Development Level

Tbio 102 | 11,651
Tchem 50 | 1,388
Tclin 11 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to t... 6 | 278
abnormal embryo size 4 | 220
enlarged heart 4 | 210
small superior vagus ganglion 4 | 74
abnormal bone structure 3 | 187
abnormal gait 3 | 69
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased bone mineral content 3 | 151
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
hypoactivity 3 | 132
increased bone mineral content 3 | 108
increased lean body mass 3 | 172
prenatal lethality prior to he... 3 | 87
decreased circulating amylase ... 2 | 28
decreased circulating insulin ... 2 | 76
decreased heart left ventricle... 2 | 28
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
enlarged uterus 2 | 11
impaired righting response 2 | 26
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
male infertility 2 | 123
persistence of hyaloid vascula... 2 | 33
preweaning lethality, incomple... 2 | 499
abnormal brain morphology 1 | 13
abnormal cecum morphology 1 | 7
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal gallbladder morpholog... 1 | 1
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pancreas morphology 1 | 13
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal vitreous body morphol... 1 | 10
abnormal vocalization 1 | 21
absent testes 1 | 6
absent vibrissae 1 | 12
aorta dilation 1 | 3
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased cardiac stroke volum... 1 | 6
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased thermal nociceptive ... 1 | 2
enlarged cecum 1 | 5
enlarged gallbladder 1 | 2
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hydroencephaly 1 | 14
hydrometra 1 | 53
hyperactivity 1 | 148
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
increased urine microalbumin l... 1 | 2
pale yolk sac 1 | 25
prolonged QT interval 1 | 38
shortened QT interval 1 | 4
small epididymis 1 | 3
stereotypic behavior 1 | 3
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

Carcinoma 108 | 11,493
ovarian cancer 89 | 8,520
psoriasis 84 | 6,694
osteosarcoma 80 | 7,950
Cancer 70 | 2,499
glioblastoma 67 | 5,792
lung cancer 65 | 4,740
medulloblastoma, large-cell 52 | 6,241
lung carcinoma 51 | 2,843
tuberculosis 46 | 2,010
malignant mesothelioma 45 | 3,232
atypical teratoid / rhabdoid tumor 43 | 5,112
pancreatic cancer 43 | 2,398
Astrocytoma, Pilocytic 42 | 3,081
adult high grade glioma 42 | 3,801
ependymoma 41 | 4,679
subependymal giant cell astrocytoma 39 | 2,287
cystic fibrosis 38 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
Breast cancer 36 | 3,578
lung adenocarcinoma 34 | 2,716
non-small cell lung cancer 34 | 2,890
invasive ductal carcinoma 33 | 2,951
juvenile dermatomyositis 31 | 1,187
interstitial cystitis 30 | 2,312
Arthritis 29 | 290
cutaneous lupus erythematosus 29 | 1,057
ulcerative colitis 29 | 1,819
Multiple Sclerosis 28 | 540
diabetes mellitus 28 | 1,728
Kidney cancer 27 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
pituitary cancer 25 | 1,972
Rheumatoid arthritis 24 | 1,191
group 3 medulloblastoma 24 | 4,104
group 4 medulloblastoma 24 | 1,855
Liver Cirrhosis, Experimental 22 | 769
Multiple myeloma 22 | 1,332
Vascular disease 22 | 319
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Asthma 21 | 385
Influenza 21 | 142
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
Inflammatory bowel disease 20 | 151
Pick disease 20 | 1,894
Kidney disease 19 | 430
Schizophrenia 19 | 1,160
oligodendroglioma 19 | 2,850
Bipolar Disorder 18 | 666
Hypertension 18 | 396
Neurodegenerative disease 18 | 414
Obesity 18 | 678
active Crohn's disease 18 | 922
hepatocellular carcinoma 18 | 547
pancreatic carcinoma 18 | 562
primary Sjogren syndrome 18 | 735
primitive neuroectodermal tumor 18 | 3,035
Autosomal recessive predisposition 17 | 1,442
Lung disease 17 | 142
Reperfusion Injury 17 | 86
acute quadriplegic myopathy 17 | 1,158
sarcoidosis 17 | 370
Hypersensitivity reaction type II disease 16 | 253
astrocytic glioma 16 | 2,597
breast carcinoma 16 | 1,638
dermatomyositis 16 | 966
gastric cancer 16 | 459
Alzheimer's disease 15 | 658
Breast Neoplasms 15 | 445
Dermatitis 15 | 157
Mammary Neoplasms 15 | 425
active ulcerative colitis 15 | 764
acute myeloid leukemia 15 | 783
astrocytoma 15 | 1,146
colon cancer 15 | 1,478
esophageal adenocarcinoma 15 | 737
Atherosclerosis 14 | 291
Heart disease 14 | 306
Pneumonia 14 | 174
Waldenstrons macroglobulinemia 14 | 765
Atopic dermatitis 13 | 952
Crohn's disease 13 | 321
Depressive disorder 13 | 409
Hypertensive disease 13 | 292
Melanoma 13 | 711
Neoplasm Invasiveness 13 | 161
Stomach Neoplasms 13 | 300
gastric carcinoma 13 | 807
Brain Ischemia 12 | 110
Cholestasis, Extrahepatic 12 | 25
Coronary artery disease 12 | 268
Fever 12 | 138
Inflammation 12 | 120
Lung Neoplasms 12 | 232
Meningitis 12 | 67
Prostatic Neoplasms 12 | 495
adrenocortical carcinoma 12 | 1,428
spina bifida 12 | 1,074
Arthritis, Rheumatoid 11 | 174
primary pancreatic ductal adenocarcinoma 11 | 1,109

Tissue

Blood and immune system 151 | 16,909
Digestive Tract 150 | 17,369
Endocrine System 150 | 18,159
Urinary Tract 150 | 16,678
Male tissues 149 | 17,142
Female tissues 148 | 17,400
Liver and Pancreas 148 | 16,750
Skin and soft tissues 148 | 17,230
Nervous System 147 | 16,725
Respiratory system 147 | 16,393
Cardiovascular System 142 | 15,192

Target Family

Non-IDG 92 | 12,091
Enzyme 28 | 4,145
Kinase 25 | 634
Ion Channel 10 | 344
Transcription Factor 8 | 1,400
GPCR 2 | 408
Epigenetic 1 | 242

KEGG Pathway

NOD-like receptor signaling pa... 166 | 166
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Inactive caspase-12 CASP12 Tbio Enzyme -2.64252 415.1 429
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
Stimulator of interferon genes protein TMEM173 Tbio Non-IDG -2.37722 230.3 450
Thioredoxin, mitochondrial TXN2 Tbio Non-IDG -2.05954 125.2 260
NLR family member X1 NLRX1 Tbio Non-IDG -1.92925 86.9 143