Development Level

Tbio 769 | 10,625
Tchem 273 | 1,890
Tclin 107 | 602
Tdark 105 | 7,003

Collection

Kinase: IDG Consortium (Targets) 6 | 125
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 84 | 633
embryonic lethality prior to o... 37 | 148
embryonic lethality prior to t... 32 | 187
abnormal behavior 24 | 226
decreased lean body mass 18 | 195
decreased total body fat amoun... 18 | 186
decreased bone mineral content 15 | 157
abnormal embryo size 14 | 112
decreased body weight 14 | 174
hypoactivity 13 | 89
preweaning lethality, incomple... 13 | 260
abnormal lens morphology 12 | 73
decreased circulating glucose ... 11 | 121
increased bone mineral content 11 | 92
decreased bone mineral density 10 | 126
decreased circulating HDL chol... 10 | 77
increased circulating sodium l... 9 | 71
increased fasted circulating g... 9 | 68
increased grip strength 9 | 83
increased lean body mass 9 | 107
abnormal bone structure 8 | 131
abnormal retina morphology 8 | 100
prenatal lethality prior to he... 8 | 64
decreased circulating alkaline... 7 | 41
decreased circulating choleste... 7 | 85
decreased circulating serum al... 7 | 79
decreased circulating triglyce... 7 | 83
enlarged lymph nodes 7 | 27
increased circulating alkaline... 7 | 119
male infertility 7 | 62
abnormal bone mineralization 6 | 55
decreased body length 6 | 108
decreased circulating insulin ... 6 | 75
decreased prepulse inhibition 6 | 52
enlarged heart 6 | 111
hyperactivity 6 | 108
increased exploration in new e... 6 | 56
increased total body fat amoun... 6 | 57
short tibia 6 | 82
abnormal neural tube closure 5 | 37
abnormal seminal vesicle morph... 5 | 47
decreased Ly6C low monocyte nu... 5 | 23
decreased NK T cell number 5 | 28
decreased eosinophil cell numb... 5 | 41
decreased erythrocyte cell num... 5 | 43
decreased grip strength 5 | 123
decreased hemoglobin content 5 | 53
decreased mean corpuscular vol... 5 | 50
decreased mean platelet volume 5 | 12
decreased startle reflex 5 | 48
increased mean corpuscular hem... 5 | 93
increased mean platelet volume 5 | 19
thrombocytopenia 5 | 46
abnormal hindbrain development 4 | 24
abnormal kidney morphology 4 | 30
abnormal midbrain development 4 | 22
abnormal retinal pigmentation 4 | 61
abnormal vocalization 4 | 21
decreased CD8-positive, alpha-... 4 | 26
decreased T cell number 4 | 31
decreased circulating alanine ... 4 | 53
decreased circulating calcium ... 4 | 33
decreased effector memory CD8-... 4 | 24
decreased fasted circulating g... 4 | 49
decreased leukocyte cell numbe... 4 | 54
embryonic growth retardation 4 | 28
impaired glucose tolerance 4 | 52
improved glucose tolerance 4 | 56
increased body weight 4 | 42
increased bone mineral density 4 | 52
increased circulating chloride... 4 | 43
increased circulating choleste... 4 | 53
increased circulating potassiu... 4 | 31
increased or absent threshold ... 4 | 128
increased red blood cell distr... 4 | 21
abnormal behavioral response t... 3 | 52
abnormal coat-hair pigmentatio... 3 | 54
abnormal skin coloration 3 | 18
abnormal skin morphology 3 | 23
abnormal sleep behavior 3 | 63
abnormal spleen morphology 3 | 36
abnormal tail movements 3 | 12
cardiovascular system phenotyp... 3 | 35
decreased caudal vertebrae num... 3 | 49
decreased circulating total pr... 3 | 41
decreased heart weight 3 | 44
decreased lactate dehydrogenas... 3 | 14
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
decreased neutrophil cell numb... 3 | 37
female infertility 3 | 34
increased CD4-positive, CD25-p... 3 | 18
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating bilirubi... 3 | 16
increased circulating free fat... 3 | 17
increased mean corpuscular vol... 3 | 91
increased rib number 3 | 41
persistence of hyaloid vascula... 3 | 22
thrombocytosis 3 | 23

