Development Level

Tbio 822 | 11,445
Tchem 247 | 1,598
Tclin 109 | 613
Tdark 85 | 6,588

Collection

Kinase: IDG Consortium (Target... 6 | 125
RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 127 | 979
embryonic lethality prior to o... 48 | 239
embryonic lethality prior to t... 39 | 278
abnormal behavior 29 | 298
preweaning lethality, incomple... 28 | 499
abnormal embryo size 25 | 220
decreased total body fat amoun... 20 | 207
increased bone mineral content 18 | 108
increased lean body mass 17 | 172
decreased bone mineral content 16 | 151
abnormal bone structure 14 | 187
enlarged heart 14 | 210
hypoactivity 14 | 132
decreased bone mineral density 13 | 126
embryonic growth retardation 13 | 106
abnormal heart morphology 12 | 162
cataract 12 | 92
decreased body weight 11 | 161
decreased circulating glucose ... 11 | 126
increased total body fat amoun... 11 | 134
abnormal lens morphology 10 | 81
decreased body length 10 | 101
decreased lean body mass 10 | 135
decreased vertical activity 10 | 208
increased circulating alkaline... 10 | 122
male infertility 10 | 123
abnormal seminal vesicle morph... 9 | 114
abnormal neural tube closure 8 | 46
decreased circulating HDL chol... 8 | 68
decreased circulating alkaline... 8 | 46
decreased erythrocyte cell num... 8 | 62
decreased grip strength 8 | 116
hyperactivity 8 | 148
increased bone mineral density 8 | 72
increased circulating sodium l... 8 | 71
abnormal bone mineralization 7 | 38
decreased circulating choleste... 7 | 93
decreased circulating serum al... 7 | 82
decreased hemoglobin content 7 | 68
decreased mean corpuscular vol... 7 | 79
enlarged lymph nodes 7 | 37
increased circulating potassiu... 7 | 29
increased or absent threshold ... 7 | 101
prenatal lethality prior to he... 7 | 87
decreased prepulse inhibition 6 | 82
improved glucose tolerance 6 | 79
increased monocyte cell number 6 | 63
increased startle reflex 6 | 112
microphthalmia 6 | 26
persistence of hyaloid vascula... 6 | 33
short tibia 6 | 97
abnormal eye morphology 5 | 68
abnormal gait 5 | 69
abnormal kidney morphology 5 | 65
abnormal skin morphology 5 | 50
abnormal vocalization 5 | 21
decreased circulating phosphat... 5 | 27
decreased fasted circulating g... 5 | 65
edema 5 | 59
hydrometra 5 | 53
impaired glucose tolerance 5 | 75
increased circulating HDL chol... 5 | 80
increased circulating choleste... 5 | 66
increased fasted circulating g... 5 | 76
increased grip strength 5 | 41
increased heart weight 5 | 62
increased mean corpuscular vol... 5 | 92
pallor 5 | 34
thrombocytopenia 5 | 56
abnormal coat-hair pigmentatio... 4 | 64
abnormal midbrain development 4 | 20
abnormal neural tube morpholog... 4 | 12
abnormal retina morphology 4 | 71
abnormal retinal vasculature m... 4 | 27
anophthalmia 4 | 33
brachydactyly 4 | 19
decreased caudal vertebrae num... 4 | 53
decreased circulating alanine ... 4 | 47
decreased circulating bilirubi... 4 | 19
decreased circulating calcium ... 4 | 36
decreased circulating insulin ... 4 | 76
decreased circulating iron lev... 4 | 32
decreased circulating triglyce... 4 | 79
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
decreased startle reflex 4 | 75
increased blood urea nitrogen ... 4 | 48
increased circulating bilirubi... 4 | 16
increased circulating phosphat... 4 | 26
increased mean corpuscular hem... 4 | 96
increased mean platelet volume 4 | 45
long tibia 4 | 25
pale yolk sac 4 | 25
small kidney 4 | 16
small superior vagus ganglion 4 | 74
syndactyly 4 | 23
abnormal locomotor behavior 3 | 24
abnormal placenta size 3 | 20
abnormal skin coloration 3 | 25
decreased circulating creatini... 3 | 39

