Development Level

Tbio 19 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
male infertility 2 | 123
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87
small testis 1 | 58

Disease

ovarian cancer 17 | 8,520
Carcinoma 14 | 11,493
group 3 medulloblastoma 14 | 4,104
glioblastoma 11 | 5,792
lung cancer 11 | 4,740
malignant mesothelioma 11 | 3,232
Cancer 9 | 2,499
non-small cell lung cancer 9 | 2,890
psoriasis 9 | 6,694
Lynch syndrome 8 | 35
atypical teratoid / rhabdoid tumor 8 | 5,112
medulloblastoma, large-cell 8 | 6,241
osteosarcoma 8 | 7,950
primitive neuroectodermal tumor 8 | 3,035
ependymoma 7 | 4,679
Abdominal Pain 6 | 98
Anxiety 6 | 136
Anxiety disease 6 | 113
Attention deficit hyperactivity disorder 6 | 278
Breast cancer 6 | 3,578
Colorectal Neoplasms 6 | 243
Constipation 6 | 181
Depressive disorder 6 | 409
Dyschezia 6 | 135
Kidney cancer 6 | 2,613
Muscle hypotonia 6 | 571
Nausea and vomiting 6 | 97
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung adenocarcinoma 6 | 2,716
nasopharyngeal carcinoma 6 | 1,058
Autosomal recessive predisposition 5 | 1,442
Colorectal Neoplasms, Hereditary Nonpolyposis 5 | 9
Death in early adulthood 5 | 24
Death in early childhood 5 | 82
Death in infancy 5 | 82
Epilepsy 5 | 792
Familial adenomatous polyposis 5 | 32
Fatigue 5 | 182
Gastrointestinal Hemorrhage 5 | 52
Hereditary Nonpolyposis Colorectal Cancer 5 | 11
Hereditary Nonpolyposis Colorectal Neoplasms 5 | 8
Intermittent migraine headaches 5 | 68
Intracranial hypertension 5 | 32
Irritation - emotion 5 | 68
Malabsorption 5 | 82
Malignant tumor of colon 5 | 19
Migraine Disorders 5 | 76
Muscle Hypertonia 5 | 88
Rectal Neoplasms 5 | 18
Seizures 5 | 596
Waldenstrons macroglobulinemia 5 | 765
Weight decreased 5 | 103
adult high grade glioma 5 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Abnormality of the abdomen 4 | 14
Adenoma 4 | 167
Axillary freckling 4 | 5
Basal cell carcinoma 4 | 54
Basal cell nevi 4 | 23
Birthmark 4 | 35
Cafe-au-Lait Spots 4 | 37
Endometrial Neoplasms 4 | 55
Hematologic Neoplasms 4 | 22
Hyperpigmented macules 4 | 42
Leukemia 4 | 104
Lymphoma 4 | 81
Neuroblastoma 4 | 80
Rhabdomyosarcoma 4 | 39
Sebaceous adenoma 4 | 26
Turcot syndrome 4 | 5
Turcot syndrome (disorder) 4 | 5
Xeroderma pigmentosum 4 | 43
breast carcinoma 4 | 1,638
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
medulloblastoma 4 | 720
Adenocarcinoma of lung 3 | 142
Colon diverticulum anatomic structure 3 | 15
Colonic Neoplasms 3 | 142
Colorectal cancer 3 | 25
Diverticular disease of colon 3 | 15
Endometrial cancer 3 | 311
Endometrial carcinoma 3 | 15
Fibrous skin tumor of tuberous sclerosis 3 | 18
Hereditary nonpolyposis colorectal carcinoma 3 | 18
Increased gastric cancer 3 | 21
Lynch Syndrome 1 3 | 4
Muir-Torre syndrome 3 | 4
Stomach Neoplasms 3 | 300
Torre-Muir syndrome 3 | 3
adrenocortical carcinoma 3 | 1,428
ductal carcinoma in situ 3 | 1,745
invasive ductal carcinoma 3 | 2,951
oligodendroglioma 3 | 2,850
ovarian neoplasm 3 | 99
pituitary cancer 3 | 1,972
astrocytoma 2 | 1,146
juvenile dermatomyositis 2 | 1,187
pancreatic cancer 2 | 2,398

Tissue

Blood and immune system 23 | 16,909
Cardiovascular System 23 | 15,192
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678

Target Family

Non-IDG 15 | 12,091
Enzyme 7 | 4,145
Epigenetic 1 | 242

KEGG Pathway

Mismatch repair 23 | 23
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.30866 19.7 176
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Exonuclease 1 EXO1 Tbio Enzyme -2.64302 437.0 263
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.95222 8.52 115
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
DNA mismatch repair protein Mlh1 MLH1 Tbio Non-IDG -3.34283 2352.6 495