Development Level

Tbio 769 | 10,625
Tchem 273 | 1,890
Tclin 107 | 602
Tdark 105 | 7,003

Collection

Eligible Kinase Proteins 15 | 134

IMPC Term

preweaning lethality, complete... 84 | 633
embryonic lethality prior to o... 37 | 148
embryonic lethality prior to t... 32 | 187
abnormal behavior 24 | 226
decreased lean body mass 18 | 195
decreased total body fat amoun... 18 | 186
decreased bone mineral content 15 | 157
abnormal embryo size 14 | 112
decreased body weight 14 | 174
hypoactivity 13 | 89
preweaning lethality, incomple... 13 | 260
abnormal lens morphology 12 | 73
decreased circulating glucose ... 11 | 121
increased bone mineral content 11 | 92
decreased bone mineral density 10 | 126
decreased circulating HDL chol... 10 | 77
increased circulating sodium l... 9 | 71
increased fasted circulating g... 9 | 68
increased grip strength 9 | 83
increased lean body mass 9 | 107
abnormal bone structure 8 | 131
abnormal retina morphology 8 | 100
prenatal lethality prior to he... 8 | 64
decreased circulating alkaline... 7 | 41
decreased circulating choleste... 7 | 85
decreased circulating serum al... 7 | 79
decreased circulating triglyce... 7 | 83
enlarged lymph nodes 7 | 27
increased circulating alkaline... 7 | 119
male infertility 7 | 62
abnormal bone mineralization 6 | 55
decreased body length 6 | 108
decreased circulating insulin ... 6 | 75
decreased prepulse inhibition 6 | 52
enlarged heart 6 | 111
hyperactivity 6 | 108
increased exploration in new e... 6 | 56
increased total body fat amoun... 6 | 57
short tibia 6 | 82
abnormal neural tube closure 5 | 37
abnormal seminal vesicle morph... 5 | 47
decreased Ly6C low monocyte nu... 5 | 23
decreased NK T cell number 5 | 28
decreased eosinophil cell numb... 5 | 41
decreased erythrocyte cell num... 5 | 43
decreased grip strength 5 | 123
decreased hemoglobin content 5 | 53
decreased mean corpuscular vol... 5 | 50
decreased mean platelet volume 5 | 12
decreased startle reflex 5 | 48
increased mean corpuscular hem... 5 | 93
increased mean platelet volume 5 | 19
thrombocytopenia 5 | 46
abnormal hindbrain development 4 | 24
abnormal kidney morphology 4 | 30
abnormal midbrain development 4 | 22
abnormal retinal pigmentation 4 | 61
abnormal vocalization 4 | 21
decreased CD8-positive, alpha-... 4 | 26
decreased T cell number 4 | 31
decreased circulating alanine ... 4 | 53
decreased circulating calcium ... 4 | 33
decreased effector memory CD8-... 4 | 24
decreased fasted circulating g... 4 | 49
decreased leukocyte cell numbe... 4 | 54
embryonic growth retardation 4 | 28
impaired glucose tolerance 4 | 52
improved glucose tolerance 4 | 56
increased body weight 4 | 42
increased bone mineral density 4 | 52
increased circulating chloride... 4 | 43
increased circulating choleste... 4 | 53
increased circulating potassiu... 4 | 31
increased or absent threshold ... 4 | 128
increased red blood cell distr... 4 | 21
abnormal behavioral response t... 3 | 52
abnormal coat/hair pigmentatio... 3 | 54
abnormal skin coloration 3 | 18
abnormal skin morphology 3 | 23
abnormal sleep behavior 3 | 63
abnormal spleen morphology 3 | 36
abnormal tail movements 3 | 12
cardiovascular system phenotyp... 3 | 35
decreased caudal vertebrae num... 3 | 49
decreased circulating total pr... 3 | 41
decreased heart weight 3 | 44
decreased lactate dehydrogenas... 3 | 14
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
decreased neutrophil cell numb... 3 | 37
female infertility 3 | 34
increased CD4-positive, CD25-p... 3 | 18
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating bilirubi... 3 | 16
increased circulating free fat... 3 | 17
increased mean corpuscular vol... 3 | 91
increased rib number 3 | 41
persistence of hyaloid vascula... 3 | 22
thrombocytosis 3 | 23