Disease

Carcinoma 792 | 11,493
ovarian cancer 637 | 8,520
osteosarcoma 503 | 7,950
psoriasis 499 | 6,694
medulloblastoma, large-cell 399 | 6,241
lung cancer 385 | 4,740
glioblastoma 356 | 5,792
Autosomal recessive predisposition 312 | 1,442
atypical teratoid / rhabdoid tumor 308 | 5,112
ependymoma 294 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 285 | 1,962
intraductal papillary-mucinous neoplasm (IPMN) 256 | 3,291
group 3 medulloblastoma 254 | 4,104
malignant mesothelioma 247 | 3,232
Breast cancer 224 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 219 | 2,955
non-small cell lung cancer 216 | 2,890
adult high grade glioma 213 | 3,801
invasive ductal carcinoma 212 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 205 | 2,989
lung adenocarcinoma 201 | 2,716
Astrocytoma, Pilocytic 192 | 3,081
lung carcinoma 187 | 2,843
Epilepsy 182 | 792
primitive neuroectodermal tumor 180 | 3,035
oligodendroglioma 176 | 2,850
pancreatic cancer 176 | 2,398
Cancer 174 | 2,499
Multiple myeloma 173 | 1,332
tuberculosis 172 | 2,010
Seizures 167 | 596
astrocytic glioma 165 | 2,597
Intellectual disability 159 | 1,016
interstitial cystitis 159 | 2,312
Cognitive delay 149 | 608
Global developmental delay 149 | 608
Mental and motor retardation 149 | 608
Muscle hypotonia 146 | 571
subependymal giant cell astrocytoma 145 | 2,287
ulcerative colitis 144 | 1,819
ductal carcinoma in situ 143 | 1,745
pituitary cancer 134 | 1,972
Pick disease 131 | 1,894
diabetes mellitus 128 | 1,728
Dull intelligence 127 | 645
Low intelligence 127 | 645
Mental Retardation 127 | 645
Mental deficiency 127 | 645
Poor school performance 127 | 645
Kidney cancer 126 | 2,613
group 4 medulloblastoma 120 | 1,855
Schizophrenia 119 | 1,160
colon cancer 116 | 1,478
cystic fibrosis 114 | 1,696
breast carcinoma 112 | 1,638
adrenocortical carcinoma 107 | 1,428
Failure to gain weight 104 | 365
Pediatric failure to thrive 104 | 365
astrocytoma 101 | 1,146
Liver Cirrhosis, Experimental 96 | 769
active Crohn's disease 93 | 922
Cerebellar Ataxia 87 | 304
Waldenstrons macroglobulinemia 86 | 765
esophageal adenocarcinoma 75 | 737
non primary Sjogren syndrome sicca 75 | 891
nasopharyngeal carcinoma 74 | 1,058
Obesity 73 | 678
Bipolar Disorder 72 | 666
pediatric high grade glioma 69 | 1,064
Atopic dermatitis 68 | 952
Short stature 68 | 531
active ulcerative colitis 67 | 764
acute quadriplegic myopathy 67 | 1,158
Hepatomegaly 66 | 285
cutaneous lupus erythematosus 66 | 1,057
primary pancreatic ductal adenocarcinoma 66 | 1,109
Prostatic Neoplasms 64 | 495
Nystagmus 62 | 317
dermatomyositis 62 | 966
gastric carcinoma 62 | 807
spina bifida 62 | 1,074
aldosterone-producing adenoma 61 | 665
Infantile onset 59 | 238
Optic Atrophy 59 | 242
Dystonia 58 | 164
Rheumatoid arthritis 58 | 1,191
Acidosis, Lactic 57 | 97
Vomiting 57 | 116
Lactic acidemia 56 | 95
Depressive disorder 55 | 409
Hyperreflexia 55 | 209
nephrosclerosis 55 | 333
Highly variable clinical phenotype 54 | 150
Highly variable phenotype and severity 54 | 150
Highly variable phenotype, even within families 54 | 150
Phenotypic variability 54 | 150
juvenile dermatomyositis 54 | 1,187
Sensorineural Hearing Loss (disorder) 53 | 284
Small head 53 | 374
acute myeloid leukemia 53 | 783

Tissue

Endocrine System 1,236 | 18,159
Digestive Tract 1,233 | 17,369
Female tissues 1,222 | 17,400
Skin and soft tissues 1,217 | 17,230
Liver and Pancreas 1,216 | 16,750
Urinary Tract 1,210 | 16,678
Blood and immune system 1,204 | 16,909
Male tissues 1,202 | 17,142
Nervous System 1,184 | 16,725
Respiratory system 1,164 | 16,393
Cardiovascular System 1,104 | 15,192

Target Family

Enzyme 1,099 | 4,145
Kinase 91 | 634
Non-IDG 64 | 12,091
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
Transporter 2 | 473

KEGG Pathway

Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hexosaminidase D HEXDC Tbio Enzyme -0.60206 3.83 63
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
Chondroitin sulfate synthase 1 CHSY1 Tbio Enzyme -1.69082 48.5 101
Cytochrome c oxidase assembly protein COX15 homolog COX15 Tbio Enzyme -1.37513 23.0 104
Cysteine sulfinic acid decarboxylase CSAD Tbio Enzyme -2.16604 143.8 134
Nicotinamide N-methyltransferase NNMT Tchem Enzyme -2.09313 121.9 268
Retinal dehydrogenase 2 ALDH1A2 Tbio Enzyme -2.25078 175.3 229