Disease

ovarian cancer 635 | 8,491
osteosarcoma 503 | 7,933
psoriasis 495 | 6,685
medulloblastoma, large-cell 399 | 6,234
lung cancer 374 | 4,473
glioblastoma 346 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 270 | 1,795
atypical teratoid / rhabdoid tumor 259 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 257 | 3,289
malignant mesothelioma 243 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 219 | 2,956
invasive ductal carcinoma 212 | 2,950
non-small cell lung cancer 208 | 2,798
Breast cancer 206 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 206 | 2,988
lung adenocarcinoma 203 | 2,714
pilocytic astrocytoma 189 | 3,086
lung carcinoma 185 | 2,844
primitive neuroectodermal tumor 178 | 3,031
pancreatic cancer 177 | 2,300
oligodendroglioma 175 | 2,849
ulcerative colitis 173 | 2,087
Multiple myeloma 172 | 1,327
Cancer 160 | 2,346
interstitial cystitis 158 | 2,299
ependymoma 154 | 2,514
pediatric high grade glioma 152 | 2,712
ductal carcinoma in situ 144 | 1,745
astrocytic glioma 143 | 2,241
subependymal giant cell astrocytoma 142 | 2,287
group 3 medulloblastoma 141 | 2,254
pituitary cancer 134 | 1,972
Pick disease 131 | 1,893
tuberculosis 131 | 1,563
adult high grade glioma 127 | 2,148
group 4 medulloblastoma 127 | 1,875
astrocytoma 122 | 1,493
colon cancer 117 | 1,475
diabetes mellitus 115 | 1,663
cystic fibrosis 111 | 1,670
adrenocortical carcinoma 110 | 1,427
breast carcinoma 110 | 1,614
posterior fossa group A ependymoma 99 | 1,511
medulloblastoma 96 | 1,524
posterior fossa group B ependymoma 91 | 1,530
active Crohn's disease 90 | 918
Waldenstrons macroglobulinemia 85 | 764
primary pancreatic ductal adenocarcinoma 82 | 1,271
atypical teratoid/rhabdoid tumor 81 | 1,095
sonic hedgehog group medulloblastoma 78 | 1,482
esophageal adenocarcinoma 75 | 737
nasopharyngeal carcinoma 74 | 1,056
Obesity 72 | 616
non primary Sjogren syndrome sicca 71 | 840
Atopic dermatitis 69 | 944
Carcinoma 69 | 2,147
cutaneous lupus erythematosus 67 | 1,056
acute quadriplegic myopathy 66 | 1,157
Prostatic Neoplasms 63 | 471
gastric carcinoma 63 | 832
dermatomyositis 62 | 966
Intellectual disability 61 | 573
spina bifida 60 | 1,064
aldosterone-producing adenoma 59 | 664
Rheumatoid Arthritis 56 | 1,170
nephrosclerosis 55 | 329
juvenile dermatomyositis 54 | 1,189
Schizophrenia 52 | 503
acute myeloid leukemia 52 | 785
Diabetes mellitus type 2 51 | 69
fibroadenoma 51 | 557
Leigh disease 48 | 81
Down syndrome 46 | 548
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
hepatocellular carcinoma 44 | 550
Alzheimer's disease 43 | 644
primary Sjogren syndrome 42 | 788
tuberculosis and treatment for 6 months 42 | 686
pancreatic carcinoma 41 | 567
Liver carcinoma 40 | 217
IGA Glomerulonephritis 39 | 454
chronic rhinosinusitis 36 | 512
Epilepsy 35 | 346
Mammary Neoplasms 35 | 410
Neurodegenerative disease 35 | 383
active ulcerative colitis 35 | 477
progressive supranuclear palsy 35 | 674
Hypertension 34 | 293
Polycystic Ovary Syndrome 34 | 334
Stomach Neoplasms 34 | 282
non-small cell lung carcinoma 34 | 413
Endometriosis 33 | 535
Parkinson's disease 33 | 364
Anemia 31 | 252
Atherosclerosis 30 | 275
Coronary artery disease 30 | 240
mucosa-associated lymphoid tissue lymphoma 30 | 480
tuberculosis and treatment for 3 months 30 | 327
Duchenne muscular dystrophy 29 | 602
inflammatory breast cancer 28 | 404

Tissue

Digestive Tract 1,248 | 18,472
Liver and Pancreas 1,243 | 18,135
Urinary Tract 1,243 | 18,443
Nervous System 1,241 | 18,560
Female tissues 1,239 | 18,646
Endocrine System 1,238 | 18,511
Blood and immune system 1,235 | 17,994
Skin and soft tissues 1,232 | 18,114
Cardiovascular System 1,229 | 17,957
Male tissues 1,224 | 17,968
Respiratory system 1,209 | 17,483

Target Family

Enzyme 1,092 | 4,146
Kinase 91 | 634
Non-IDG 62 | 11,969
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
Transporter 2 | 473

KEGG Pathway

Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.7 122
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.55417 348.6 173
4-hydroxy-2-oxoglutarate aldolase, mitochondrial HOGA1 Tchem Enzyme -1.32920 1.73 5
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.84683 72.3 120
Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1 Tbio Enzyme -1.71423 54.0 77
Hydroxyacid oxidase 1 HAO1 Tchem Enzyme -2.99254 984.0 189