Disease

ovarian cancer 634 | 8,484
osteosarcoma 503 | 7,933
psoriasis 495 | 6,685
medulloblastoma, large-cell 399 | 6,234
lung cancer 373 | 4,466
glioblastoma 346 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 270 | 1,795
atypical teratoid / rhabdoid tumor 259 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 257 | 3,289
malignant mesothelioma 243 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 219 | 2,956
invasive ductal carcinoma 212 | 2,950
non-small cell lung cancer 208 | 2,798
Breast cancer 206 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 206 | 2,988
lung adenocarcinoma 203 | 2,713
pilocytic astrocytoma 189 | 3,086
lung carcinoma 185 | 2,844
primitive neuroectodermal tumor 178 | 3,031
pancreatic cancer 177 | 2,300
oligodendroglioma 175 | 2,849
ulcerative colitis 173 | 2,087
Multiple myeloma 172 | 1,327
Cancer 160 | 2,346
interstitial cystitis 158 | 2,299
ependymoma 154 | 2,514
pediatric high grade glioma 152 | 2,712
ductal carcinoma in situ 144 | 1,745
astrocytic glioma 143 | 2,241
subependymal giant cell astrocytoma 142 | 2,287
group 3 medulloblastoma 141 | 2,254
pituitary cancer 134 | 1,972
Pick disease 131 | 1,893
tuberculosis 130 | 1,557
adult high grade glioma 127 | 2,148
group 4 medulloblastoma 127 | 1,875
astrocytoma 122 | 1,493
colon cancer 117 | 1,475
diabetes mellitus 115 | 1,663
adrenocortical carcinoma 110 | 1,427
breast carcinoma 110 | 1,614
cystic fibrosis 110 | 1,665
posterior fossa group A ependymoma 99 | 1,511
medulloblastoma 96 | 1,524
posterior fossa group B ependymoma 91 | 1,530
active Crohn's disease 90 | 918
Waldenstrons macroglobulinemia 85 | 765
primary pancreatic ductal adenocarcinoma 82 | 1,271
atypical teratoid/rhabdoid tumor 81 | 1,095
sonic hedgehog group medulloblastoma 78 | 1,482
esophageal adenocarcinoma 75 | 737
nasopharyngeal carcinoma 74 | 1,056
Obesity 72 | 616
non primary Sjogren syndrome sicca 71 | 840
Atopic dermatitis 69 | 944
Carcinoma 69 | 2,147
cutaneous lupus erythematosus 67 | 1,056
acute quadriplegic myopathy 66 | 1,157
Prostatic Neoplasms 63 | 471
gastric carcinoma 63 | 832
dermatomyositis 62 | 933
Intellectual disability 61 | 573
spina bifida 60 | 1,064
aldosterone-producing adenoma 59 | 664
Rheumatoid Arthritis 56 | 1,160
nephrosclerosis 55 | 329
juvenile dermatomyositis 54 | 1,189
Schizophrenia 52 | 501
acute myeloid leukemia 52 | 780
Diabetes mellitus type 2 51 | 69
fibroadenoma 51 | 557
Leigh disease 48 | 81
Down syndrome 46 | 548
Treatment Refractory Type 2 Diabetes Mellitus 46 | 53
Alzheimer's disease 43 | 644
hepatocellular carcinoma 43 | 532
primary Sjogren syndrome 42 | 789
tuberculosis and treatment for 6 months 42 | 686
pancreatic carcinoma 41 | 567
Liver carcinoma 40 | 217
IGA Glomerulonephritis 39 | 454
chronic rhinosinusitis 36 | 512
Epilepsy 35 | 346
Mammary Neoplasms 35 | 410
Neurodegenerative disease 35 | 383
active ulcerative colitis 35 | 477
progressive supranuclear palsy 35 | 674
Polycystic Ovary Syndrome 34 | 332
Stomach Neoplasms 34 | 282
non-small cell lung carcinoma 34 | 413
Endometriosis 33 | 535
Hypertension 33 | 287
Parkinson's disease 33 | 364
Anemia 31 | 252
Atherosclerosis 30 | 275
Coronary artery disease 30 | 240
mucosa-associated lymphoid tissue lymphoma 30 | 480
tuberculosis and treatment for 3 months 30 | 327
Duchenne muscular dystrophy 29 | 602
inflammatory breast cancer 28 | 404

Tissue

Digestive Tract 1,248 | 18,473
Liver and Pancreas 1,243 | 18,136
Urinary Tract 1,243 | 18,444
Nervous System 1,241 | 18,561
Female tissues 1,239 | 18,647
Endocrine System 1,238 | 18,512
Blood and immune system 1,235 | 17,995
Skin and soft tissues 1,232 | 18,115
Cardiovascular System 1,229 | 17,958
Male tissues 1,224 | 17,969
Respiratory system 1,209 | 17,484

Target Family

Enzyme 1,092 | 4,146
Kinase 91 | 634
Non-IDG 62 | 11,971
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
Transporter 2 | 473

KEGG Pathway

Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Beta-1,4 N-acetylgalactosaminyltransferase 1 B4GALNT1 Tbio Enzyme -1.85387 67.6 146
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A MGAT5 Tchem Enzyme -2.07315 133.7 104
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase MGAT3 Tchem Enzyme -1.22408 15.8 139
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244