 | 5,792
psoriasis 56 | 6,694
ependymoma 51 | 4,679
atypical teratoid / rhabdoid tumor 49 | 5,112
lung cancer 46 | 4,740
adult high grade glioma 38 | 3,801
Breast cancer 36 | 3,578
Schizophrenia 32 | 1,160
group 3 medulloblastoma 32 | 4,104
oligodendroglioma 30 | 2,850
Astrocytoma, Pilocytic 29 | 3,081
diabetes mellitus 29 | 1,728
group 4 medulloblastoma 27 | 1,855
primitive neuroectodermal tumor 27 | 3,035
astrocytic glioma 26 | 2,597
Kidney cancer 25 | 2,613
malignant mesothelioma 25 | 3,232
subependymal giant cell astrocytoma 25 | 2,287
Alzheimer's disease 21 | 658
Epilepsy 21 | 792
Intellectual disability 21 | 1,016
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
tuberculosis 20 | 2,010
Pick disease 19 | 1,894
Rheumatoid arthritis 19 | 1,191
Seizures 19 | 596
astrocytoma 19 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
juvenile dermatomyositis 19 | 1,187
pancreatic cancer 19 | 2,398
Breast Neoplasms 18 | 445
Vascular disease 18 | 319
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
lung carcinoma 18 | 2,843
Bipolar Disorder 17 | 666
Dull intelligence 17 | 645
Low intelligence 17 | 645
Mammary Neoplasms 17 | 425
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Poor school performance 17 | 645
Short stature 17 | 531
Toxic encephalopathy 17 | 141
invasive ductal carcinoma 17 | 2,951
non-small cell lung cancer 17 | 2,890
Depressive disorder 16 | 409
Multiple myeloma 16 | 1,332
Orbital separation excessive 16 | 244
Blepharoptosis 15 | 231
Byzanthine arch palate 15 | 194
Downward slant of palpebral fissure 15 | 158
Lung Neoplasms 15 | 232
Muscle hypotonia 15 | 571
cystic fibrosis 15 | 1,696
lung adenocarcinoma 15 | 2,716
pituitary cancer 15 | 1,972
ulcerative colitis 15 | 1,819
Acquired scoliosis 14 | 281
Cognitive delay 14 | 608
Curvature of spine 14 | 282
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Obesity 14 | 678
Prostatic Neoplasms 14 | 495
Splenomegaly 14 | 190
dermatomyositis 14 | 966
interstitial cystitis 14 | 2,312
High forehead 13 | 102
Hypoplastic mandible condyle 13 | 275
Mandibular hypoplasia 13 | 275
Mental Depression 13 | 333
Micrognathism 13 | 275
Tall forehead 13 | 102
breast carcinoma 13 | 1,638
Autosomal recessive predisposition 12 | 1,442
Concave bridge of nose 12 | 195
Cryptorchidism 12 | 296
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Frontal bossing 12 | 157
Hypertension 12 | 396
Joint hyperflexibility 12 | 78
Melanoma 12 | 711
Neurodegenerative disease 12 | 414
Noonan syndrome 12 | 34
Pectus excavatum 12 | 100
Stomach Neoplasms 12 | 300
Strabismus 12 | 270
acute quadriplegic myopathy 12 | 1,158
colon cancer 12 | 1,478
Arthritis 11 | 290
Asthma 11 | 385
adrenocortical carcinoma 11 | 1,428
nasopharyngeal carcinoma 11 | 1,058
spina bifida 11 | 1,074

Tissue

Blood and immune system 118 | 16,909
Digestive Tract 118 | 17,369
Endocrine System 118 | 18,159
Female tissues 118 | 17,400
Male tissues 118 | 17,142
Skin and soft tissues 118 | 17,230
Liver and Pancreas 117 | 16,750
Nervous System 117 | 16,725
Respiratory system 117 | 16,393
Urinary Tract 116 | 16,678
Cardiovascular System 115 | 15,192

Target Family

Kinase 51 | 634
Non-IDG 43 | 12,091
Enzyme 16 | 4,145
Transcription Factor 8 | 1,400
TF/Epigenetic 1 | 38

KEGG Pathway

Neurotrophin signaling pathway 119 | 119
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
Melanoma-associated antigen D1 MAGED1 Tbio Non-IDG -1.55131 46.3 245
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Rho GDP-dissociation inhibitor 3 ARHGDIG Tbio Non-IDG -0.82623 8.55 107
Megakaryocyte-associated tyrosine-protein kinase MATK Tbio Kinase -2.98596 792.3 265
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344