Development Level

Tbio 35 | 11,445
Tchem 7 | 1,598
Tdark 7 | 6,588

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 6 | 239
abnormal embryo size 3 | 220
abnormal esophagus morphology 2 | 5
abnormal neural tube closure 2 | 46
bleb 2 | 2
decreased bone mineral density 2 | 126
decreased fasted circulating g... 2 | 65
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo development 1 | 7
abnormal forebrain development 1 | 20
abnormal forebrain morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
absent adrenal gland 1 | 2
absent lymph nodes 1 | 3
anophthalmia 1 | 33
convulsive seizures 1 | 13
decreased bone mineral content 1 | 151
decreased circulating calcium ... 1 | 36
decreased circulating glycerol... 1 | 16
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased total body fat amoun... 1 | 134
long tibia 1 | 25
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
small spleen 1 | 19

Disease

Carcinoma 35 | 11,493
ovarian cancer 34 | 8,520
glioblastoma 23 | 5,792
Congenital disorder of glycosylation 22 | 54
osteosarcoma 22 | 7,950
lung cancer 18 | 4,740
atypical teratoid / rhabdoid tumor 16 | 5,112
medulloblastoma, large-cell 15 | 6,241
Autosomal recessive predisposition 14 | 1,442
psoriasis 14 | 6,694
ependymoma 12 | 4,679
group 3 medulloblastoma 12 | 4,104
Epilepsy 11 | 792
Astrocytoma, Pilocytic 10 | 3,081
Multiple myeloma 10 | 1,332
Seizures 10 | 596
lung adenocarcinoma 10 | 2,716
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
invasive ductal carcinoma 9 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Breast cancer 8 | 3,578
Muscle hypotonia 8 | 571
adult high grade glioma 8 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
oligodendroglioma 8 | 2,850
Failure to gain weight 7 | 365
Kidney cancer 7 | 2,613
Pediatric failure to thrive 7 | 365
astrocytoma 7 | 1,146
cystic fibrosis 7 | 1,696
primitive neuroectodermal tumor 7 | 3,035
Isoelectric focusing of serum transferrin consistent with CDG type I 6 | 10
group 4 medulloblastoma 6 | 1,855
non primary Sjogren syndrome sicca 6 | 891
pancreatic cancer 6 | 2,398
pediatric high grade glioma 6 | 1,064
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Small head 5 | 374
Strabismus 5 | 270
juvenile dermatomyositis 5 | 1,187
lung carcinoma 5 | 2,843
ulcerative colitis 5 | 1,819
Creatine phosphokinase serum increased 4 | 110
Elevated creatine kinase 4 | 110
Intellectual disability 4 | 1,016
Optic Atrophy 4 | 242
Pick disease 4 | 1,894
Prenatal onset 4 | 139
acute myeloid leukemia 4 | 783
diabetes mellitus 4 | 1,728
posterior fossa group A ependymoma 4 | 468
Antithrombin III deficiency 3 | 14
Attention deficit hyperactivity disorder 3 | 278
Byzanthine arch palate 3 | 194
Cancer 3 | 2,499
Cerebral atrophy 3 | 178
Congenital muscular dystrophy 3 | 29
Congenital myasthenic syndrome 3 | 25
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Fukuyama congenital muscular dystrophy 3 | 8
Hepatomegaly 3 | 285
Hypoplastic mandible condyle 3 | 275
Liver Dysfunction 3 | 99
Low intelligence 3 | 645
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Muscular dystrophy 3 | 75
Myasthenic Syndromes, Congenital 3 | 16
Poor school performance 3 | 645
Postnatal microcephaly 3 | 24
Schizophrenia 3 | 1,160
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
interstitial cystitis 3 | 2,312
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
primary Sjogren syndrome 3 | 735
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Broad flat nasal bridge 2 | 236
Concave bridge of nose 2 | 195
Curvature of spine 2 | 282
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Nasal bridge wide 2 | 236
Smooth philtrum 2 | 43
progressive supranuclear palsy 2 | 676

Tissue

Endocrine System 49 | 18,159
Female tissues 49 | 17,400
Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Nervous System 48 | 16,725
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Cardiovascular System 47 | 15,192

Target Family

Enzyme 47 | 4,145
Non-IDG 2 | 12,091

KEGG Pathway

N-Glycan biosynthesis 49 | 49
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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